Drug-Drug Interactions of a Novel κ-Opioid Receptor Agonist, Nalfurafine Hydrochloride, Involving the P-Glycoprotein [0.03%]
新型κ受体激动剂纳曲酮盐酸盐与P-糖蛋白相互作用的研究
Akihiro Ando,Shinichiro Sasago,Yoshihiro Ohzone et al.
Akihiro Ando et al.
Background and objective: Nalfurafine hydrochloride (TRK-820), which exhibits strong κ-opioid agonistic activity, has an antipruritic effect on uremic pruritus. The permeability of nalfurafine across human P-glycoprotein...
Yan Zhao,Guosheng Tang,Qiang Tang et al.
Yan Zhao et al.
α-Mangostin, a major xanthone isolated from the pericarp of Garcinia mangostana, exhibits anti-inflammatory and antitumor effects. Its absolute bioavailability is low, with minimal oral absorption. In this article, a soft capsule, with veg...
A UPLC-MS Method for Simultaneous Determination of Geniposidic Acid, Two Lignans and Phenolics in Rat Plasma and its Application to Pharmacokinetic Studies of Eucommia ulmoides Extract in Rats [0.03%]
基于UPLC-MS同时测定大鼠血浆中梓醇、两种木脂素和酚类成分的含量及其在大鼠体内杜仲提取物药代动力学研究中的应用
Yongjun Li,Zipeng Gong,Xu Cao et al.
Yongjun Li et al.
The bark of Eucommia ulmoides is a well-known Chinese herbal medicine that is used to regulate blood pressure and reduce blood sugar and fats, as well as an antioxidant and antimicrobial agent. Here we describe the development of a sensitiv...
The Pharmacokinetics and Tissue Distribution of Honokiol and its Metabolites in Rats [0.03%]
honokiol及其代谢产物在大鼠体内的药代动力学和组织分布研究
Wang Jun-Jun,Miao Xiao-Lei,Chen Jing-Ya et al.
Wang Jun-Jun et al.
Honokiol (HK) is the main bioactive compound isolated from the bark of Magnolia officinalis. The present work is the first to report the pharmacokinetics and distribution of HK and its two metabolites of hydroxylated HK conjugated with gluc...
Trizel du Toit,Maides M Malan,Hendrik J R Lemmer et al.
Trizel du Toit et al.
Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study investigated binary combination...
Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2'-methylguanosine-5'-monophosphate, in the monkey and formulation optimization for human exposure [0.03%]
IDX184的药代动力学研究及其在恒河猴中的肝脏靶向递送和剂量优化研究报告：2'-甲基鸟苷-5'-单磷酸口服前药
Xin-Ru Pan-Zhou,Benjamin A Mayes,Hassan Rashidzadeh et al.
Xin-Ru Pan-Zhou et al.
IDX184 is a phosphoramidate prodrug of 2'-methylguanosine-5'-monophosphate, developed to treat patients infected with hepatitis C virus. A mass balance study of radiolabeled IDX184 and pharmacokinetic studies of IDX184 in portal vein-cannul...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2016 Oct;41(5):567-74. DOI:10.1007/s13318-015-0267-4 2016
Population Pharmacokinetics and Pharmacodynamics of Piperacillin/Tazobactam in Patients with Nosocomial Infections [0.03%]
哌拉西林他唑巴坦治疗医院感染患者的群体药代动力学和药效学研究
Rong Chen,Qing Qian,Meng-Ru Sun et al.
Rong Chen et al.
Objective: The study was to establish a population pharmacokinetic (PPK) model of piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to propose optimized dosage regimens in patients with ...
Gender-Related Differences in the Expression of Organic Cation Transporter 2 and its Role in Urinary Excretion of Metformin in Rats [0.03%]
有机阳离子转运体2的性别差异表达及其对 rats中降糖药二甲双胍排泄的影响研究
Yan-Rong Ma,Hong-Yan Qin,Yong-Wen Jin et al.
Yan-Rong Ma et al.
Organic cation transporter 2 (rOCT2) and multidrug and toxin extrusion protein 1 (rMATE1) are mainly expressed in rat renal proximal tubules and mediate urinary excretion of cationic drugs, such as metformin. Accumulated evidence indicated ...
Pharmacokinetics, Pharmacodynamics, and Tolerability of Single and Multiple Doses of Trandolapril, an Effective Angiotensin-Converting Enzyme Inhibitor, in Healthy Chinese Subjects [0.03%]
特拉普利在健康中国受试者中的药代动力学、药效学和耐受性：单次给药与多次给药研究
Xiaojiao Li,Chang Liu,Min Wu et al.
Xiaojiao Li et al.
Trandolapril is the pro-drug of trandolaprilat, a non-sulfhydryl angiotensin-converting enzyme inhibitor. This study was designed to assess the pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of single and multiple doses of t...
Yichuan Zhang,Jin Li,Xiaolin Lei et al.
Yichuan Zhang et al.
The aim of this study was to investigate the role of P-glycoprotein (P-gp) in the intestinal absorption of triptolide. In this research, the bidirectional transport of triptolide across Caco-2 cells was studied in vitro. Moreover, the pharm...