Generation of Induced Pluripotent Stem Cells from a Female Patient with a Xq27.3-q28 Deletion to Establish Disease Models and Identify Therapies [0.03%]
通过来自Xq27.3-q28缺失的女性患者的诱导多能干细胞建立疾病模型和识别治疗方法
Noriko Watanabe,Kohei Kitada,Katherine E Santostefano et al.
Noriko Watanabe et al.
Since it is extremely difficult to establish an animal model for human chromosomal abnormalities, induced pluripotent stem cells (iPSCs) provide a powerful alternative to study underlying mechanisms of these disorders and identify potential...
In Vitro Development and Mitochondrial Gene Expression in Brown Brocket Deer (Mazama gouazoubira) Embryos Obtained by Interspecific Somatic Cell Nuclear Transfer [0.03%]
异种体细胞核移植获得的马扎玛小鹿（Mazama gouazoubira）胚胎的体外发育和线粒体基因表达
Lívia C Magalhães,Jenin V Cortez,Maajid H Bhat et al.
Lívia C Magalhães et al.
The genetic diversity of Neotropical deer is increasingly jeopardized, owing to declining population size. Thus, the formation of cryobanking of somatic cells is important for the preservation of these species using cloning. The transformat...
Hypoxia Enhances Mesenchymal Characteristics Maintenance of Buffalo Bone Marrow-Derived Mesenchymal Stem Cells [0.03%]
缺氧增强水牛骨髓间充质干细胞向间质细胞特性的维持
Jun Zhang,Chuan Lei,Yanfei Deng et al.
Jun Zhang et al.
Bone marrow-derived mesenchymal stem cells (BMSCs) from livestock are valuable resources for veterinary therapeutics and animal reproduction. Previous studies have shown that hypoxic conditions were beneficial in maintaining the mesenchymal...
In Vitro and In Vivo Interspecies Chimera Assay Using Early Pig Embryos [0.03%]
利用早期猪胚胎进行体内外跨物种嵌合体实验
Monika Nowak-Imialek,Stephanie Wunderlich,Doris Herrmann et al.
Monika Nowak-Imialek et al.
Chimeric pigs harboring organs derived from human stem cells are promising for patient-specific regenerative therapies. Induced pluripotent stem cells (iPSCs) can contribute to all cell types of the fetus, including germline after injection...
Roles of Exosomes from Mesenchymal Stem Cells in Treating Osteoarthritis [0.03%]
间充质干细胞外泌体治疗骨关节炎的作用机制研究进展
Jian Wang,Xuanxuan Guo,Zhanrong Kang et al.
Jian Wang et al.
Exosomes are small extracellular vesicles (EVs) with a diameter of 50-150 nm that play important roles in cell-to-cell communication through transportation of proteins, microRNAs, lncRNAs, and mRNAs. Some components, such as miRNAs, have be...
Effect of Aerobic and Resistance Training on Endothelial Progenitor Cells in Mice with Type 2 Diabetes [0.03%]
有氧运动和抗阻训练对2型糖尿病小鼠内皮祖细胞的影响
Xia Dai,Lu Zhai,Qiang Su et al.
Xia Dai et al.
Since no study has explored whether exercise could improve impaired proliferation, migration, and angiogenesis of endothelial progenitor cells (EPCs) in animal models or humans with type 2 diabetes, we aimed to explore the effect of differe...
Induction of Hepatic Regeneration in an Experimental Model Using Hepatocyte-Differentiated Mesenchymal Stem Cells [0.03%]
采用肝细胞分化间充质干细胞诱导肝再生的实验研究
Hanan El Baz,Zeinab Demerdash,Manal Kamel et al.
Hanan El Baz et al.
Mesenchymal stem cell (MSC)-based liver tissue engineering on nanofibrous scaffold holds great promise for cell-based therapy in liver injuries and end-stage liver failure treatments. MSCs were generated from umbilical cord blood. Hepatogen...
Melatonin Enhances the Development of Porcine Cloned Embryos by Improving DNA Methylation Reprogramming [0.03%]
褪黑素通过改善DNA甲基化重编程促进体细胞克隆猪胚胎发育
Jiadan Qu,Mingjun Sun,Xiangyu Wang et al.
Jiadan Qu et al.
Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning efficiency. Melatonin has been proven to improve the development of cloned embryos, however, the role of melatonin during somatic cell nuclear transfer remains...
Differentiation of Urine-Derived Induced Pluripotent Stem Cells to Neurons, Astrocytes, and Microvascular Endothelial Cells from a Diabetic Patient [0.03%]
糖尿病病人尿源诱导多能干细胞向神经元、星形胶质细胞和微血管内皮细胞的分化
Wan Liu,Ping Zhang,Jing Tan et al.
Wan Liu et al.
Complications of central nervous system in type 2 diabetes mellitus (T2DM) often lead to cognitive impairment and seriously affect the quality of life. However, there is no individualized disease model. Urine-derived stem cells can be an id...
Intermediate Standstill Clones Trapped in the Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells [0.03%]
人纤维母细胞重编程为诱导多能干细胞过程中的停滞期克隆捕获现象
Lifei Zhang,Yebo Wang,Ye Zhang et al.
Lifei Zhang et al.
Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) as a powerful tool for regenerative medicine has gained wide attention in recent years. However, there are certain concerns regarding the efficiency o...