The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5 [0.03%]
乌索林对OATP1B1*1a和*5介导的罗苏伐他汀摄取的影响
Wen Jin Hua,Wei Xiao Hua,Fu Yong Nan et al.
Wen Jin Hua et al.
Chinese herbal medicines such as hawthorn, salvia, etc., are frequently combined with statins so as to treat cardiovascular diseases more effectively. Chinese herbal medicines contain many kinds of active components, which may have drug-dru...
The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers [0.03%]
丹诺瑞欣（GSK1325756）普通和生物增强型片剂口服给药在健康老年人受试者中的药代动力学研究
Bruce E Miller,Kevin Smart,Sunil Mistry et al.
Bruce E Miller et al.
Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. The objective of the study was to evaluate the relative bioavailability, incl...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2014 Sep;39(3):173-81. DOI:10.1007/s13318-014-0179-8 2014
Functional characterization of cynomolgus monkey UDP-glucuronosyltransferase 1A9 [0.03%]
食蟹猴UDP-葡萄糖醛酸转移酶1A9的功能表征
Kohei Yamamoto,Marina Mukai,Kenjiro Nagaoka et al.
Kohei Yamamoto et al.
UDP-glucuronosyltransferase 1A9 (UGT1A9) contributes to the glucuronidation of numerous drugs. Cynomolgus monkeys are regarded as experimental animals similar to humans in studies on safety evaluation and biotransformation for drug developm...
Preparation and in vitro/in vivo evaluation of felodipine nanosuspension [0.03%]
非洛地平纳米混悬剂的制备及体内外评价研究
Bhanu P Sahu,Malay K Das
Bhanu P Sahu
The purpose of this study was to develop a nanosuspension of a poorly soluble drug felodipine by nanoprecipitation to achieve superior in vitro dissolution and high oral absorption in vivo in rats. Felodipine nanosuspensions were prepared b...
Solid dispersion tablets of breviscapine with polyvinylpyrrolidone K30 for improved dissolution and bioavailability to commercial breviscapine tablets in beagle dogs [0.03%]
盐酸 Breviscapine与聚乙烯吡咯烷酮K30固态溶液的制备及其在比格犬中的药动学研究
Wenjuan Cong,Lan Shen,Desheng Xu et al.
Wenjuan Cong et al.
Breviscapine, one of cardiovascular drugs extracted from a Chinese herb Erigeron breviscapinus, has been frequently used to treat cardiovascular diseases such as hypertension, angina pectoris, coronary heart disease and stroke. However, its...
Influence of hepatic impairment on the pharmacokinetics of the dopamine agonist rotigotine [0.03%]
肝功能损害对多巴胺激动剂罗替戈汀药代动力学的影响
Willi Cawello,Andreas Fichtner,Hilmar Boekens et al.
Willi Cawello et al.
The transdermally applied dopamine receptor agonist rotigotine is extensively metabolized in the liver. An open-label, parallel-group study was conducted to evaluate the effects of moderate hepatic impairment on the pharmacokinetics, safety...
Controlled Clinical Trial
European journal of drug metabolism and pharmacokinetics. 2014 Sep;39(3):155-63. DOI:10.1007/s13318-013-0153-x 2014
Changes in the expression levels of tight junction components during reconstruction of tight junction from mucosal lesion by intestinal ischemia/reperfusion [0.03%]
肠缺血再灌注粘膜损伤修复过程中紧密连接的重建及其表达水平变化研究
Yusuke Takizawa,Hisanao Kishimoto,Mikio Tomita et al.
Yusuke Takizawa et al.
Tight junction (TJ) is composed of the most apical components of the intercellular junctional complex in epithelial cells; TJ has cell polarity and functions as a major determinant of epithelial barrier function. In this study, to clarify t...
The study of absorption kinetics of berberine based on portal vein in rat, and the influence of verapamil and borneol to its absorption ability by UHPLC method [0.03%]
高效液相法研究小檗碱经门静脉吸收动力学及其穿膜吸收能力受维拉帕米和冰片的影响
Liang Zou,Rui Li,Ping Wang et al.
Liang Zou et al.
This paper aims to investigate the portal-vein absorption kinetics of berberine in rat, and the influence of P-gp inhibitors such as verapamil and borneol, to its absorption ability. In the paper, a validated UHPLC method was established to...
Concurrent administration of atypical antipsychotics and donepezil: drug interaction study in rats [0.03%]
非典型抗精神病药与多奈哌齐联合应用的药物相互作用研究（大鼠模型）
Ramakrishna Nirogi,Gopinadh Bhyrapuneni,Vishwottam Kandikere et al.
Ramakrishna Nirogi et al.
Psychotic and behavioral symptoms are common in patients with dementia. Thus, it is rational to assume that patients with dementia would gain benefit from combination therapy of an antipsychotic agent and a cognitive enhancer. Antipsychotic...