mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic [0.03%]
mGem：COVID-19大流行背景下金黄色葡萄球菌败血症的群体基因组学研究
Miquel Sánchez-Osuna,Ana Beatriz Garcez Buiatte,Rebecca Wang et al.
Miquel Sánchez-Osuna et al.
The pressure of the coronavirus disease 2019 (COVID-19) pandemic on global healthcare systems and societies was unprecedented in the modern era. Social restrictions, containment measures, and disruptions in antimicrobial prescriptions and c...
Linker histone H1.2 inhibits HSV-1-induced IFN response via cGAS [0.03%]
linker 历组蛋白 H1.2 通过 cGAS 抑制 HSV-1 诱导的 IFN 反应
Sirui Li,Chenglong Li,Fengyi Zhou et al.
Sirui Li et al.
Linker histone H1.2 (H1.2), as a member of the histone H1 family involved in many cellular physiological regulatory functions, plays a vital role in maintaining nucleosome and chromatin stability. Cyclic GMP-AMP synthase (cGAS) is a critica...
High-density microdroplet cultivation reveals the essential role of microbial interactions in the growth of environmental microbes [0.03%]
高密度微滴培养揭示了微生物相互作用在环境微生物生长中的重要作用
Eun-Young Seo,Rikuta Suzuki,Yuki Takagi et al.
Eun-Young Seo et al.
The significance of microbial interactions in nature is not well understood because of technical limitations in observing how individual microbial cells begin to grow within complex microbial community. To address this limitation for furthe...
A new highly discriminatory typing scheme for Treponema pallidum reveals similar levels of genetic variability across lineages [0.03%]
一种新的Treponema pallidum分型方案具有高度区分度，显示各谱系间的遗传变异水平相似
Marta Pla-Díaz,Lorenzo Giacani,Lauren C Tantalo et al.
Marta Pla-Díaz et al.
The global resurgence of treponematoses, particularly syphilis, poses a growing public health challenge. Despite advances in sequencing technologies, obtaining complete Treponema pallidum genome sequences for epidemiological studies remains...
A Val292 substitution combined with an alanine duplication (ADUP) in the Ω loop of ADC β-lactamase confers reduced susceptibility to advanced β-lactam agents, including cefiderocol [0.03%]
Ω环中ADCβ内酰胺酶的Val292替代和 Ala插入（ADUP）突变体使包括谢西地kol在内的新型β-内酰胺药物产生耐药性
Akito Kawai,Christi L McElheny,Ryan K Shields et al.
Akito Kawai et al.
Intrinsic Acinetobacter-derived cephalosporinases (ADCs) in Acinetobacter baumannii are AmpC-type β-lactamases that confer resistance to β-lactam agents, typically through insertion sequence (IS) element-driven overexpression. However, th...
Manipulation of regulators of morphogenesis is not sufficient to render a Candida albicans colonizer strain pathogenic [0.03%]
对形态发生的调节因子进行操作不足以使卡式肺囊虫的定植菌株致病
Ricardo Fróis-Martins,Sarah Mertens,Van Du T Tran et al.
Ricardo Fróis-Martins et al.
As a member of the microbiome, Candida albicans colonizes the oral cavity and other mucosal surfaces of the human body. While commensalism is tightly controlled by the host immune system, the fungal determinants enabling the fungus to colon...
Regulation of RNase PH during nutrient deprivation: the role of proteases, GroEL, and RNase II [0.03%]
营养缺乏条件下调控RNase PH：蛋白酶、GroEL和RNase II的功能分析
Ashraf Hussain,Murray P Deutscher
Ashraf Hussain
RNase PH is a critical exoribonuclease in Escherichia coli that participates in tRNA maturation and RNA degradation. In earlier work, it was observed that levels of RNase PH decreased as much as 90% under conditions of nutrient deprivation,...
Mutation of lysine 396 of the fusion protein reduces its binding affinity with integrin αVβ1 and leads to attenuation of avian metapneumovirus subtype B [0.03%]
融合蛋白赖氨酸396突变降低了其与整合素αVβ1的亲和力并导致副鸡嗜呼吸道病毒亚型B弱毒化
Lingzhai Meng,Yuntong Chen,Mengmeng Yu et al.
Lingzhai Meng et al.
Avian metapneumovirus subtype B (aMPV/B) infections significantly affect the global poultry industry. However, the virulence determinants and attenuation mechanism remain unknown. Here, a series of chimeric and mutant viruses was constructe...
T cell responses to nonstructural proteins promote cross-serotype immunity to foot-and-mouth disease virus [0.03%]
针对非结构蛋白的T细胞反应促进口蹄疫病毒交叉血清型免疫性
Suyu Mu,Shaobin Shang,Hu Dong et al.
Suyu Mu et al.
T-cell responses play a pivotal role in protection against foot-and-mouth disease virus (FMDV), by enhancing neutralizing antibody (NAb) titers and shortening the duration of infection. To further elucidate the protective immune mechanisms ...
Magnetosome organelles are organized through interactions between McaA and McaB that alter the dynamics of the bacterial actin-like protein MamK [0.03%]
麦加A和麦加B的相互作用通过改变细菌肌动蛋白类似物MamK的动力学来组织磁小体器官原质体
Yein Ra,Yuanyuan Pan,Tansy Chen et al.
Yein Ra et al.
Magnetotactic bacteria (MTB) are a group of gram-negative species that produce a lipid-bounded organelle, the magnetosome, in which a magnetic crystal is biomineralized. MTB use magnetosomes to align with the geomagnetic field for improved ...