Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion [0.03%]
低成本直接神经元重编程的化学诱导方法——NOG因子替换化合物筛选及优化
Lena Böhnke,Lucia Zhou-Yang,Silvia Pelucchi et al.
Lena Böhnke et al.
The direct conversion of adult human skin fibroblasts (FBs) into induced neurons (iNs) represents a useful technology to generate donor-specific adult-like human neurons. Disease modeling studies rely on the consistently efficient conversio...
The Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus [0.03%]
间充质干细胞在糖尿病治疗中的潜在疗效
Liang Zhu,Sheng Wang,JunSheng Qu et al.
Liang Zhu et al.
Mesenchymal stem cells (MSCs) exist in many tissues and can differentiate into cells of multiple lineages, such as adipocytes, osteoblasts, or chondrocytes. MSC administration has demonstrated therapeutic potential in various degenerative a...
Amphiregulin Supplementation During Pig Oocyte In Vitro Maturation Enhances Subsequent Development of Cloned Embryos by Promoting Cumulus Cell Proliferation [0.03%]
卵母细胞体外成熟过程中补充Amphiregulin通过促进放射冠细胞增殖促进克隆胚胎的发育
Xianjun Zhang,Huaxing Zhao,Yanan Li et al.
Xianjun Zhang et al.
The oocyte in vitro maturation (IVM) technique is important in animal husbandry, biomedicine, and human-assisted reproduction. However, the developmental potential of in vitro matured oocytes is usually lower than that of in vivo matured (I...
Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells [0.03%]
直接重编程不同谱系细胞成为类似胰岛β细胞
Jonathan L Colarusso,Qiao Zhou
Jonathan L Colarusso
One major goal of regenerative medicine is the production of pancreatic endocrine islets to treat insulin-dependent diabetic patients. Among the different methods developed to achieve this goal, a particularly promising approach is direct l...
Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming [0.03%]
利用由直接重编程生成的患者源诱导神经元构建肌线粒体脑肌病、乳酸酸中毒和中风类似发作综合征模型
Suleva Povea-Cabello,Marina Villanueva-Paz,Irene Villalón-García et al.
Suleva Povea-Cabello et al.
Mitochondrial diseases are a heterogeneous group of rare genetic disorders caused by mutations in nuclear or mitochondrial DNA (mtDNA). These diseases are frequently multisystemic, although mainly affect tissues that require large amounts o...
Deducing Insulin-Producing Cells from Goat Adipose Tissue-Derived Mesenchymal Stem Cells [0.03%]
从山羊脂肪组织中分离的间充质干细胞向胰岛素产生细胞分化的研究
Amit Dubey,Sikander Saini,Vishal Sharma et al.
Amit Dubey et al.
Mesenchymal stem cell is a potent tool for regenerative medicine against control of incurable diseases in human and animals. Diabetes mellitus is one such condition marked with the blood glucose is high due to lack of insulin (INS) hormone ...
Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts [0.03%]
GATA4外源性表达的合适比例是人真皮纤维母细胞重编程为心脏起搏细胞的重要因素
Xiangyu Zhang,Qi Zhang,Lijun Chen et al.
Xiangyu Zhang et al.
Reprogramming of human dermal fibroblasts (HDFs) into induced cardiomyocyte-like cells (iCMs) represents a promising strategy for human cardiac regeneration. Different cocktails of cardiac transcription factors can convert HDFs into iCMs, a...
Signaling Pathways and Protein-Protein Interaction of Vimentin in Invasive and Migration Cells: A Review [0.03%]
波形蛋白在细胞侵袭和迁移中的信号通路及蛋白质相互作用：综述研究
Danial Hashemi Karoii,Hossein Azizi,Mahdi Amirian
Danial Hashemi Karoii
The vimentin (encoded by VIM) is one of the 70 human intermediate filaments (IFs), building highly dynamic and cell-type-specific web networks in the cytoplasm. Vim-/- mice exhibit process defects associated with cell differentiation, which...
Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming [0.03%]
利用直接神经重编程进行神经系统退行性疾病建模
Emilie M Legault,Julie Bouquety,Janelle Drouin-Ouellet
Emilie M Legault
Understanding the pathophysiology of CNS-associated neurological diseases has been hampered by the inaccessibility of patient brain tissue to perform live analyses at the molecular level. To this end, neural cells obtained by differentiatio...
Hongxia Xu,Xuguang Wang,Ruixin Tao et al.
Hongxia Xu et al.
Different development stages of porcine embryos have different tolerance to low temperature. Therefore, we took the porcine embryos after parthenogenetic activation (PA) as the model, to explore the optimal development stage for vitrificati...