Live-attenuated Toxoplasma gondii RHΔ ddx6 mutant establishes comprehensive immunity against acute, chronic, and congenital toxoplasmosis [0.03%]
活减毒的-Toxoplasma gondiiRH?ddx6株诱导针对急性、隐性和先天性弓形虫病的全面免疫保护
Zhenke Yang,Jinghui Wang,Junru Wu et al.
Zhenke Yang et al.
Toxoplasma gondii is an obligate intracellular parasite causing severe disease in immunocompromised individuals and congenitally infected infants. Despite decades of research, no licensed human vaccine exists. This study evaluates a novel l...
The S32 amino acid deletion in the GP5 protein modulates the infectivity of porcine reproductive and respiratory syndrome virus [0.03%]
GP5蛋白中S32氨基酸缺失突变影响猪繁殖与呼吸综合征病毒的感染性
Xingdong Zhou,Xiaohui Zhang,Enxi Kan et al.
Xingdong Zhou et al.
The high genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant challenge to effective vaccination and infection prevention. Recently, NADC30-like PRRSV has become dominant in China. In this stu...
The Slt2-Swi6 signaling pathway plays a pivotal role in regulating cell wall biosynthesis, secondary metabolite production, and the pathogenicity of pear fungal A. alternata [0.03%]
Slt2-Swi6信号通路在梨链格孢菌细胞壁生物合成、次级代谢产物生成及致病性中发挥核心调控作用
Rong Li,Yiyang Liu,Li Li et al.
Rong Li et al.
The cell wall integrity (CWI) MAPK signal pathway is crucial for the assembly of fungal cell walls and their associated virulence, as it activates the expression of the downstream transcription factors Mbp1, Swi6 and RlmA. However, the tran...
The genotoxic stress-inducible gene GEI1(Orf19.3109) is a repressor of virulence in Candida albicans [0.03%]
钙质念珠菌中的基因毒性压力诱导型基因GEI1（Orf19.3109）是毒力的抑制因子
Yi Zhou,Wenxia Gao,Yuting Feng et al.
Yi Zhou et al.
Transcriptional reprogramming under genotoxic stress is essential for the survival and pathogenesis of Candida albicans. While many DNA damage response (DDR) genes are well-characterized, the functions of pathogen-specific, stress-inducible...
Pathogenicity and virulence of Crimean-Congo hemorrhagic fever virus: From enzootic maintenance to severe human disease [0.03%]
克里米亚-刚果出血热病毒的致病性和毒力：从地方性流行到严重人类疾病
Virginia Aida-Ficken,Teresa E Sorvillo,Elif Karaaslan et al.
Virginia Aida-Ficken et al.
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV), an enveloped, negative-sense, tri-segmented RNA virus in the genus Orthonairovirus. The virus is endemic across A...
Calycosin targets the MAPK-EGR1 signaling axis to inhibit enterovirus 71 replication in cells and human colonic organoids [0.03%]
甘草素通过靶向MAPK-EGR1信号轴抑制肠道病毒71型细胞和人结肠类器官中的复制
Yue Liu,Jiale Wang,Xin Chen et al.
Yue Liu et al.
The downstream effectors that mediate the pro‑viral function of the MAPK pathway during enterovirus 71 (EV71) infection remain poorly defined. Here we show that early growth response 1 (EGR1) is independently regulated by each of the three...
Dissecting the essential role of luxS-relevant small RNAs in biofilm formation of Streptococcus mutans [0.03%]
分析luxS相关的RNA在变异链球菌生物被膜形成中的作用
Meng-Ying Mao,Yan-Jing Liang,Ju-Xiu Chen et al.
Meng-Ying Mao et al.
Streptococcus mutans is considered the key contributor to human dental caries. The LuxS/AI-2 quorum‑sensing (QS) system in S. mutans plays a crucial role in the development of cariogenic oral biofilms. Many QS systems rely on regulation ca...
Luteolin as a urease inhibitor: A novel therapeutic strategy against Helicobacter pylori [0.03%]
作为一种尿素酶抑制剂的山柰酚：抗幽门螺旋杆菌感染的新策略研究
Xingye Wang,Dongyue Zhou,Mingran Li et al.
Xingye Wang et al.
The rising prevalence of antibiotic-resistant Helicobacter pylori (H. pylori) underscores the urgent need for alternative treatment strategies. By producing ammonia to neutralize gastric acid, the key virulence factor urease is essential fo...
D347G in PA is critical for the pathogenicity of H9N2 avian influenza A virus in mice [0.03%]
PA蛋白D347G变异是H9N2禽流感病毒致病性的关键因素
Zhehong Zhao,Ye Tian,Wenjie Jiang et al.
Zhehong Zhao et al.
Some subtypes of avian influenza A viruses (IAVs) have been associated with human infections (e.g. H3N8, H5Ny, H7Ny, H9N2, and H10Ny), and the ability of these viruses to cause zoonotic infections further increases the public health risk of...