Effect of Cell Adhesion Molecules on the Neurite Outgrowth of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons [0.03%]
少突胶质细胞源性神经营养因子诱导多能干细胞分化神经元样细胞的作用及机制研究
Su-Ping Peng,Melitta Schachner,Erik Boddeke et al.
Su-Ping Peng et al.
Intrastriatal transplantation of dopaminergic neurons has been shown to be a potentially very effective therapeutic approach for the treatment of Parkinson's disease (PD). With the detection of induced pluripotent stem cells (iPSCs), an unl...
Involvement of Cyclin-Dependent Kinase 1 during Postovulatory Aging-Mediated Abortive Spontaneous Egg Activation in Rat Eggs Cultured In Vitro [0.03%]
cyclin依赖性激酶1介导的卵母细胞激活失败在体外培养的老化卵泡晚期次级卵母细胞中的作用研究
Shilpa Prasad,Biplob Koch,Shail K Chaube
Shilpa Prasad
Freshly ovulated rat eggs do not remain arrested at metaphase II (MII) and undergo exit from MII arrest with initiation of extrusion of the second polar body (PBII), a characteristic feature of abortive spontaneous egg activation (SEA). The...
Anna Lange-Consiglio,Alessio Romaldini,Alessio Correani et al.
Anna Lange-Consiglio et al.
Recent studies have revealed the presence of a mesenchymal stem cell (MSC) population in human and in gilt granulosa cells (GCs), thus increasing the interest in identifying the same population in the bovine species. We first isolated GCs b...
Methyl-CpG-Binding Protein 2 Improves the Development of Mouse Somatic Cell Nuclear Transfer Embryos [0.03%]
甲基化CpG岛结合蛋白2改善体细胞克隆胚胎发育效果
Zhen-Dong Wang,Lian Duan,Zi-Hui Zhang et al.
Zhen-Dong Wang et al.
Methyl-CpG-binding domain proteins (MBPs) connect DNA methylation and histone modification, which are the key changes of somatic cell reprogramming. Methyl-CpG-binding protein 2 (MeCP2) was the first discovered MBP that has been extensively...
Big Animal Cloning Using Transgenic Induced Pluripotent Stem Cells: A Case Study of Goat Transgenic Induced Pluripotent Stem Cells [0.03%]
大动物转基因诱导多能干细胞的克隆：山羊转基因诱导多能干细胞的案例研究
Hui Song,Hui Li,Mingrui Huang et al.
Hui Song et al.
Using of embryonic stem cells (ESCs) could improve production traits and disease resistance by improving the efficiency of somatic cell nuclear transfer (SCNT) technology. However, robust ESCs have not been established from domestic ungulat...
Comparison of the Ultrastructures of Primed and Naïve Mouse Embryonic Stem Cells [0.03%]
小鼠诱导多能干细胞和胚胎干细胞超微结构的比较研究
Dongmei Lai,Shixia Bu
Dongmei Lai
Culture conditions have been established to maintain the pluripotency of mouse naïve and primed embryonic stem cells (ESCs) using human amnion epithelial cells (hAECs) as the feeder layer. In this study, the ultrastructures of mouse primed...
Comparative Study
Cellular reprogramming. 2016 Feb;18(1):48-53. DOI:10.1089/cell.2015.0063 2016
Hypoxia Enhances Direct Reprogramming of Mouse Fibroblasts to Cardiomyocyte-Like Cells [0.03%]
缺氧增强直接重编程使小鼠成纤维细胞向心肌细胞样细胞
Yanyan Wang,Shujun Shi,Huiwen Liu et al.
Yanyan Wang et al.
Recent work has shown that mouse and human fibroblasts can be reprogrammed to cardiomyocyte-like cells with a combination of transcription factors. Current research has focused on improving the efficiency and mechanisms for fibroblast repro...
Generation of Arbas Cashmere Goat Induced Pluripotent Stem Cells Through Fibroblast Reprogramming [0.03%]
通过成纤维细胞重编程生成阿拉巴斯现金毛羊诱导性多能干细胞
Dapeng Tai,Pengxia Liu,Jing Gao et al.
Dapeng Tai et al.
Various factors affect the process of obtaining stable Arbas cashmere goat embryonic stem cells (ESCs), for example, the difficulty in isolating cells at the appropriate stage of embryonic development, the in vitro culture environment, and ...
Transcriptome Analysis of Pig In Vivo, In Vitro-Fertilized, and Nuclear Transfer Blastocyst-Stage Embryos Treated with Histone Deacetylase Inhibitors Postfusion and Activation Reveals Changes in the Lysosomal Pathway [0.03%]
组蛋白去乙酰化酶抑制剂处理后的猪体内受精、体外受精和核转移囊胚期胚胎的转录组分析揭示了溶酶体途径的变化
Kristin M Whitworth,Jiude Mao,Kiho Lee et al.
Kristin M Whitworth et al.
Genetically modified pigs are commonly created via somatic cell nuclear transfer (SCNT). Treatment of reconstructed embryos with histone deacetylase inhibitors (HDACi) immediately after activation improves cloning efficiency. The objective ...