Wei Zou,Yulong Luo,Menghua Liu et al.
Wei Zou et al.
Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons'...
Comparison of the pharmacokinetics of linezolid in burn and non-burn rabbits [0.03%]
烧伤与非烧伤兔体内利奈唑胺药代动力学比较研究
Jian-Li Ma,Lei Gao,Xiang Li et al.
Jian-Li Ma et al.
Linezolid is effective on many resistant organisms for the treatment of severe infections in burns. However, its pharmacokinetics was difficult to predict after major burns. The study aimed to describe the pharmacokinetic properties of line...
Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model [0.03%]
在兔模型中注射和口服鼠李茋的药代动力学行为研究
Khalid M Alkharfy,Ajaz Ahmad,Rao M A Khan et al.
Khalid M Alkharfy et al.
Thymoquinone (THQ), the active constituent of Nigella sativa seeds, has demonstrated some potential pharmacological activities. The present study was designed to investigate the pharmacokinetic behavior of THQ following intravenous (IV) and...
Shabnam Nazir,Zafar Iqbal,Yasar Shah et al.
Shabnam Nazir et al.
Rosuvastatin is used to treat dyslipidemia and is metabolized by CYP2C9 that shows variable metabolic activity in males and females. Pharmacokinetics (PK) of drugs varies in males and females that may result in altered drug response and the...
Pharmacokinetics of colon-specific pH and time-dependent flurbiprofen tablets [0.03%]
结肠特异性pH值和时间依赖性氟比洛芬片的药动学研究
Sateesh Kumar Vemula,Prabhakar Reddy Veerareddy,Venkat Ratnam Devadasu
Sateesh Kumar Vemula
Present research deals with the development of compression-coated flurbiprofen colon-targeted tablets to retard the drug release in the upper gastro intestinal system, but progressively release the drug in the colon. Flurbiprofen core table...
Emmanuel Bebawi,Suhail S Jouni,Andrée-Anne Tessier et al.
Emmanuel Bebawi et al.
To report a sinus bradycardia induced by metoprolol and terbinafine drug-drug interaction and its management. A 63 year-old Caucasian man on metoprolol 200 mg/day for stable coronary artery disease was prescribed a 90-day course of oral ter...
Comparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin [0.03%]
欧洲专利金丝桃叶含胡Mirabilis jalapa口服药动相互作用的比较及芸皮素与芸香素口服给药药动交互作用研究 rats
Ananth Kumar Kammalla,Mohan Kumar Ramasamy,Jyothi Chintala et al.
Ananth Kumar Kammalla et al.
Quercetin and Rutin are most common flavone constituents of some herb extracts such as Hippophae rhamnoides L. Inter and intra herb pharmacokinetics interactions of Quercetin and Rutin were investigated in the present study. Pharmacokinetic...
Pharmacokinetics of micafungin in subjects with severe hepatic dysfunction [0.03%]
米卡芬净在重度肝功能不全患者中的药代动力学
Nasrullah Undre,Benjamin Pretorius,Paul Stevenson
Nasrullah Undre
Micafungin is an echinocandin with potent activity against a broad range of fungal species, including Candida species. The pharmacokinetic and safety profiles of micafungin have been evaluated in individuals with mild-to-moderate hepatic dy...
Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats [0.03%]
木犀草素、芸香苷和紫杉醇在大鼠体内介导P-糖蛋白的药动学相互作用
K Kishore Kumar,Leena Priyanka,K Gnananath et al.
K Kishore Kumar et al.
The aim of present study was to investigate the effects of apigenin and rutin on the pharmacokinetics of paclitaxel after oral administration of paclitaxel with apigenin and rutin to rats. Paclitaxel (40 mg/kg) was administered orally alone...
Excretion of tectorigenin in rat urine orally administrated at different dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry [0.03%]
超高压液相色谱-四极杆飞行时间质谱法分析不同剂量口服给予大鼠体内金丝桃苷的尿液代谢物
Ziming Shi,Guozhe Zhang,Lizhu Zhao et al.
Ziming Shi et al.
Tectorigenin (Te) is a main active component in the flowers of Pueraria thomsonii Benth. and the rhizomes of Belamcanda chinensis (L.) DC. Previously, we have reported the pharmacokinetic properties of Te in rat plasma. The purpose of this ...