Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog [0.03%]
口服及静脉注射cephetamet在狗体内的药代动力学和药动学研究
Wei Wang,Xiao-Mao Zhu,Chun-Mei Wang et al.
Wei Wang et al.
The pharmacokinetic (PK) and pharmacodynamic (PD) properties of intravenously (IV) administered cefetamet-Na and per os (PO) administered cefetamet pivoxil were investigated in eighteen healthy dogs at three different dose levels. The three...
Pharmacokinetic drug-drug interaction between ethinyl estradiol and gestodene, administered as a transdermal fertility control patch, and two CYP3A4 inhibitors and a CYP3A4 substrate [0.03%]
作为经皮避孕补丁给药的炔雌醇和吉美孕素与两种CYP3A4抑制剂和一种CYP3A4底物之间的药物动力学相互作用研究
Julia Winkler,Mark Goldammer,Matthias Ludwig et al.
Julia Winkler et al.
Pharmacokinetic (PK) interactions between the cytochrome P450 3A4 (CYP3A4) pathway and transdermally administered ethinyl estradiol (EE) and gestodene (GSD) were investigated. This paper reports the findings of three open-label, intra-indiv...
The synergism mechanism of Rhubarb Anthraquinones on constipation elucidated by comparative pharmacokinetics of Rhubarb extract between normal and diseased rats [0.03%]
comparative pharmacokinetics of Rheum palmatum L. Extract in Normal and Diseased Rats to Elucidate the Synergistic Mechanism of Its Anthraquinones for Constipation Treatment
Xiao-Hong Gong,Yan Li,Ruo-Qi Zhang et al.
Xiao-Hong Gong et al.
In the study, it was hypothesized that Rhubarb Anthraquinones synergistically enhanced the purgative effect on constipation rat from the direct and indirect pathway at the same time. A validated HPLC method was successfully applied to eluci...
Cytochrome P450 isoenzymes in rat and human liver microsomes associate with the metabolism of total coumarins in Fructus Cnidii [0.03%]
香附甲基氯仿提取物中香豆素类化合物在大鼠和人肝微粒体中的代谢研究
Xiao Hu,Wei Huang,Yuan Yang
Xiao Hu
Fructus Cnidii (Cnidium) is isolated from the dry and ripe fruit of Cnidium monnier (L.) Cuss (umbelifera), an annual herb. It is demonstrated that the active constituents of Fructus Cnidii are coumarins, known as Total Coumarins of Cnidium...
Role of age-related decrease of renal organic cation transporter 2 in the effect of atenolol on renal excretion of metformin in rats [0.03%]
年龄相关肾有机阳离子转运体2下降对阿替洛尔影响 metformin 肾排泄的作用机制研究
Jiangxia Ren,Yan Zhou,Guoqiang Zhang et al.
Jiangxia Ren et al.
Many diabetes patients, especially the elder ones, suffered from hypertension simultaneously. Therefore, it is very likely that a large number of diabetes patients receiving metformin hydrochloride may simultaneously be given beta-blockers....
A comparative study on effect of metformin and metformin-conjugated nanotubes on blood glucose homeostasis in diabetic rats [0.03%]
二甲双胍和二甲双胍结合纳米管对糖尿病大鼠血糖稳态影响的比较研究
Naser Mirazi,Jamileh Shoaei,Ardeshir Khazaei et al.
Naser Mirazi et al.
Diabetes mellitus is one of the most prevalent metabolic disorders. Carbon nanotubes have the advantage to cross the plasma membrane without damaging the cells, improving the biological effect of a drug and reducing its side effects. In the...
Pharmacokinetics and toxicity of repeated oral etoposide is altered by morphine coadministration in rats [0.03%]
吗啡联合给药可改变大鼠重复口服etrposide的药代动力学和毒性
Makoto Miyazaki,Tomoko Kawase,Chisako Nishimura et al.
Makoto Miyazaki et al.
The influence of morphine (MOR) on the pharmacokinetics and toxicity of repeated etoposide (ETP) oral administration was evaluated in rats. A decrease in the number of leukocytes in blood was observed by 5 days of treatment with ETP (30 mg/...
Pharmacokinetic studies and LC-MS/MS method development of ganciclovir and dipeptide monoester prodrugs in Sprague Dawley rats [0.03%]
更昔洛韦及其二肽单酯前药在SD大鼠体内的药代动力学研究及LC-MS/MS分析方法的建立
Sriram Gunda,Ravinder Earla,Kishore Cholkar et al.
Sriram Gunda et al.
Ganciclovir (GCV) is utilized as an anti-herpetic agent. Reports from our laboratory have suggested that dipeptide ester prodrugs of GCV exhibit high affinity towards the oligopeptide transporter hPEPT1 and therefore seem to be promising ca...
Wei Zou,Yulong Luo,Menghua Liu et al.
Wei Zou et al.
Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons'...
Comparison of the pharmacokinetics of linezolid in burn and non-burn rabbits [0.03%]
烧伤与非烧伤兔体内利奈唑胺药代动力学比较研究
Jian-Li Ma,Lei Gao,Xiang Li et al.
Jian-Li Ma et al.
Linezolid is effective on many resistant organisms for the treatment of severe infections in burns. However, its pharmacokinetics was difficult to predict after major burns. The study aimed to describe the pharmacokinetic properties of line...