A fusion protein's weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion protein [0.03%]
融合蛋白的薄弱环节：抑制性肽与副流感病毒融合蛋白相互作用揭示的功能限制
Maximilian Crosby,Ariel J Kuhn,Gillian Zipursky et al.
Maximilian Crosby et al.
Human parainfluenza viruses (HPIVs) cause significant respiratory illnesses including croup and pneumonia. HPIV infection begins with fusion of viral and host cell membranes, driven by the coordinated actions of the attachment (HN) and fusi...
Lysophospholipid signaling coordinates outer membrane homeostasis in Escherichia coli [0.03%]
溶血磷脂信号协调大肠杆菌外膜稳态
Gerald R Enverso,M Stephen Trent
Gerald R Enverso
The Gram-negative outer membrane (OM) is an asymmetric bilayer that protects cells from environmental stress and antibiotics. This asymmetry, with lipopolysaccharide (LPS) in the outer leaflet and glycerophospholipids (GPLs) in the inner le...
Correction for Pfannenstiel et al., "Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication" [0.03%]
对Pfannenstiel等人文章的更正：“识别一系列基于吡咯并咪唑的SARS-CoV-2 Mac1抑制剂以抑制冠状病毒复制”
Jessica J Pfannenstiel,Men Thi Hoai Duong,Daniel Cluff et al.
Jessica J Pfannenstiel et al.
Published Erratum
mBio. 2026 Apr 14:e0086526. DOI:10.1128/mbio.00865-26 2026
Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies [0.03%]
群体对H5N1病毒2.3.4.4b谱系的免疫力主要由抗神经氨酸酶抗体介导
Gagandeep Singh,Disha Bhavsar,Enikö Hermann et al.
Gagandeep Singh et al.
Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses continue to expand geographically and across mammalian hosts, raising concern about pandemic potential. The degree and specificity of pre-existing immunity in humans are key d...
Fc-engineered antibodies enhance protection against SARS-CoV-2 lung infection and inflammation [0.03%]
工程抗体改善对新冠病毒肺部感染和炎症的抵抗作用
Samantha R Mackin,Chieh-Yu Liang,Courtney E Karl et al.
Samantha R Mackin et al.
As the SARS-CoV-2 pandemic progressed, many monoclonal antibodies (mAbs) that neutralized infection against initial strains lost potency against later variants due to the accumulation of mutations in the spike protein. Nonetheless, some mAb...
Metabolically diverse microorganisms mediating hydrocarbon cycling in the subseafloor sediment of the Challenger Deep [0.03%]
挑战者深渊海底沉积物中调控烃类循环的代谢多样的微生物群落
Xinxin He,Jiwen Liu,Haojin Cheng et al.
Xinxin He et al.
Hadal subseafloor sediments host abundant and active microbial biosphere with considerable heterotrophic activity. However, carbon and nutrient cycling processes and mechanisms driven by hadal subsurface microorganisms remain poorly underst...
Pathophysiology of intracranial hypertension in cryptococcal meningoencephalitis [0.03%]
新隐球菌脑膜脑炎颅内高压的发生机制
Arie Van Wieren,Arturo Casadevall
Arie Van Wieren
Cryptococcal meningoencephalitis (CME) is a major cause of death and disability, and intracranial hypertension is a leading, treatable contributor to mortality and neurologic sequelae. Across CME cohorts, markedly elevated cerebrospinal flu...
Inactivation of a purine biosynthesis repressor promotes ribosome synthesis to overcome antibiotic stress [0.03%]
嘌呤生物合成阻遏蛋白失活可促进核糖体生成以克服抗生素胁迫
Alexandre Le Scornet,Yongjun Tan,Dapeng Zhang et al.
Alexandre Le Scornet et al.
Macrolide, lincosamide, and streptogramin (MLS) antibiotics are structurally distinct molecules that inhibit protein synthesis by binding overlapping sites within the 23S rRNA of bacterial ribosomes. The clinical utility of MLS antibiotics ...
When culture-based whole-genome sequencing can change management in severe ocular bacterial infections [0.03%]
基于文化的全基因组测序在严重眼部细菌感染中的管理改变时机
Inès Fenniri,Camille André
Inès Fenniri
Nationwide multicenter surveillance demonstrates a substantial burden of antimicrobial resistance among ocular bacterial pathogens. In the 2009-2018 ARMOR collection, methicillin-resistant Staphylococcus aureus (MRSA) accounted for 34.9% of...
Beneficial impact of acquired AmpC β-lactamases on bacterial fitness and pathogenicity: a new paradigm [0.03%]
获得性AmpCβ-内酰胺酶对细菌适应度和致病性的有利影响：一种新的范式
Otávio Hallal Ferreira Raro,Charlotte Michaux,Andrea Endimiani et al.
Otávio Hallal Ferreira Raro et al.
AmpC-type β-lactamases share structural similarities with penicillin-binding proteins, supporting the view that both enzyme families evolved from a common ancestor. Considering the widespread dissemination of acquired AmpCs in Gram-negativ...