Prediction of the pharmacokinetics and tissue distribution of levofloxacin in humans based on an extrapolated PBPK model [0.03%]
基于外推的生理药动学模型预测左氧氟沙星在人体内的药动学及组织分布特征
Liqin Zhu,Yuan Zhang,Jianwei Yang et al.
Liqin Zhu et al.
This study developed a physiologically based pharmacokinetic (PBPK) model in intraabdominally infected rats and extrapolated it to humans to predict the levofloxacin pharmacokinetics and penetration into tissues. Twelve male rats with intra...
Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking [0.03%]
分子对接研究CYPIAI酶代谢帕唑帕尼的行为预测
Xing-Jie Liu,Hua Lu,Ju-Xiang Sun et al.
Xing-Jie Liu et al.
Metabolism-mediated drug adverse effects (e.g., drug-drug interaction, bioactivation, etc.) strongly limit the utilization of clinical drugs. The present study aims to predict the metabolic capability of cytochrome P450 (CYP) 3A4 toward paz...
Michaelis-Menten elimination kinetics of etanercept, rheumatoid arthritis biologics, after intravenous and subcutaneous administration in rats [0.03%]
rats中静脉和皮下给药后依那西普的米氏动力学清除研究
Byung-Yo Lee,Kwang-Il Kwon,Min-Soo Kim et al.
Byung-Yo Lee et al.
Etanercept was approved by the Food and Drug Administration (FDA) in 2010 as a biologic agent for the treatment of rheumatoid arthritis (RA). The aim of the study was to investigate the pharmacokinetic properties of etanercept after intrave...
Pomegranate juice does not affect the disposition of simvastatin in healthy subjects [0.03%]
健康受试者中石榴汁不影响辛伐他汀的药代动力学性质
Soo-Jin Park,Chang-Woo Yeo,Eon-Jeong Shim et al.
Soo-Jin Park et al.
Previous in vitro and in vivo investigations reported controversial results for the inhibitory potential of pomegranate on Cytochrome P450 (CYP) 3A activity. This study evaluated the effect of pomegranate juice on the disposition of simvast...
Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice [0.03%]
高胆固醇饮食对大鼠和小鼠Niemann-Pick C1-like 1及肠道转运蛋白表达水平的影响
Atsushi Kawase,Yasuha Araki,Yukiko Ueda et al.
Atsushi Kawase et al.
Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 are all involved in intestinal cholesterol absorption. It is unclear whether a high-cholesterol (HC) diet affects the expression of these transporters in rats and mice...
Population pharmacokinetic modeling of oxcarbazepine active metabolite in Chinese patients with epilepsy [0.03%]
中国癫痫患者奥卡西平活性代谢物的人群药代动力学模型研究
Yunli Yu,Quanying Zhang,Wenjun Xu et al.
Yunli Yu et al.
The aim of the study was to develop a population pharmacokinetic (PPK) model of oxcarbazepine and optimize the treatment of oxcarbazepine in Chinese patients with epilepsy. A total of 108 oxcarbazepine therapeutic drug monitoring samples fr...
A study on the PK and BA profiles in the mouse body for leonurine O/O microemulsion with determination by the LC-MS/MS method [0.03%]
基于LC-MS/MS测定的耳缘静脉滴注欧李黄酮素油悬剂的小鼠药动学研究
Yanan Sun,Xiang Zhang,Tao Lu et al.
Yanan Sun et al.
Leonurine (LE) has been found to have therapeutic efficacy in cerebral thrombosis, but its poor solubility in water leads to very low bioavailability. In this article, a leonurine O/O microemulsion (LE-ME) was prepared and investigated for ...
Preparation, characterization and in vitro/vivo evaluation of tectorigenin solid dispersion with improved dissolution and bioavailability [0.03%]
一种具有良好溶解性和生物利用度的毛蕊异黄素固体分散体制备、表征及体内外评价研究
Shuping Shuai,Shanlan Yue,Qingting Huang et al.
Shuping Shuai et al.
The purpose of this study was to develop and evaluate a novel amorphous solid dispersion system for tectorigenin (TG). TG is one of isoflavone aglycones extracted from Iris tectorum and flowers of Pueraria thunbergiana, but its poor water s...
Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice [0.03%]
小鼠静脉注射LXY药动学的生理基础模型研究
Elżbieta Wyska,Artur Świerczek,Krzysztof Pociecha et al.
Elżbieta Wyska et al.
Lisofylline (LSF), is the R-(-) enantiomer of the metabolite M1 of pentoxifylline, and is currently under development for the treatment of type 1 diabetes. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) m...
Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation [0.03%]
他克莫司联合霉酚酸钠在肾移植术后一年内的药动学研究
Joanna Sobiak,Matylda Resztak,Maciej Głyda et al.
Joanna Sobiak et al.
We assessed the relations between MPA, free MPA (fMPA) and MPA glucuronide (MPAG) pharmacokinetics and the clinical condition of renal transplant recipients treated with EC-MPS and tacrolimus (Tac) in the first post-transplant year. In 18 a...