Yanfeng Liu,Zhongyuan Liu,Xiaoqing Ou et al.
Yanfeng Liu et al.
DEAD/H-box RNA helicases are critical regulators of host antiviral innate immunity. In this study, we utilized an RNA-binding protein knockout sub-library to identify DDX46, a member of the DEAD/H-box RNA helicase family, as an essential pr...
Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication [0.03%]
SIRT1去乙酰化病毒蛋白以抑制甲型流感病毒复制
Dongdong Chen,Gejie Zhao,Jia Zhou et al.
Dongdong Chen et al.
Lactylation, a protein post-translational modification driven by lactate, plays crucial roles in various physiological and pathological processes. However, the function and underlying mechanisms of lactylation in infection and pathogenesis ...
Functional assessment of prevalent kelch13 mutations reveals high-level artemisinin resistance potential in Bangladeshi Plasmodium falciparum [0.03%]
功能性评估流行的kelch13突变发现孟加拉疟疾原虫中高水平的青蒿素抗药潜能
Maisha Khair Nima,Nirjhar Bhattacharyya,Douglas Shoue et al.
Maisha Khair Nima et al.
Artemisinin partial resistance (ART-R), driven by mutations in the Plasmodium falciparum kelch13 (k13) gene, has contributed to malaria treatment failures in the Greater Mekong Subregion (GMS). The Chittagong Hill Tracts (CHTs) of Banglades...
Increased dose of H1N1 pandemic influenza vaccine during pregnancy improves immunity in mothers and infants [0.03%]
孕期甲型H1N1流感疫苗增加剂量可改善母体和婴幼儿的免疫力
Dhvanir Kansara,Martina Kosikova,Patricia L Milletich et al.
Dhvanir Kansara et al.
Maternal-infant immunity against influenza is improved through vaccination during pregnancy. We conducted an in-depth analysis of antibody (Ab) responses in sera from pregnant and non-pregnant women immunized with an unadjuvanted inactivate...
Dissecting the homeodomain MAT locus and engineering novel tripolar and bipolar mating systems in Cryptococcus amylolentus [0.03%]
Cryptococcus amylolentus 中 HOX 基因座 MAT 的解析及新型三体和双体交配型系统的工程化改造
Liping Xiong,Vikas Yadav,Sheng Sun et al.
Liping Xiong et al.
Sex in fungi is governed by the mating-type (MAT) locus, which exists as a bipolar, pseudobipolar, or tetrapolar system. The significance and impact of MAT on sexual reproduction, however, remain understudied. Furthermore, the evolution of ...
A bacterial family of fatty acid acyltransferases related to the Shigella effector IcsB [0.03%]
与志贺氏菌效应物IcsB相关的细菌脂肪酸酰基转移酶家族
Waad Bajunaid,Kyle Tomaro,Anwer Hasil Kottarampatel et al.
Waad Bajunaid et al.
Nε-lysine-protein fatty acid acyltransferase (k-FAT) is a new class of enzyme found in bacteria that express either a MARTX toxin with a Rho-interacting domain (RID) or a type III secretion system (T3SS). The prototype k-FAT is the T3SS ef...
Suppression of Hsp90 expression in Aspergillus fumigatus enhances sensitivity to oxidative stress and activates host cell NF-κB p65 and ERK signaling pathways [0.03%]
烟曲霉Hsp90表达沉默增强了其氧化敏感性并激活宿主细胞NF-κB p65和ERK信号通路
Lingyun Song,Deqi Jiang,Xiaogang Zhou et al.
Lingyun Song et al.
This study investigates the pivotal role of the molecular chaperone Hsp90 in the growth, development, and immune modulation of the opportunistic pathogen Aspergillus fumigatus. Using a Tet-on system-based conditional expression strain, Tet-...
mGem: Facilitated fermentation-an underappreciated mode of energy conservation [0.03%]
mGem：一种被忽视的能量节约模式——代谢物促进发酵
John A Ciemniecki,Nathaniel R Glasser,Jeffrey A Gralnick et al.
John A Ciemniecki et al.
Here, we introduce a new name into the bacterial energy conservation lexicon: facilitated fermentation. This name is necessary because the more familiar terms "respiration" and "fermentation" do not adequately describe how electron balancin...
Scott B Biering,Henry Puerta-Guardo,Felix Pahmeier et al.
Scott B Biering et al.
The process by which viruses cause disease, viral pathogenesis, is the result of both infection of cells and the host immune response. A less studied but equally important contributor to viral pathogenesis is viral dissemination, the capaci...
Candida auris metabolism and growth preferences in physiologically relevant skin-like conditions [0.03%]
芽生菌代谢和生长偏好的皮肤相关生理条件
Jonathan P Nicklas,Clay Deming,ShihQueen Lee-Lin et al.
Jonathan P Nicklas et al.
Candida auris is an opportunistic, multidrug-resistant yeast with a high capacity for human skin colonization in healthcare settings, which can lead to subsequent infections with high mortality rates. Despite the recent emergence of at leas...