Microbial Metabolism of Atovaquone and Cytotoxicity of the Produced Phase I Metabolite [0.03%]
克拉维酸增强多黏菌素B抗菌活性的机制研究
Eliane de Oliveira Silva,Natália Dos Santos Gonçalves,Raquel Alves Dos Santos et al.
Eliane de Oliveira Silva et al.
Background and objectives: Atovaquone is a hydroxynaphthoquinone with selective action in the mitochondrial respiratory chain of malaria parasite. It is employed for both the treatment and prevention of malaria, in a comb...
Population Pharmacokinetic Analysis of the Oral Absorption Process and Explaining Intra-Subject Variability in Plasma Exposures of Imatinib in Healthy Volunteers [0.03%]
伊马替尼口服吸收过程的人群药代动力学分析及受试者间和受试者内变异性研究
Ali-Akbar Golabchifar,Saeed Rezaee,Nahid Mobarghei Dinan et al.
Ali-Akbar Golabchifar et al.
Background and objective: Imatinib mesylate is presently the first-line treatment for chronic myeloid leukemia (CML). The aim of this study was to investigate the absorption and distribution kinetics of imatinib in health...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2016 Oct;41(5):527-39. DOI:10.1007/s13318-015-0292-3 2016
Chronopharmacokinetics of Erlotinib and Circadian Rhythms of Related Metabolic Enzymes in Lewis Tumor-Bearing Mice [0.03%]
埃洛替尼的 chronopharmacokinetics 及对小鼠Lewis肿瘤相关代谢酶生物钟节律的影响
Jiao Liu,Chun-Yan Wang,Song-Gang Ji et al.
Jiao Liu et al.
Objective: The purpose of the current study was to investigate the effect of the dosing time on the pharmacokinetics of erlotinib and the circadian rhythms of the metabolism enzymes in tumor-bearing mice. ...
Formulation and Pharmacokinetic Evaluation of Polymeric Dispersions Containing Valsartan [0.03%]
缬沙坦聚维酮固体分散体的处方筛选及其药动学研究
Naveen Chella,Bhaskar Daravath,Dinesh Kumar et al.
Naveen Chella et al.
Background: Valsartan exhibits poor aqueous solubility and dissolution rate limited absorption. The lower solubility in the upper part of gastrointestinal tract (pH-dependant solubility) where its absorption window exists...
Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability [0.03%]
细胞色素P450 2B6（CYP2B6）基因多态性c.516G>T（rs3745274）对丙泊酚剂量变异性的影晌
Artemísia L Mourão,Fabiana G de Abreu,Marilu Fiegenbaum
Artemísia L Mourão
Background and objectives: Propofol is the most commonly used hypnotic worldwide, but its effective dose varies greatly between individuals. The present study sought to investigate the relationship between the c.516G>T po...
Impact of Menopause on Pharmacokinetics of Rosuvastatin Compared with Premenopausal Women [0.03%]
绝经对 rosuvastatin 药代动力学的影响与未绝经女性的比较研究
Shabnam Nazir,Zafar Iqbal,Fazli Nasir
Shabnam Nazir
Background and objective: Rosuvastatin is used to treat dyslipidemia and its use is quite frequent among postmenopausal women. Menopause significantly affects the pharmacokinetics of drugs, and altered drug response and t...
Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway [0.03%]
突尼斯类风湿关节炎患者甲氨蝶呤毒性的基因决定因素：涉及MTX代谢途径多态性的研究
Souhir Chaabane,Sameh Marzouk,Rim Akrout et al.
Souhir Chaabane et al.
Background and objective: Methotrexate (MTX) is a disease-modifying anti-rheumatic drug used in the treatment of rheumatoid arthritis (RA). It is the first line drug in the treatment of this disease. However, MTX-related ...
Metabolic Profile of Isocorynoxeine in Rats Obtained by Ultra-High Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry [0.03%]
基于UHPLC-Q-TOF/MS的异京尼平在大鼠体内的代谢产物鉴定
Lizhu Zhao,Wen Qi,Fangfang Chen et al.
Lizhu Zhao et al.
Background and objective: Isocorynoxeine (IC), a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems. Its metabolic pathway, however, h...
Drug-Drug Interactions of a Novel κ-Opioid Receptor Agonist, Nalfurafine Hydrochloride, Involving the P-Glycoprotein [0.03%]
新型κ受体激动剂纳曲酮盐酸盐与P-糖蛋白相互作用的研究
Akihiro Ando,Shinichiro Sasago,Yoshihiro Ohzone et al.
Akihiro Ando et al.
Background and objective: Nalfurafine hydrochloride (TRK-820), which exhibits strong κ-opioid agonistic activity, has an antipruritic effect on uremic pruritus. The permeability of nalfurafine across human P-glycoprotein...
Yan Zhao,Guosheng Tang,Qiang Tang et al.
Yan Zhao et al.
α-Mangostin, a major xanthone isolated from the pericarp of Garcinia mangostana, exhibits anti-inflammatory and antitumor effects. Its absolute bioavailability is low, with minimal oral absorption. In this article, a soft capsule, with veg...