Physiologically-Based Pharmacokinetic Modeling of Trofinetide in Moderate Renal Impairment for Phase 1 Clinical Study Dose Selection with Model Validation [0.03%]
生理基于药代动力学模型指导曲 forfe 轻中度肾功能不全患者一期临床试验剂量选择及模型验证
Mona Darwish,Thomas C Marbury,Rene Nunez et al.
Mona Darwish et al.
Background and objectives: Trofinetide, the first approved treatment for Rett syndrome (RTT), is primarily excreted unchanged in the urine; therefore, it is important to assess the extent to which the exposure is affected...
The Loss-of-Function ATP Binding Cassette Subfamily G Member 2 Polymorphism ABCG2 c.421C>A Reduces Lamotrigine Trough Concentrations in Adults with Epilepsy [0.03%]
ABCG2失活多态性位点c.421C>A通过降低拉莫三嗪谷浓度影响癫痫患者的治疗效力
Nada Božina,Iva Klarica Domjanović,Ivana Šušak Sporiš et al.
Nada Božina et al.
Background and objectives: The commonly used antiseizure medication lamotrigine is a substrate to ATP binding cassette subfamily G member 2 (ABCG2) transporter. The objective of this study was to evaluate the effect of th...
Assessment of Abuse Liability and Nicotine Pharmacokinetics of glo Heated Tobacco Products in a Randomized, Crossover Study [0.03%]
一项随机交叉研究评估了英美烟草公司glo加热烟草产品的滥用潜力和尼古丁药代动力学属性
Milly N Kanobe,Patrudu Makena,Kristen Prevette et al.
Milly N Kanobe et al.
Background and objective: Heated tobacco products (HTPs) are a class of non-combustible, inhaled tobacco products with the potential to reduce the harm associated with cigarette smoking due to reduced cigarette smoke toxi...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2024 Nov;49(6):733-750. DOI:10.1007/s13318-024-00921-4 2024
Comparison of Vancomycin AUC24 Calculation Methods for Neonates and Infants [0.03%]
新生儿和婴儿万古霉素AUC24计算方法的比较
Tuomas Laitila,Ulla Sankilampi,Marjo Renko et al.
Tuomas Laitila et al.
Background and objective: For neonates and infants receiving intermittent vancomycin infusions, the area under the concentration-time curve during 24 h (AUC24) is often estimated with Bayesian forecasting using one or mor...
Novel Fimasartan Fluidized Solid Dispersion and Its Tablet: Preparation, Crystallinity, Solubility, Dissolution, and Pharmacokinetics in Beagle Dogs [0.03%]
伐洛沙坦固态分散体及其片剂的制备、结晶性、溶解度、溶出度和比格犬药代动力学研究
Dong Chul Shin,Jung Hyun Cho,Fakhar Ud Din et al.
Dong Chul Shin et al.
Background and objectives: Fimasartan, an angiotensin II receptor antagonist, exhibits low bioavailability due to its poor solubility; consequently, using solubilization technologies is essential to improve its bioavailab...
Pharmacokinetic Model of Drug Interaction of Tacrolimus with Combined Administration of CYP3A4 Inhibitors Voriconazole and Clarithromycin After Bone Marrow Transplantation [0.03%]
异基因骨髓移植后氟康唑与克拉霉素联用对他克莫司药代动力学影响的体外-体内相关模型研究
Toshinori Hirai,Takahiko Aoyama,Yasuhiro Tsuji et al.
Toshinori Hirai et al.
Background and objectives: A pharmacokinetic model has been developed to quantify the drug-drug interactions of tacrolimus with concentration-dependent inhibition of cytochrome P450 (CYP) 3A4 from voriconazole and clarith...
Pharmacokinetic and Pharmacodynamic Interaction of Finerenone with Diltiazem, Fluconazole, and Ritonavir in Rats [0.03%]
finerenone与维拉帕米、氟康唑和利托那韦在大鼠体内的药代动力学和药效学相互作用
Tham Thi Bui,So-Hyeon Kim,Woojin Jung et al.
Tham Thi Bui et al.
Background and objectives: Finerenone, a novel selective non-steroidal mineralocorticoid receptor antagonist, has been indicated in chronic kidney disease associated with type 2 diabetes mellitus. Considering the potentia...
Prediction of First-in-Human Dose of Chimeric Antigen Receptor-T (CAR-T) Cells from Mice [0.03%]
基于小鼠模型预测 CAR-T 细胞首次人体试验剂量
Iftekhar Mahmood
Iftekhar Mahmood
BACKGROUND AND OBJECTIVE: Currently, there is no available method for the prediction of first-in-human (FIH) dose for chimeric antigen receptor-T (CAR-T) cells. The objective of this work was to predict the FIH dose of CAR-T cells from diff...
Vancomycin in Pediatric Patients with Cystic Fibrosis: Dose Optimization Using Population Pharmacokinetic Approach [0.03%]
万古霉素在囊性纤维化患儿中剂量优化的群体药代动力学研究
Aysenur Yaliniz,Mathieu Blouin,Marie-Élaine Métras et al.
Aysenur Yaliniz et al.
Background: An increase in Staphylococcus aureus infections has been reported in pediatric patients with cystic fibrosis (CF) over the last few years. This pathogen is commonly treated with vancomycin, an antibiotic for w...
Whole Body Physiologically Based Pharmacokinetic Model to Explain A Patient With Drug-Drug Interaction Between Voriconazole and Flucloxacillin [0.03%]
用于解释伏立康唑与氟氯西林药物相互作用的患者全身生理药动学模型
Heshu Abdullah-Koolmees,Julia F van den Nieuwendijk,Simone M K Ten Hoope et al.
Heshu Abdullah-Koolmees et al.
Background and objectives: Voriconazole administered concomitantly with flucloxacillin may result in subtherapeutic plasma concentrations as shown in a patient with Staphylococcus aureus sepsis and a probable pulmonary as...