Reprogramming Stars #23: Charting Cell Fate Crossroads from the Interplay Between Epigenetics, Transcription, and 3D Chromatin Architecture-An Interview with Dr. Effie Apostolou [0.03%]
从表观遗传学、转录和三维染色质结构之间的相互作用绘制细胞命运十字路口——对Effie Apostolou博士的采访
Effie Apostolou,Mariana Lopes,Carlos-Filipe Pereira
Effie Apostolou
In Vitro Hepatocyte Differentiation of Human Adipose-Derived Stem Cells Under Hypoxia and Photobiomodulation Irradiation [0.03%]
低氧和光生物调节照射下人脂肪来源干细胞的体外肝细胞分化
In-Su Park
In-Su Park
Stem cells may be manipulated in vitro to induce hepatic differentiation. We investigated the effect of hypoxia and photobiomodulation therapy (PBMT) on the hepatogenic differentiation of human adipose-derived stem cells (hASCs). hASCs were...
Transformation of an Olfactory Placode-Derived Cell into One with Stem Cell Characteristics by Disrupting Epigenetic Barriers [0.03%]
通过破坏表观遗传屏障将嗅板衍生细胞转化为具有干细胞特性的细胞
Ghazia Abbas,Rutesh Vyas,Joyce C Noble et al.
Ghazia Abbas et al.
The mammalian olfactory neuronal lineage is regenerative, and accordingly, maintains a population of pluripotent cells that replenish olfactory sensory neurons and other olfactory cell types during the life of the animal. Moreover, in respo...
Reprogramming of Different Cell Lineages into Functional β-Cell Substitutes [0.03%]
不同谱系细胞程序化为有功能的β细胞替代细胞
Anna A Dattoli,Yosip Kelemen,Xiaofeng Huang
Anna A Dattoli
Since its first use in 1922, insulin therapy has transformed diabetes from a fatal disease to a manageable condition. However, long-term insulin injections lead to significant complications. β-cell replacement, derived from either a limite...
Arjun Jain,Yuuki Hosokawa,Kevin Joseph
Arjun Jain
Sahu et al. (2024) demonstrate that targeted partial reprogramming with Oct4, Sox2, and Klf4 (OSK) delivered via adeno-associated virus (AAV) to Cdkn2a-positive cells rejuvenates senescent cells while maintaining cellular identity. In a pro...
Reprogramming Stars #22: Cellular Reprogramming as a Route for Decoding Neurodegenerative Disorders-An Interview with Dr. Janelle Drouin-Ouellet [0.03%]
从细胞重新编程解码神经退行性疾病的路上——对Janelle Drouin-Ouellet博士的采访之星球重组#22
Janelle Drouin-Ouellet,Mariana Lopes,Carlos-Filipe Pereira
Janelle Drouin-Ouellet
Giulia Redi,Filomena Del Piano,Sara Cappellini et al.
Giulia Redi et al.
Neuronal direct cell reprogramming approach allows direct conversion of somatic cells into neurons via forced expression of neuronal cell-lineage transcription factors (TFs). These so-called induced neuronal cells have significant potential...
Rejuvenation to the Heart: Overcoming Age-Related Metabolic Barriers in Direct Cardiac Reprogramming [0.03%]
心之再造：克服年龄相关代谢障碍，直接重编程修复心脏损伤
Pedro P Cunha,Mariana Lopes
Pedro P Cunha
By dissecting metabolic and epigenetic features imposed by ageing in cardiomyocyte conversion from fetal and adult mouse fibroblasts, Santos et al. describe that metabolic modulation can enhance direct cardiac reprogramming. ...
Novel Insights into the Phospholipase C Delta 3 and Its Implications in Neoplastic Diseases [0.03%]
磷脂酶Cδ3的新见解及其在肿瘤性疾病中的意义
Lindi Xu,Zhenli Li,Shuaishuai Zhu et al.
Lindi Xu et al.
The phospholipase C (PLC) family plays a crucial role in the construction of biomembranes, cell growth, and signal transduction. PLC regulates multiple cellular processes by generating bioactive molecules such as inositol-1,4,5-triphosphate...
Old Habits Die Hard: DNA Methylation Patterns Persist in Experimental Transdifferentiation [0.03%]
旧习难改：实验转分化过程中DNA甲基化模式持续存在
Alice E Lord,Leo J Dudley,Lynette Graver et al.
Alice E Lord et al.
The reprogramming of somatic cells into different lineages by transdifferentiation holds great promise for regenerative medicine and replacement therapies. However, a recent report by Radwan et al. (PNAS, 2024) finds that transdifferentiate...