Evidence of reduced oral bioavailability of paracetamol in rats following multiple ingestion of grapefruit juice [0.03%]
证据表明柑橘汁多次摄入后会降低扑热息痛在大鼠体内的口服生物利用度
Nidal A Qinna,Obbei A Ismail,Tawfiq M Alhussainy et al.
Nidal A Qinna et al.
The aim of the current investigation was to assess the ability GFJ to modulate the pharmacokinetic profile of paracetamol following single or repeated administrations of GFJ in Sprague-Dawley rats. Diclofenac and carbamazepine were both use...
Pharmacokinetic and biodistribution study of eserine and pralidoxime chloride in rabbits following a single application of a transdermal patch [0.03%]
经皮给药后毛果芸香碱和氯化碘解磷定在兔体内的药代动力学及组织分布研究
Subham Banerjee,Pronobesh Chattopadhyay,Animesh Ghosh et al.
Subham Banerjee et al.
In the present study, a simple reverse-phase high-performance liquid chromatography method with diode array detection has been developed and validated for the simultaneous determination and quantification of eserine and pralidoxime chloride...
A novel injection strategy of flurbiprofen axetil by inhibiting protein binding with 6-methoxy-2-naphthylacetic acid [0.03%]
一种通过抑制蛋白质结合用6-甲氧基-2-萘乙酸注射氟比洛芬醋酯的新方法
Kenji Ogata,Norito Takamura,Jin Tokunaga et al.
Kenji Ogata et al.
Flurbiprofen axetil (FPA) is an injection product and a prodrug of a non-steroidal anti-inflammatory drug (NSAID). After injection, it is rapidly hydrolyzed to the active form, flurbiprofen (FP). Since frequent injections of FPA can lead to...
Hua-Jun Qu,Yang Qian
Hua-Jun Qu
Amino-noscapine is a promising noscapine derivative undergoing R&D as an efficient anti-tumor drug. In vitro phase I metabolism incubation system was employed. In vitro samples were analyzed using ultra-performance liquid chromatography cou...
Evaluation of clinical bradycardiac effect and respiratory adverse effect of β-blocking agents in coronary computed tomography angiography based on theoretical analysis [0.03%]
基于理论分析的冠状动脉CT造影β受体阻滞剂慢心率效应和呼吸不良反应评价研究
Kaori Fujito,Risa Takayanagi,Koji Kimura et al.
Kaori Fujito et al.
β-blocking agents are used for patients with tachycardia to improve the image quality of coronary computed tomography angiography (CCTA). In this study, we analyzed the clinical bradycardiac effects and the adverse respiratory effects of f...
Initial dosing regimen of vancomycin to achieve early therapeutic plasma concentration in critically ill patients with MRSA infection based on APACHE II score [0.03%]
基于APACHE II评分的危重症MRSA感染患者静脉给药万古霉素以期早期达到治疗血浆浓度的初始剂量方案研究
Masaharu Imaura,Haruko Yokoyama,Yuji Kohata et al.
Masaharu Imaura et al.
It is essential to assure the efficacy of antimicrobials at the initial phase of therapy. However, increasing the volume of distribution (Vd) of hydrophilic antimicrobials in critically ill patients leads to reduced antimicrobial concentrat...
Frequencies of UGT1A4*2 (P24T) and *3 (L48V) and their effects on serum concentrations of lamotrigine [0.03%]
UGT1A4*2(P24T)和*3(L48V)等位基因的频率及其对拉莫三嗪血药浓度的影响
Arne Reimers,Wenche Sjursen,Grethe Helde et al.
Arne Reimers et al.
The gene encoding uridine diphosphate glucuronosyltransferase (UGT) 1A4 shows considerable polymorphism. Several common drugs are metabolised by UGT1A4, among them lamotrigine (LTG). Experimental and clinical studies suggest that certain va...
The role of CYP2C9 genetic polymorphism in carvedilol O-desmethylation in vitro [0.03%]
细胞色素P450 2C9基因多态性对卡维地洛O-脱甲基化的作用：体外研究
Pei-Pei Pan,Qing-Hua Weng,Chen-Jian Zhou et al.
Pei-Pei Pan et al.
We aimed at investigating the role of CYP2C9 in carvedilol O-desmethylation and identifying the effect of 35 CYP2C9 allelic variants we found in Chinese Han population on the in vitro metabolism of carvedilol. Recombinant CYP2C9 and CYP2D6 ...
The optimal oral dose selection of ibandronate in Japanese patients with osteoporosis based on pharmacokinetic and pharmacodynamic properties [0.03%]
基于药动学和药效学特性的日本骨质疏松症患者伊班磷酸最佳口服剂量选择
Kiyohiko Nakai,Masato Tobinai,Junko Hashimoto et al.
Kiyohiko Nakai et al.
Ibandronate is a drug widely used outside Japan for the treatment of osteoporosis. It is available in formulations for intermittent intravenous (i.v.) administration and for intermittent (once monthly) oral administration. Ibandronate was r...
Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term [0.03%]
足月胎盘UGT1A酶表达和活性的特征及与子痫前期的关系
Abby C Collier,Audrey D Thévenon,William Goh et al.
Abby C Collier et al.
Placental UDP-glucuronosyltransferase (UGT) enzymes have critical roles in hormone, nutrient, chemical balance and fetal exposure during pregnancy. Placental UGT1A isoforms were profiled and differences between preeclamptic (PE) and non-PE ...