Preclinical assessment of Orteronel(®), a CYP17A1 enzyme inhibitor in rats [0.03%]
一种CYP17A1酶抑制剂Orteronel的药理学研究
Mohd Zainuddin,A B Vinod,Sandip Dhondiram Gurav et al.
Mohd Zainuddin et al.
Orteronel (TAK-700) is a novel and selective inhibitor of CYP17A1, which is expressed in testicular, adrenal and prostate tumor tissues. Orteronel is currently in Phase-III clinical development for metastatic castration-resistant prostate p...
Pharmacokinetics of the antiepileptic drug levetiracetam in healthy Japanese and Caucasian volunteers following intravenous administration [0.03%]
静脉给药日本受试者和白人志愿者抗癫痫药物左乙拉西胺的药动学研究
Nathalie Toublanc,Takuya Okagaki,Malcolm Boyce et al.
Nathalie Toublanc et al.
The intravenous (iv) formulation of levetiracetam has been available in clinical practice worldwide for several years, but not in Japan. Two open-label studies were conducted: Study A evaluated the bioequivalence of iv and oral tablet formu...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2015 Dec;40(4):461-9. DOI:10.1007/s13318-014-0227-4 2015
Tissue distribution and ontogeny of multidrug resistance protein 2, a phosphatidylcholine translocator, in rats [0.03%]
多药耐药性蛋白2（磷脂酰胆碱转运蛋白）在大鼠组织分布及发生学的研究
Qiuyang Zhang,Wei Yang,Hanlin Song et al.
Qiuyang Zhang et al.
Multidrug resistance protein 2 (Mdr2), encoded by ATP-binding cassette b4 (Abcb4), serves as a phospholipid flippase that is indispensable for phosphatidylcholine translocation. However, little was known about the regulation of Mdr2 in Spra...
Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs [0.03%]
单剂量静脉注射及口服R-恩索特罗和消旋 bambuterol 后的大鼠和比格犬的药代动力学及胆汁代谢物的比较研究
Su Guan,Chun-Yun Hu,Meng-Ying He et al.
Su Guan et al.
This study was to compare pharmacokinetics and bile transformation of R-enantiomer bambuterol with its racemate. Pharmacokinetics of R-enantiomer was investigated after single-dose intravenous and three doses of oral administration to rats ...
Herb-drug interaction between irinotecan and psoralidin-containing herbs [0.03%]
艾地苯与含补骨脂内酯草药的相互作用研究
Xi-Shan Zhang,Zhi-Qiang Zhao,Zhen-Sheng Qin et al.
Xi-Shan Zhang et al.
Herb-drug interaction strongly limits the clinical utilization of herbs and drugs. Irinotecan-induced diarrhea is closely related with the UDP-glucuronosyltransferase 1A1-catalyzed glucuronidation of SN-38 which has been widely regarded to ...
Tolerability and pharmacokinetics of disodium folinate following single intravenous doses in healthy Chinese subjects: an open-label, randomized, single-center study [0.03%]
二氢叶酸钠单次静脉给药在中国健康受试者中的耐受性和药代动力学：一项开放标签、随机和单中心试验
Yani Liu,Jiali Zhou,Zhongfang Li et al.
Yani Liu et al.
The tolerability and pharmacokinetics of disodium folinate may vary with different races, and these variations might result in different outcomes. This study assessed the tolerability and pharmacokinetics of disodium folinate following sing...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2015 Dec;40(4):443-51. DOI:10.1007/s13318-014-0222-9 2015
Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats [0.03%]
醋酸诺美孕素在雌性大鼠体内的药代动力学、组织分布和排泄研究
Qingbiao Huang,Xiaoke Chen,Yan Zhu et al.
Qingbiao Huang et al.
Nomegestrol acetate (NOMAC), a synthetic progestogen derived from 19-norprogesterone, is an orally active drug with a strong affinity for the progesterone receptor. NOMAC inhibits ovulation and is devoid of undesirable androgenic and estrog...
Cytochrome P450 2D6*10 genotype affects the pharmacokinetics of dimemorfan in healthy Chinese subjects [0.03%]
CYP2D6*10基因型影响.dimemorfan在健康中国受试者体内的药代动力学
Qi Pei,Jinfu Peng,Hongyi Tan et al.
Qi Pei et al.
This study aimed to investigate the effects of cytochrome P450 2D6*10 (100C > T, rs1065852) genotype on the pharmacokinetics of dimemorfan in healthy Chinese subjects. Data were evaluated from 24 subjects in two pharmacokinetic studies who ...
The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents [0.03%]
一系列穿孔素抑制剂的药代动力学作用研究作为潜在的免疫抑制剂
M R Bull,J A Spicer,K M Huttunen et al.
M R Bull et al.
The cytolytic protein perforin is a key component of the immune response and is implicated in a number of human pathologies and therapy-induced conditions. A novel series of small molecule inhibitors of perforin function have been developed...
Ocular and systemic pharmacokinetics of lidocaine hydrochloride ophthalmic gel in rabbits after topical ocular administration [0.03%]
盐酸利多卡因眼科凝胶在兔眼局部滴用后的眼部和全身药代动力学研究
Bing Liu,Li Ding,Xiaowen Xu et al.
Bing Liu et al.
Lidocaine hydrochloride ophthalmic gel is a novel ophthalmic preparation for topical ocular anesthesia. The study is aimed at evaluating the ocular and systemic pharmacokinetics of lidocaine hydrochloride 3.5 % ophthalmic gel in rabbits aft...