Protein QID74 protects the cell wall of Trichoderma from degradation caused by its own chitinase, which lacks a carbohydrate-binding module [0.03%]
蛋白质QID74保护木霉细胞壁免遭其自身缺乏碳水化合物结合模块的几丁质酶降解
Jun-Jin Deng,Zhao-Fu Chen,Ming-Shu Zhang et al.
Jun-Jin Deng et al.
The fungal cell wall, formed by a chitin backbone, is critical for cellular integrity and environmental fitness. Mycoparasitic fungi of the genus Trichoderma deploy an arsenal of potent chitinases to dismantle the cell walls of prey fungi. ...
High-throughput screening reveals mechanisms of environmental control of germination in a fungal thermophile [0.03%]
高通量筛选揭示环境控制丝状真菌孢子萌发的机制
Olusola A Ogunyewo,Kristopher Fleming,Madeleine Morris et al.
Olusola A Ogunyewo et al.
Thermothelomyces thermophilus is a filamentous fungus isolated from self-heating compost. Unlike most of the fungal kingdom, this species exhibits a growth optimum at 45°C and is intolerant of temperatures below 30°C. To investigate genet...
Lysine benzoylation of fatty acid β-oxidation core enzyme FoxA regulates the aflatoxin biosynthesis by benzoyltransferase EsaA in the pathogenic fungus Aspergillus flavus [0.03%]
黄曲霉病原菌中脂肪酸β氧化核心酶FoxA的赖氨酸苯甲酰化通过苯甲酰转移酶EsaA调控黄曲霉素生物合成
Xuan Chen,Shuqi Huang,Zhiwei Jiang et al.
Xuan Chen et al.
Lysine benzoylation (Kbz) is a newly identified post-translational modification, which participates in the regulation of a variety of cellular processes. However, the function of Kbz in pathogenic fungi remains unclear. Here, we first ident...
Deanna L Mendez,Pema L Childs,Amidala J Martinie et al.
Deanna L Mendez et al.
The unique composition of bacterial electron transport chains (ETCs), distinct from the human mitochondrial ETC, presents opportunities for selective antibacterial targeting. Recently, inhibitors of bacterial ETCs have shown promise as pote...
Staphylococcus aureus can degrade exogenous fatty acids through β-oxidation [0.03%]
金黄色葡萄球菌可以通过β氧化降解外源脂肪酸
Cindy Menjivar,Clarissa Shoffler,Christopher Petucci et al.
Cindy Menjivar et al.
Staphylococcus aureus has long been thought to lack a functional fatty acid degradation (Fad) pathway despite the presence of a locus annotated with the necessary fad genes; however, two recent studies have examined the fad operon for the f...
Innate immune responses to Borrelia burgdorferi during tick-feeding: mechanistic insights relevant to Lyme disease [0.03%]
硬蜱取血时宿主对伯氏疏螺旋体的固有免疫反应及其对于莱姆病的相关机制研究
Suman Kundu,Greg Joyner,Maria Gomes-Solecki
Suman Kundu
Immune responses to tick-transmitted Borrelia burgdorferi (Bb) have not been characterized in vivo. We analyzed the reservoir host's local and systemic immune responses to Bb during tick feeding. C3H/HeN mice were challenged via infected or...
Utilization of a CRISPRi-based ex vivo challenge model to reveal temporally dependent gene essentiality in intracellular Mycobacterium tuberculosis [0.03%]
利用CRISPRi介导的体外感染模型揭示胞内结核杆菌存在时间依赖性的基因必需性
Monique E Theriault,Andrew I Wong,Michael A DeJesus et al.
Monique E Theriault et al.
Mycobacterium tuberculosis (Mtb) remains a leading cause of infectious disease mortality worldwide, largely due to its ability to survive within host macrophages. Despite advances in understanding the environmental pressures Mtb encounters ...
Keith Yamada,Arina Koroleva,Heli Tirkkonen et al.
Keith Yamada et al.
Microbial predators obtain energy from killing other living cells. Streptomyces are soil bacteria that are known to produce numerous catabolic enzymes and antimicrobial compounds to defend against competing organisms. Here, we demonstrate t...
Vacuolar iron export alters the synergy between doxycycline and fluconazole by affecting cidal ROS levels in Candida albicans [0.03%]
铁流出体改变空泡菌株中多西环素和氟康唑联合应用的协同作用机制：通过影响念珠菌胞内ROS水平所致
Wouter Van Genechten,Michelle Holtappels,Martine De Jonge et al.
Wouter Van Genechten et al.
Fungal infections are combatted using three main classes of antifungals, of which the azoles, considered to be fungistatic, are the most widely used. Slow growth of Candida albicans at supra-minimal inhibitory concentrations (MIC) of flucon...
A beneficial endornavirus enhances the fitness of the phytopathogenic fungus Rhizotonia solani [0.03%]
有益内病毒可增强植物病原真菌根霉的适应性
Tianxing Pang,Bokang Li,Qianqian Sun et al.
Tianxing Pang et al.
Although viruses are primarily characterized as pathogenic agents, certain viruses confer advantages to their hosts. The extent to which a virus can improve host biological performance, however, remains a fascinating topic in virology. An e...