HPV16 recruitment of SMARCAL1 to viral and host replication forks is required for the viral life cycle [0.03%]
HPV16募集SMARCAL1到病毒和宿主复制叉上对其生命周期是必需的
Claire D James,Aya H Youssef,Jenny D Roe et al.
Claire D James et al.
High-risk human papillomaviruses (HR HPVs) are responsible for around 5% of the world's cancer burden. Activation and interaction with the host DNA damage response (DDR) promote the HPV16 life cycle. This study demonstrates a crucial intera...
Non-suppressible HIV viremia sustained by clonally expanded CD4+ T cells harboring a genomically defective provirus with an immune-evasive protein expression profile [0.03%]
克隆扩增的CD4⁺T细胞携带有基因缺陷但能逃避免疫攻击的潜伏型HIV病毒导致无法抑制的HIV病毒血症
F Harrison Omondi,Yurou Sang,Winnie Dong et al.
F Harrison Omondi et al.
Antiretroviral therapy (ART) potently inhibits HIV replication but does not eliminate HIV proviruses integrated within the genomes of infected cells. Though ART normally suppresses HIV to clinically undetectable levels in blood, some indivi...
Identification of two Wolbachia genes with cell proliferation-inhibitory activity in Ostrinia cultured cells [0.03%]
两种沃尔巴克氏体基因具有抑制亚洲玉米螟细胞培养增殖的作用
Susumu Katsuma,Noriko Matsuda-Imai,Tomohiro Muro et al.
Susumu Katsuma et al.
Wolbachia species are endosymbiotic bacteria that regulate the sexual development and reproduction of their insect hosts. Despite their biological importance, functional analyses of Wolbachia genes remain limited, largely due to the absence...
The repertoire of resistance mutations selected by a Pseudomonas aeruginosa type IV pilus-targeting lytic bacteriophage [0.03%]
针对铜绿假单胞菌型IV菌毛的裂解噬菌体所选择的耐药突变谱系
Veronica N Tran,Hanjeong Harvey,Tanisha S Lahane et al.
Veronica N Tran et al.
Pseudomonas aeruginosa type IV pili (T4P) are complex surface-exposed nanomachines used for twitching motility and biofilm formation. Exposure to bacteriophages that use T4P as their primary receptor can select for resistance mutations that...
Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein [0.03%]
酪氨酸激酶LYN通过直接磷酸化病毒核蛋白限制甲型流感病毒的复制和毒力
Junwen Liu,Jiaxin Huang,Qian Wang et al.
Junwen Liu et al.
The continuous antigenic shift and drift of influenza A virus (IAV) result in the emergence of novel strains and drug resistance. Accordingly, it is urgent to develop novel antiviral drugs that target host factors. Here, we revealed that ty...
Structural and functional analysis of the Bacillus cereus GerI inosine-responsive spore germinant receptor [0.03%]
伯克霍尔德菌冰晶蓝素色素座基因簇的鉴定及功能分析
Yunfeng Li,Giannina Ow-Young-Villarreal,Yulia Pustovalova et al.
Yunfeng Li et al.
Bacterial endospores are metabolically dormant yet can rapidly return to vegetative growth upon exposure to nutrients through the process of germination. Spore germination is triggered by specific chemical nutrients binding to cognate germi...
Maneesh Paul Satyaseela
Maneesh Paul Satyaseela
Antimicrobial resistance (AMR) is the ability of microbes to survive exposure to antimicrobials that were once effective against them. This is a major global crisis and public health challenge of the 21st century that is declared as a silen...
Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein [0.03%]
分泌型全长人Prosaposin(PSAP)通过促进刺突蛋白S1亚基的释放抑制SARS-CoV-2感染
Chongyang Zhang,Peiwen Ding,Xia Xiao et al.
Chongyang Zhang et al.
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted global public health and the economy. Systematic screening of host factors influencing viral infection is critical for un...
In situ architecture of the Tad pilus machine in Caulobacter crescentus [0.03%]
环形拟序细菌中的Tad丝状体机器的原位结构
James Iarocci,Gregory B Whitfield,Ryu F Williston et al.
James Iarocci et al.
The tight adherence (Tad) pilus is a broadly distributed and evolutionarily distinct subclass of type IV pili that mediate cell adhesion, biofilm formation, predation, and surface sensing in many bacteria, including Caulobacter crescentus, ...
Cytokine-driven PANoptosis of alveolar macrophages mediated by STAT1 underlies acute lung injury in hypervirulent Klebsiella pneumoniae infection [0.03%]
高毒力肺炎克雷伯菌感染中STAT1介导的肺泡巨噬细胞细胞因子驱动PANoptosis在急性肺损伤中的作用
Qi Xu,Xiaoxuan Liu,Heng Heng et al.
Qi Xu et al.
Understanding the fundamental mechanisms that govern innate immune and inflammatory responses during Klebsiella pneumoniae (Kp) infection is critical for developing effective therapeutic strategies against this public health threat. We foun...