Leveraging Model-Based Simulations to Optimize Extended Dosing of Leuprolide 6-Month Intramuscular Depot Formulation [0.03%]
利用基于模型的模拟优化白蛋白结合型紫杉醇与多西他赛给药方案的研究
Li-Feng Hsu
Li-Feng Hsu
Background and objective: A gonadotropin-releasing hormone (GnRH) agonist such as leuprolide is widely used to achieve sustained suppression of testosterone levels, which play a critical role in the treatment of prostate ...
An Exploration of the Interplay Between Caffeine and Antidepressants Through the Lens of Pharmacokinetics and Pharmacodynamics [0.03%]
从药代动力学和药代动力学角度探索咖啡因与抗抑郁药的相互作用
Jenny Truong,Noor Abu-Suriya,Daniel Tory et al.
Jenny Truong et al.
Caffeine consumption is regarded as a widespread phenomenon, and its usage has continued to increase. In addition, the growing usage of antidepressants worldwide and increase in mental health disorders were shown in recent statistical analy...
Herb-Drug Interaction of Total Glucosides of Paeony and Tripterygium Glycoside with Celecoxib in Beagle Dogs by UPLC-MS/MS [0.03%]
基于UPLC-MS/MS的丹参素和雷公藤多苷与西乐葆在比格犬体内 Herb-Drug 互相作用研究
Zhifei Zhang,Huijun Wang,Xinli Ren et al.
Zhifei Zhang et al.
Background and objective: Total glucosides of paeony (TGP) capsules, tripterygium glycoside tablets (TGT), and celecoxib are commonly used drugs in clinical practice for the treatment of Rheumatoid arthritis (RA). An UPLC...
Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs [0.03%]
测定 marketed central nervous system药物的人肝微粒体内的在体外和体内内源性清除率及非结合率及人肝清除率的测定方法
Veera Raghava Chowdary Palacharla,Ramakrishna Nirogi,Nitesh Kumar et al.
Veera Raghava Chowdary Palacharla et al.
Objective: The objective of this study was to determine the apparent intrinsic clearance (Clint, app) and fraction unbound in human liver microsomes (fu, mic) of 86 marketed central nervous system (CNS) drugs and to predi...
Mass Balance Recovery, Absorption, Metabolism, and Excretion of Elinzanetant in Healthy Human Volunteers and in vitro Biotransformation [0.03%]
依拉扎内坦在健康人体中的量变恢复、吸收、代谢和排泄及体外生物转化
Simone I Schulz,Marcus-Hillert Schultze-Mosgau,Anna Engelen et al.
Simone I Schulz et al.
Background: Elinzanetant is a dual neurokinin-1,3 receptor antagonist in development for the treatment of menopausal vasomotor symptoms. The objectives of these studies were to characterize the mass balance and biotransfo...
Assessment of Piperacillin-Tazobactam Population Pharmacokinetic Models in Neonates: An External Validation [0.03%]
匹美西林-他唑巴坦新生儿群体药代动力学模型的外部验证评估
Bhim Bahadur Chaudhari,Jaya Shree Dilli Batcha,Arun Prasath Raju et al.
Bhim Bahadur Chaudhari et al.
Background and objective: Neonatal pharmacotherapy has gained attention from clinicians and regulatory agencies for optimizing the dosage of the drug which improves therapeutic outcomes in this special population. Piperac...
Pharmacokinetics of Zilurgisertib With and Without Food from Single and Multiple Ascending Dose Phase 1 Studies in Healthy Adults [0.03%]
Ⅰ期临床研究中择鲁吉西替布单剂量和多剂量空腹及餐后健康成人的药代动力学特征
Yan-Ou Yang,Xiaohua Gong,Jay Getsy et al.
Yan-Ou Yang et al.
Background and objectives: The oral, potent, and highly selective activin receptor-like kinase 2 (ALK2) inhibitor zilurgisertib (INCB000928) is in development as a treatment for fibrodysplasia ossificans progressiva (FOP)...
Evaluation of the Clinical Outcomes of Cyclosporine Short Infusion Versus Continuous Infusion Postallogenic Stem Cell Transplantation [0.03%]
环孢素短周期输注与持续输注异基因造血干细胞移植后临床疗效的评估
Shaymaa M M El-Awady,Amal M El Afifi,Rania Afifi et al.
Shaymaa M M El-Awady et al.
Background and objective: Cyclosporin A (CsA) exhibits a narrow therapeutic index and large inter-individual variation in pharmacokinetics. Two intermittent and 24-h continuous infusions (CI) are both commonly used regime...
Hypertensive Nephropathy Changes the Expression of Drug-Metabolizing Enzymes and Transporters in Spontaneously Hypertensive Rat Liver and Kidney [0.03%]
高血压肾病改变自发性高血压大鼠肝肾药物代谢酶和转运体的表达
Yueqing Pan,Zhuan Yang,Minlong Wei et al.
Yueqing Pan et al.
Background and objectives: Hypertensive nephropathy (HN) has become one of the main causes of end-stage renal disease. Drug combination therapy is a common clinical treatment for HN. However, the impact of HN on drug-meta...
Physiologically-Based Pharmacokinetic Modeling of Trofinetide in Moderate Renal Impairment for Phase 1 Clinical Study Dose Selection with Model Validation [0.03%]
生理基于药代动力学模型指导曲 forfe 轻中度肾功能不全患者一期临床试验剂量选择及模型验证
Mona Darwish,Thomas C Marbury,Rene Nunez et al.
Mona Darwish et al.
Background and objectives: Trofinetide, the first approved treatment for Rett syndrome (RTT), is primarily excreted unchanged in the urine; therefore, it is important to assess the extent to which the exposure is affected...