Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice [0.03%]
小鼠静脉注射LXY药动学的生理基础模型研究
Elżbieta Wyska,Artur Świerczek,Krzysztof Pociecha et al.
Elżbieta Wyska et al.
Lisofylline (LSF), is the R-(-) enantiomer of the metabolite M1 of pentoxifylline, and is currently under development for the treatment of type 1 diabetes. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) m...
Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation [0.03%]
他克莫司联合霉酚酸钠在肾移植术后一年内的药动学研究
Joanna Sobiak,Matylda Resztak,Maciej Głyda et al.
Joanna Sobiak et al.
We assessed the relations between MPA, free MPA (fMPA) and MPA glucuronide (MPAG) pharmacokinetics and the clinical condition of renal transplant recipients treated with EC-MPS and tacrolimus (Tac) in the first post-transplant year. In 18 a...
Sunitinib tissue distribution changes after coadministration with ketoconazole in mice [0.03%]
卡托普利对小鼠体内索坦分布行为的影响研究
Evelyn Li-Ching Chee,Adeline Yi Ling Lim,Pilar Modamio et al.
Evelyn Li-Ching Chee et al.
Sunitinib is a multitargeted tyrosine kinase inhibitor approved for gastrointestinal stromal tumor (GIST), advanced renal cell carcinoma (RCC) and pancreatic neuroendocrine tumors. It is metabolized via CYP3A4 and has low brain penetration ...
Effects of dose, flow rate, and bile acid on diclofenac disposition in the perfused rat liver [0.03%]
剂量、流速和胆酸对大鼠肝脏灌流模型中diclofenac处置的影响
Misato Uraki,Atsushi Kawase,Yuka Matsushima et al.
Misato Uraki et al.
An in situ perfused rat liver system is useful for studying the hepatic disposition of drugs and their metabolites. However, the effects of the perfusion conditions on drug disposition are unclear. We examined the effects of conditions such...
Preparation, characterization and pharmacokinetics evaluation of clarithromycin-loaded Eudragit(®) L-100 microspheres [0.03%]
克拉霉素载药Eudragit(®)L-100微球的制备、表征及药动学评价
Jinghua Xu,Wei Li,Zhuo Liu et al.
Jinghua Xu et al.
The aim of this work was to prepare pH-dependent clarithromycin microsphere formulation by emulsion solvent evaporation method, employing Eudragit(®) L-100. Prepared microspheres were evaluated by carrying out in vitro release and in vivo ...
Absorption, elimination and cerebrospinal fluid concentrations of nimodipine in healthy beagle dogs receiving human intravenous and oral formulation [0.03%]
健康小猎犬静脉注射和口服尼莫地平后的药代动力学及脑脊液浓度研究
Janne Koskimäki,Miikka Tarkia,Tuula Ahtola-Sätilä et al.
Janne Koskimäki et al.
Nimodipine is an L-type calcium channel blocker and is used to treat vasospasm in patients with subarachnoid hemorrhage. Its putative mechanism of action is relaxation of smooth muscle cells in cerebral arteries. In addition, nimodipine may...
The CYP4502D6 *4 and *6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients [0.03%]
CYP4502D6*4和*6等位基因是药物反应的分子遗传标志：在Collisin无反应FMF患者中的应用意义
Sinem Yalcıntepe,Ozturk Ozdemır,Coskun Sılan et al.
Sinem Yalcıntepe et al.
The cytochrome P450 2D6 (CYP2D6) is a cytochrome P450 enzyme involved in the oxidative biotransformation of the xenobiotics, carcinogens and various clinically important drugs. Patients are evaluated in three sub-groups of extensive (EM), i...
Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach [0.03%]
基于人群的贝叶斯方法建立人体对乙酰氨基酚及其主要代谢产物药代动力学的生理模型
Todd J Zurlinden,Brad Reisfeld
Todd J Zurlinden
The principal aim of this study was to develop, validate, and demonstrate a physiologically based pharmacokinetic (PBPK) model to predict and characterize the absorption, distribution, metabolism, and excretion of acetaminophen (APAP) in hu...
Comparison of pharmacokinetic and safety profiles between Bemfola(®) and Gonal-f(®) after subcutaneous application [0.03%]
贝美芬纳与果隆芬纳皮下给药后的药代动力学及安全性比较
Michael Wolzt,Ghazeleh Gouya,Michael Sator et al.
Michael Wolzt et al.
Recombinant human follicle stimulating hormone (r-hFSH) is effective and safe for controlled ovarian stimulation. Bemfola(®) (Finox AG, Burgdorf, Switzerland), a new biosimilar r-hFSH, has proven comparable non-clinical pharmacological pro...
Efflux and uptake transporters involved in the disposition of bazedoxifene [0.03%]
参与拜泽他昔芬体内处置的外排和摄取转运体
Tina Trdan Lušin,Aleš Mrhar,Bruno Stieger et al.
Tina Trdan Lušin et al.
Bazedoxifene, a novel selective estrogen receptor modulator, has complex pharmacokinetics with rapid absorption, high metabolic clearance, low oral bioavailability (6.25 %) and a slow elimination phase. Our hypothesis is that drug uptake an...