Alpha-A-Crystallin Protects Lens Epithelial Cell-Derived iPSC-Like Cells Against Apoptosis Induced by Oxidative Stress [0.03%]
阿尔法A-晶体蛋白通过氧化应激诱导的细胞凋亡保护人眼前囊细胞源性类ips细胞
Yixin Yu,Haibo Jiang,Haibo Li et al.
Yixin Yu et al.
Cataract, the leading cause of blindness worldwide, is caused by the apoptosis of lens epithelial cells (LECs). αA-crystallin is a major structural protein of the lens. However, the antiapoptotic function of αA-crystallin in lens stem cel...
Effect of Sex of Embryo on Developmental Competence, Epigenetic Status, and Gene Expression in Buffalo (Bubalus bubalis) Embryos Produced by Hand-Made Cloning [0.03%]
性别对水 buffalo 体细胞克隆胚胎发育、表观遗传重编程及基因表达的影响
Anjit Sandhu,Sushil K Mohapatra,Himanshu Agrawal et al.
Anjit Sandhu et al.
Buffalo embryos were produced by hand-made cloning using skin fibroblasts from male and female buffaloes (n = 4 each) as donor cells for examining the effect of sex. Although the rate of blastocyst formation (43.8% ± 1.31% vs. 42.2% ± 1.2...
Generation of Induced Pluripotent Stem Cells with Substitutes for Yamanaka's Four Transcription Factors [0.03%]
用替代山中伸弥四种转录因子的方法生成诱导多功能干细胞
Xiong Xiao,Nan Li,Dapeng Zhang et al.
Xiong Xiao et al.
Induced pluripotent stem cells (iPSCs) share many characteristics with embryonic stem cells, but lack ethical controversy. They provide vast opportunities for disease modeling, pathogenesis understanding, therapeutic drug development, toxic...
Effect of Long-Term Exposure of Donor Nuclei to the Oocyte Cytoplasm on Production of Cloned Mice Using Serial Nuclear Transfer [0.03%]
受体卵母细胞胞浆长期影响供体核对系列核移植克隆小鼠生产的影响研究
Sayaka Wakayama,Yoshiaki Tanabe,Hiroaki Nagatomo et al.
Sayaka Wakayama et al.
Although animal cloning is becoming increasingly practicable, cloned embryos possess many abnormalities and so there has been a low success rate for producing live animals. This is most likely due to incomplete reprogramming of somatic cell...
Identification of Stable OCT4+NANOG- State in Somatic Cell Reprogramming [0.03%]
体细胞重编程中OCT4+NANOG稳定表达状态的鉴定
Syed Mohammed Musheer Aalam,Kannan Vrindavan Manian,Sumitha Prameela Bharathan et al.
Syed Mohammed Musheer Aalam et al.
Dedifferentiation Effects of Rabbit Regenerating Tissue on Partially Differentiated Cells [0.03%]
兔子再生组织对部分分化细胞的去分化效应
Mahdi Mirahmadi,Saeideh Nakhaei-Rad,Maryam M Matin et al.
Mahdi Mirahmadi et al.
Cell Stemness can be achieved by various reprogramming techniques namely, somatic cell nuclear transfer, cell fusion, cell extracts, and introduction of transcription factors from which induced pluripotent stem cells (iPSCs) are obtained. i...
Long Noncoding RNA ROR Regulates Proliferation, Invasion, and Stemness of Gastric Cancer Stem Cell [0.03%]
长链非编码RNA ROR调节胃癌干细胞的增殖、侵袭和干性
Shuai Wang,Feng Liu,Junji Deng et al.
Shuai Wang et al.
Gastric cancer remains an incurable malignance and the second leading cause of cancer death globally. Recent progress in gastric cancer research has demonstrated the crucial roles of cancer stem cells (CSCs) in the development, metastasis, ...
Activation-Induced Cytidine Deaminase Induces DNA Demethylation of Pluripotency Genes in Bovine Differentiated Cells [0.03%]
激活诱导的胞苷脱氨酶可诱导牛分化细胞多能性基因去甲基化
Song-Yi Moon,Hye-Ju Eun,Sang-Ki Baek et al.
Song-Yi Moon et al.
Activation-induced cytidine deaminase (AID) is the only enzyme that has been suggested as a putative DNA demethylase in mammals. However, very little is known about AID function as DNA demethylase of bovine differentiated cells toward pluri...
The Necessity of OCT-4 and CDX2 for Early Development and Gene Expression Involved in Differentiation of Inner Cell Mass and Trophectoderm Lineages in Bovine Embryos [0.03%]
OCT-4和CDX2在牛胚胎早期发育及内细胞团和滋养外胚层基因表达谱分化中的作用
Nobuyuki Sakurai,Kazuki Takahashi,Natsuko Emura et al.
Nobuyuki Sakurai et al.
The functions of POU class 5 transcription factor 1 (Oct-4) and caudal-type homeobox 2 (Cdx2) in the differentiation of the murine inner cell mass (ICM) and trophectoderm (TE) have been described in detail. However, little is known about th...
Hypoxic Preconditioning Improves the Therapeutic Potential of Aging Bone Marrow Mesenchymal Stem Cells in Streptozotocin-Induced Type-1 Diabetic Mice [0.03%]
缺氧预处理改善骨髓间充质干细胞治疗 streptozotocin 诱导的 i 型糖尿病小鼠的效果
Muhammad Waseem,Irfan Khan,Hana&#x;a Iqbal et al.
Muhammad Waseem et al.
Insulin replacement is the current therapeutic option for type-1 diabetes. However, exogenous insulin cannot precisely represent the normal pattern of insulin secretion. Another therapeutic strategy is transplantation of pancreatic islets, ...