Landscape and dynamics of TadA-dependent RNA editing in Escherichia coli reveal a role in nutrient-rich growth [0.03%]
TadA依赖型RNA编辑在大肠杆菌中的景观和动态揭示了其在营养丰富环境下的作用
Danielle Arad,Ofir Fargeon,Liron Levin et al.
Danielle Arad et al.
Adenosine-to-inosine (A-to-I) mRNA editing alters genetic information post-transcriptionally and can impact protein sequence and function, yet its regulation in bacteria remains unclear. Here, we profiled A-to-I editing in Escherichia coli ...
AexB is an aromatic amino acid exporter that functions as a metabolic safety valve [0.03%]
AexB是一个芳香族氨基酸出口蛋白 能够作为代谢安全阀发挥作用
Blake A Everett,Arthur Prindle
Blake A Everett
Aromatic amino acids-tryptophan, tyrosine, phenylalanine, and histidine-are essential for bacterial growth and are among the most energetically expensive metabolites to synthesize. Despite this cost, it has been recently shown that bacteria...
Global translational and metabolic remodeling during iron deprivation in Toxoplasma gondii [0.03%]
溶贫条件下Toxoplasma gondii的全局翻译和代谢重塑
Jack C Hanna,Shikha Shikha,Megan A Sloan et al.
Jack C Hanna et al.
Iron is required to support essential cellular processes. Due to diverse and dynamic host environments, the obligate intracellular parasite Toxoplasma gondii must adapt to iron-limited conditions. To investigate the adaptations critical to ...
TRIM25 promotes antiviral innate immune response by stabilizing IRF7 and its nuclear translocation [0.03%]
TRIM25通过稳定IRF7并促进其核转位来促进抗病毒固有免疫反应
Zhen Wu,Yingxuan Cui,Yu He et al.
Zhen Wu et al.
Most avian species lack interferon regulatory factor 3 (IRF3), a key transcription factor that initiates antiviral interferon responses, leaving how they achieve rapid RNA virus defense unclear. Here, we identify duck tripartite motif conta...
A protein disulfide isomerase coordinates redox homeostasis and ER calcium regulation for optimal lytic cycle progression in Toxoplasma gondii [0.03%]
一个蛋白质二硫化物异构酶协调了红氧平衡和内质网钙调节以适应弓形虫裂殖周期的最佳进行状态
Katherine E Moen,Silvia N J Moreno
Katherine E Moen
The endoplasmic reticulum (ER) maintains an oxidative environment that facilitates the formation of disulfide bonds, a critical process for proper protein folding. Protein disulfide isomerases (PDIs) are ER-resident enzymes that facilitate ...
Evolution uncovers a general tradeoff between recovery after heat shock and growth at elevated temperatures [0.03%]
进化发现热休克后的恢复与高温下的生长之间存在普遍的权衡关系
Akshat Mall,Katelyn J Rode,Christopher J Marx
Akshat Mall
Fitness tradeoffs between different environments enable the maintenance of microbial diversity. While the importance of tradeoffs is clear, it has been surprisingly difficult to predict which traits they will occur between and at how granul...
The transcriptional repressor Ssn6 modulates phase separation to regulate fungal gene expression [0.03%]
转录阻遏物Ssn6通过调节相分离来调控真菌基因表达
Maureen A Dowell,Mae I Staples,Corey Frazer et al.
Maureen A Dowell et al.
The transcriptional regulation of cell fate plays a central role in eukaryotic cell differentiation. In the human fungal pathogen Candida albicans, the white-to-opaque cell fate switch is controlled by an interconnected network of eight tra...
Pharmacological reduction of neutrophil infiltration reduces Clostridioides difficile infection severity [0.03%]
中和剂减少嗜中性粒细胞浸润可降低难辨梭菌感染的严重程度
Orlaith Keenan,Joshua Soto Ocaña,Alexa Semon et al.
Orlaith Keenan et al.
Clostridioides difficile is the leading cause of nosocomial infections and an urgent public health threat. This bacterial pathogen is challenging to treat due to antibiotic resistance and high recurrence rates, highlighting the need for add...
HIV Nef-mediated WAVE2-ARP2/3 inhibition underlies CD4+ T-cell lamellipodial abnormalities and immune dysfunction [0.03%]
Nef通过抑制WAVE2-ARP2／3而引起CD4⁺T细胞伪足形成缺陷和免疫功能障碍
Daniel C Dunn,Jacqueline M Crater,Perla M Del Río Estrada et al.
Daniel C Dunn et al.
CD4+ T cells are central regulators of adaptive immune responses, and their depletion following HIV infection leads to AIDS. HIV Nef and Gag weaken CD4+ T cells by disrupting the actin cytoskeleton, which leads to impaired cell migration an...
mGem: Cut4/Apc1 and its prion form at the cross roads of cell cycle regulation, heterochromatin organization, RNAi, stress response, and evolution [0.03%]
mGem：Cut4/Apc1及其朊病毒形式位于细胞周期调控、异染色质组织、RNA干扰、应激反应和进化交叉点上
Suman Sharma,Jagmohan Singh
Suman Sharma
The anaphase-promoting complex/cyclosome (APC/C) complex plays a pivotal role in cell cycle progression in eukaryotes. APC/C-mediated polyubiquitination and subsequent degradation of regulatory factors ensure sister chromatid separation dur...