Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection [0.03%]
Yoon-Suk Kang,James E Kirby
Yoon-Suk Kang
In this study, we investigated the impact of G protein-coupled receptor (GPCR) signaling on the intracellular replication of the model pathogen Brucella neotomae. Building on a prior chemical genetics screen, we identified agonists of the G...
Stephanie M Marroquin,Shirli Cohen,Melody N Neely et al.
Stephanie M Marroquin et al.
Streptococcus agalactiae, or group B Streptococcus (GBS), is an opportunistic pathogen that asymptomatically colonizes the vaginal tract of up to 30% of healthy individuals. However, during pregnancy, it is associated with adverse pregnancy...
Robust ammonia oxidation by " Candidatus Nitrosacidococcus tergens" across a broad pH range [0.03%]
耐酸氨氧化新载体细菌"Candidatus Nitrosacidococcus tergens"的分离及培养
Ida F Peterse,Claudia Frey,Reinier A Egas et al.
Ida F Peterse et al.
Acidophilic ammonia-oxidizing bacteria (AOB) have only recently been discovered. These organisms hold great promise for acidic wastewater treatment; however, their physiology remains poorly understood compared to that of neutrophilic AOB. H...
Major type IV pilin of Legionella pneumophila enhances bacterial iron acquisition/assimilation, independently of its role in piliation [0.03%]
Legionella pneumophila 主要IV型菌毛蛋白独立于其介导菌毛装配的功能促进细菌铁的获得/同化
Armando Barajas,Joshua Mayoral,Nicholas P Cianciotto
Armando Barajas
We identified a locus within the genome of Legionella pneumophila strain 130b that encodes two related type IV pilins, PilA1 and PilA2. Based on in silico analyses, both proteins were predicted to be major pilins in all L. pneumophila strai...
Phylogenetic diversity, functional pathways, and network interactions of ocular chlamydia-like organisms (CLOs) in trachoma-endemic Ethiopia [0.03%]
埃塞俄比亚沙眼流行地区眼部类似衣原体生物的系统发育多样性、功能通路和网络相互作用
Olusola Olagoke,Xinhe Zheng,Seongwon Chung et al.
Olusola Olagoke et al.
Trachoma is the leading infectious cause of blindness worldwide and classically attributed to Chlamydia trachomatis (Ct). However, other members of the phylum Chlamydiae, particularly environmental chlamydia-like organisms (CLOs), may modul...
Mechanical deformation inhibits growth and migration of S. aureus within submicrometer channels [0.03%]
机械变形可抑制金黄色葡萄球菌在亚微米通道内的生长和迁移
Kelsey G DeFrates,Junsung Lee,Gissell Jimenez et al.
Kelsey G DeFrates et al.
Bacteria colonize surfaces in the environment and can also penetrate tissues and materials by entering micro- and nano-scale cracks and pores. Staphylococcus aureus has been observed within nanoscale channels in bone that are 2-3 times smal...
Emergence of vaccine-derived poliovirus strains from the novel oral polio vaccine in the Central African Republic [0.03%]
中非共和国新型口服脊髓灰质炎疫苗衍生病毒株的出现
Joël W Doté,Marie-Line Joffret,Arthur Mazitchi et al.
Joël W Doté et al.
The Central African Republic (CAR) is a high-risk country for poliomyelitis outbreaks because of difficulties in closing immunity gaps due to the lack of resources, logistics issues, and insecurity. The country experienced multiple poliomye...
Pyrophosphate homeostasis in multiple subcellular compartments is essential in Plasmodium falciparum [0.03%]
疟原虫中多个亚细胞隔室中的焦磷酸盐稳态至关重要
Ikechukwu Nwankwo,Hangjun Ke
Ikechukwu Nwankwo
Pyrophosphate is a byproduct of numerous cellular reactions that use ATP or other nucleoside triphosphates to synthesize DNA, RNA, protein, and various molecules. Its degradation into monophosphate is thus crucial for the survival and proli...
Multiple clades of regulators contribute to bacterial phosphate homeostasis and Staphylococcus aureus pathogenesis [0.03%]
多个调节因子谱系参与细菌磷酸盐稳态和金黄色葡萄球菌致病性
Caroline Vermilya,Eliot S Joya Sandoval,Jana N Radin et al.
Caroline Vermilya et al.
Phosphate is both essential for life and toxic, necessitating the tight regulation of its acquisition. Based on Escherichia coli, most bacteria are thought to use a single accessory protein that monitors import to regulate phosphate homeost...
Turning defense into damage: HIV-driven amyloidogenesis and neurotoxicity [0.03%]
由HIV驱动的淀粉样变性及其神经毒性向损伤的转化
Feng Gu,Badeia Saed,Mojgan H Naghavi
Feng Gu
With the continued spread of human immunodeficiency virus 1 (HIV-1) and its ability to enter and persist within the central nervous system (CNS), concerns have arisen regarding its impact on cognitive health. Indeed, during the early stages...