The optimal oral dose selection of ibandronate in Japanese patients with osteoporosis based on pharmacokinetic and pharmacodynamic properties [0.03%]
基于药动学和药效学特性的日本骨质疏松症患者伊班磷酸最佳口服剂量选择
Kiyohiko Nakai,Masato Tobinai,Junko Hashimoto et al.
Kiyohiko Nakai et al.
Ibandronate is a drug widely used outside Japan for the treatment of osteoporosis. It is available in formulations for intermittent intravenous (i.v.) administration and for intermittent (once monthly) oral administration. Ibandronate was r...
Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term [0.03%]
足月胎盘UGT1A酶表达和活性的特征及与子痫前期的关系
Abby C Collier,Audrey D Thévenon,William Goh et al.
Abby C Collier et al.
Placental UDP-glucuronosyltransferase (UGT) enzymes have critical roles in hormone, nutrient, chemical balance and fetal exposure during pregnancy. Placental UGT1A isoforms were profiled and differences between preeclamptic (PE) and non-PE ...
Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers [0.03%]
CIME药物及其代谢产物单次口服给药后的安全性及药动学(健康受试者)
Natacha Lenuzza,Xavier Duval,Grégory Nicolas et al.
Natacha Lenuzza et al.
This phase I, pilot clinical study was designed to evaluate the safety and the pharmacokinetic (PK) profiles of the CIME (Metabolic Identity Card) combination of ten drugs, with a view to its use as a phenotyping cocktail. Ten healthy Cauca...
CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers [0.03%]
CYP3A5*3和MDR1 C3435T是国产鲁帕替丁在中国健康志愿者中的药代动力学个体差异的影响因素
Yuqing Xiong,Zhao Yuan,Jingzhi Yang et al.
Yuqing Xiong et al.
Rupatadine (RUP) is an oral antihistamine and platelet-activating factor antagonist and is shown as the substrate of CYP3A5 and P-gp. The significant interindividual differences of CYP3A5 and P-gp often cause bioavailability differences of ...
Inhibitory action of Epilobium hirsutum extract and its constituent ellagic acid on drug-metabolizing enzymes [0.03%]
Epilobium hirsutum提取物及其成分 Ellagic酸对药物代谢酶的抑制作用
Gurbet Celik,Aslı Semiz,Serdar Karakurt et al.
Gurbet Celik et al.
Epilobium hirsutum (EH) is a medicinal plant for treating various diseases. Despite its wide usage, there is no available information about its potential influences on drug metabolism. The present study was undertaken to determine the in vi...
In vitro metabolism of bencycloquidium bromide and its inhibitory effects on human P450 isoenzymes: implication of CYP2D6, CYP2C19 and CYP3A4/5 [0.03%]
溴代苯并奎啶体在体外的代谢及对人P450同工酶抑制作用：涉及CYP2D6、CYP2C19和CYP3A4/5
Janvier Engelbert Agbokponto,Lingling Zhang,Linlin Hu et al.
Janvier Engelbert Agbokponto et al.
Bencycloquidium bromide (BCQB) is a novel selective muscarinic M1/M3 receptor antagonist with potent therapeutic effects on rhinitis and chronic obstructive pulmonary disease. The metabolism of BCQB has been investigated in human liver micr...
John Wilton,Elena Kurenova,Laura Pitzonka et al.
John Wilton et al.
Inhibition of focal adhesion kinase-vascular endothelial growth factor receptor 3 complex by C4 was previously shown to reduce tumor growth alone and synergistically with other chemotherapeutic agents in animal tumor models. Single and mult...
CYP3A4-based drug-drug interaction: CYP3A4 substrates' pharmacokinetic properties and ketoconazole dose regimen effect [0.03%]
基于CYP3A4药物相互作用的研究:CYP3A4底物的药动学特性及酮康唑给药方案的影响
Xavier Boulenc,Olivier Nicolas,Stéphanie Hermabessière et al.
Xavier Boulenc et al.
The aim of the study was to assess the magnitude of the CYP3A4 inhibitory effect of 2 dosing regimens of ketoconazole and the influence of the pharmacokinetic properties of the CYP3A4 substrate on the extent of the substrate exposure increa...
Evaluation of physicochemical properties and intestinal permeability of six dietary polyphenols in human intestinal colon adenocarcinoma Caco-2 cells [0.03%]
六种饮食多酚的理化性质及人结肠腺癌Caco-2细胞肠道通透性评价
Himanshu Rastogi,Snehasis Jana
Himanshu Rastogi
Phenolic compounds are common ingredients in many dietary supplements and functional foods. However, data concerning physicochemical properties and permeability of polyphenols on the intestinal epithelial cells are scarce. The aims of this ...
Metabolic pathway profiling of the derivative of important herbal component noscapine [0.03%]
重要中药成分Noscapine衍生物的代谢路径分析
Yonghua Yao,Yang Xiong
Yonghua Yao
The present study aims to investigate the influence of metabolic behavior by the introduction of bromo atom into the structure of noscapine. Oral gavage of 50 mg/kg bromo-noscapine for 6- to 8-week-old male mice with C57BL/6 background resu...