A Phase I Study to Evaluate the Relative Bioavailability, Pharmacodynamics, and Safety of a Single Subcutaneous Injection of Recaticimab at Three Different Sites in Healthy Chinese Subjects [0.03%]
一项在健康中国受试者中评估Recaticimab单次皮下注射给药三个不同部位后的相对生物利用度、药效学和安全性的I期研究
Ying Wang,Yuanzhi Cheng,Yuhan Guo et al.
Ying Wang et al.
Background and objectives: Recaticimab (SHR-1209) is a humanized monoclonal antibody that binds to the proprotein convertase subtilisin/kexin type 9 (PCSK9) with high affinity. This study was conducted to compare the rela...
Pharmacokinetic/Pharmacodynamic Modeling of the Acute Heart Rate Effects of Delta-9 Tetrahydrocannabinol and Its Major Metabolites After Intravenous Injection in Healthy Volunteers [0.03%]
大麻酚和主要代谢产物对健康志愿者静脉注射后急性心率影响的药代动力学/药效学模型研究
W R Wolowich,R Greif,L Theiler et al.
W R Wolowich et al.
Background and objectives: Cannabis consumption is increasing in both the recreational and medical settings. Tetrahydrocannabinol (THC) is known to produce cardiovascular effects, but the specific roles of THC and its met...
Influence of Polymorphisms in Pharmacokinetics-Related Genes on the Areas Under the Plasma Concentration-Time Curves of Doxorubicin and Doxorubicinol in Patients with Diffuse Large B-Cell Lymphoma Receiving CHOP Therapy [0.03%]
药动学相关基因多态性对CHOP方案治疗弥漫大B细胞淋巴瘤患者阿霉素及其代谢产物阿霉索林血药浓度曲线下面积的影响
Keigo Saito,Takenori Takahata,Junichi Nakagawa et al.
Keigo Saito et al.
Background and objectives: Doxorubicin (DOX) and its metabolite doxorubicinol (DOXol) are drugs with large differences in pharmacokinetics (PK) between patients. In this study, we investigated the effects of polymorphisms...
Minimal Physiologically-Based Pharmacokinetic Modeling of Atenolol and Metoprolol Absorption in Malnourished Rats [0.03%]
应用于营养不良大鼠阿替洛尔和美托洛尔吸收的最小生理药代动力学模型研究
Fatma Kir,Selma Sahin,William J Jusko
Fatma Kir
Background and objective: The pharmacokinetics of drugs can be altered by pathophysiological changes in the body that result from malnutrition. The objective of this study was to evaluate the profiles derived from in vivo...
In Vitro and In Vivo Pharmacokinetic Characterization of 7-Hydroxymitragynine, an Active Metabolite of Mitragynine, in Sprague-Dawley Rats [0.03%]
7-羟基醉麻藤碱的体内外药代动力学特征（在Sprague-Dawley大鼠中的研究）
Yi-Hua Chiang,Siva Rama Raju Kanumuri,Michelle A Kuntz et al.
Yi-Hua Chiang et al.
Background and objectives: Kratom, a Southeast Asian tree, has been researched for its potential as a therapeutic for substance use disorders. The most abundant alkaloid in kratom, mitragynine, is being investigated indiv...
Development of a Physiologically-Based Pharmacokinetic Model for Quantitative Interpretation of Transdermal Drug Delivery of Rotigotine, a Dopamine Agonist for Treating Parkinson's Disease [0.03%]
罗替戈汀的生理药代动力学模型的发展，用于定量解释经皮给药过程。作为一种多巴胺激动剂，罗替戈汀可用于治疗帕金森病。
Ji-Hun Jang,Seung-Hyun Jeong
Ji-Hun Jang
Background and objective: Rotigotine, a dopamine agonist, is used to treat Parkinson's disease and restless leg syndrome, with transdermal patches being the primary delivery method in clinical practice. However, quantitat...
Effect of Gastric pH on the Pharmacokinetics of Atorvastatin and its Metabolites in Healthy Participants [0.03%]
胃内pH值对健康受试者中阿托伐他汀及其代谢产物的药代动力学的影响
Bridget Louise Morse,Xiaosu Ma,Rong Liu et al.
Bridget Louise Morse et al.
Background and objective: Atorvastatin is dosed in its active acid form although it exists in equilibrium with its inactive lactone form in vivo. Although in vitro atorvastatin acid displays pH-dependent conversion to the...
Luigi La Via,Andrea Marino,Giuseppe Cuttone et al.
Luigi La Via et al.
The clinical pharmacology of antiretroviral therapy (ART) in critical care presents unique challenges due to the complex interplay between HIV infection, critical illness, and drug management. This comprehensive review examines the pharmaco...
Correction: Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs [0.03%]
校正：测定上市中枢神经系统药物的人肝微粒体固有清除率和非结合率及体外-体内推算肝清除率
Veera Raghava Chowdary Palacharla,Ramakrishna Nirogi,Nitesh Kumar et al.
Veera Raghava Chowdary Palacharla et al.
Dosage Recommendations for Off-label Use of Mycophenolate Mofetil in Pediatric Patients with Thalassemia Undergoing Hematopoietic Stem Cell Transplantation: An Approach Based on Population Pharmacokinetic Studies [0.03%]
基于人群药代动力学研究的地中海贫血患者行造血干细胞移植后使用吗替麦考酚酯治疗的用药推荐剂量
Lu-Lu Niu,Yong-Jun Liu,Yun Wu et al.
Lu-Lu Niu et al.
Background and objectives: As an immunosuppressant, mycophenolate mofetil (MMF) is used to prevent graft versus host disease (GVHD) in patients after hematopoietic stem cell transplantation (HCT). This study aimed to esta...