Plasmodium falciparum hemozoin-associated biomolecules induce brain endothelial cell barrier disruption in an in vitro model of cerebral malaria [0.03%]
一种体外疟疾脑水肿模型中 Plasmodium falciparum 血红素诱导脑内皮细胞屏障受损作用的研究
Kelly A Crotty,Ioana Clotea,Beatrix Ueberheide et al.
Kelly A Crotty et al.
Cerebral malaria is a major complication of Plasmodium falciparum infection that occurs upon the sequestration of infected red blood cells (iRBCs) in brain capillaries, resulting in the loss of endothelial barrier integrity, brain swelling,...
William Hamilton,Erin Hardy,Sergio López-Madrigal et al.
William Hamilton et al.
Arthropods, the most diverse phylum on Earth, are hosts to a plethora of bacterial parasites that secrete various effectors of unknown function during infection. The most prevalent of these is the intracellular bacterium Wolbachia pipientis...
Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen Candida albicans [0.03%]
白念珠菌中的Met32调控硫代谢的灵活性和抵抗反应性硫物质的能力
Anagha C T Menon,Faiza Tebbji,Mélanie Mecteau et al.
Anagha C T Menon et al.
Although considerable advances have been made in understanding the metabolic machinery that enables bacteria to utilize sulfur sources, our understanding of the corresponding processes in fungi remains comparatively fragmentary. To explore ...
Loss of Pol32, a subunit of DNA polymerases δ and ζ, leads to different patterns of genome stability than direct impairment of these individual polymerases [0.03%]
POL32缺失导致的基因组不稳定性与单独抑制DNA聚合酶δ或ζ不同
Lei Qi,Ke-Jing Li,Xing-Xing Tang et al.
Lei Qi et al.
Pol32 is a subunit shared by DNA polymerases δ and ζ, yet its role in maintaining genome integrity remains incompletely defined. Here, we employed whole-genome sequencing of mutation-accumulation lines to systematically characterize the g...
Transcriptomic and functional analyses uncover a conserved effector driving genotype-dependent virulence in the Sphaerulina musiva-Populus trichocarpa interaction [0.03%]
转录组和功能分析揭示了一个保守的作用物驱动了Sphaerulina musiva- Populus trichocarpa互作中的基于基因型的毒力作用
Kelsey L Søndreli,Tomás A Rush,Milton T Drott et al.
Kelsey L Søndreli et al.
The introduction of invasive microbes compromises the structure, biodiversity, and function of naïve ecosystems. Sphaerulina musiva, a hemibiotrophic pathogen that causes leaf spot and stem cankers in Populus species, exemplifies an invasi...
Hélèna Choltus,Niccolo Bianchi,Julien Prados et al.
Hélèna Choltus et al.
Tissue resident host responses to microbial infections in the respiratory tract are highly dynamic in space and time and rely on the interaction of a multitude of cell types. To model these multicellular responses reliably in cell culture, ...
γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction in Streptomyces coelicolor A3(2) [0.03%]
γ-丁内酯诱导的共凝菌素合成通过抑制AtrA依赖性的放线菌红素过量生产来控制链霉菌生长发育和次级代谢产物合成
Bartosz Bednarz,Magdalena Kotowska,Mateusz Wenecki et al.
Bartosz Bednarz et al.
Streptomyces coelicolor A3(2) is a highly potent model antibiotic producer, with a chromosome harboring at least 20 secondary metabolite biosynthetic gene clusters (BGCs). Precise control of these multiple pathways is provided by a complex ...
FtsZ forms biomolecular condensates in a polar-growing Alphaproteobacterium [0.03%]
FtsZ在极性生长的阿尔法变形菌中形成生物分子凝聚体
Todd A Cameron,Miguel Ángel Robles-Ramos,Lorenzo Suigo et al.
Todd A Cameron et al.
The conserved tubulin homolog FtsZ assembles into GTP-dependent protofilaments that organize the bacterial cell division machinery. Purified Escherichia coli FtsZ (FtsZEc) can form biomolecular condensates in the absence of GTP in macromole...
Molecular insights into the dual activation of PomZ, a ParA/MinD P-loop ATPase, by the two ATPase-activating proteins PomX and PomY [0.03%]
PomZ的双重激活机制研究——ATP酶活化蛋白PomX和PomY对ParA/MinD家族P-loop型ATP酶的激活作用的分子机理研究
Philipp Klos,Andrea Harms,Lotte Søgaard-Andersen
Philipp Klos
Positioning of the division site is precisely regulated. In Myxococcus xanthus, the PomX/Y/Z assembly associates with and translocates across the nucleoid in a PomZ ATPase-dependent manner to position the cytokinetic FtsZ ring at midcell. U...
Harnessing random peptide mixtures to combat multidrug-resistant fungal infections [0.03%]
利用随机肽混合物对抗多重耐药性真菌感染
John Adeoye,Yael Belo,Marina Campos Rocha et al.
John Adeoye et al.
Invasive fungal infections are associated with high mortality and are increasingly difficult to treat due to a limited antifungal arsenal and the rapid emergence of drug resistance. Novel therapeutic strategies that combine potent antifunga...