Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling [0.03%]
基于稀疏的真实世界数据和PBPK建模定义MSSA感染CNS的安全有效头孢唑林给药 regimen
Samuel Dubinsky,Mark McIntyre,Min-Soo Kim et al.
Samuel Dubinsky et al.
Background and objective: Infections in the central nervous system (CNS) are serious and carry a significant risk of morbidity and mortality. Though commonly used as prophylaxis for neurosurgical interventions, cefazolin ...
Bioequivalence and Comparative Pharmacokinetics of Two Generic Mirogabalin Besylate Tablets (5 mg and 10 mg) and Tarlige® in Healthy Chinese Volunteers: A Pooled Analysis of Two Randomized, Open-Label, Two-Period Crossover Studies [0.03%]
两种米诺福林 besylate 智服林片仿制药（5毫克和10毫克）与参比制剂在中国健康志愿者中的生物等效性及比较药代动力学研究：两项随机、开放标签、两周期交叉试验的汇总分析
Fengling Wang,Haitao Yu,Xi Ye et al.
Fengling Wang et al.
Background and objective: Mirogabalin besylate is a selective α2δ-1 ligand approved for diabetic peripheral neuropathic pain. This study evaluated the pharmacokinetic (PK) bioequivalence and safety of generic 5 mg and 1...
Stability of Colistin Active Forms in Biological Matrices: Effect of Temperature and Time [0.03%]
多粘菌素活性形式在生物基质中的稳定性：温度和时间的影响
Vendula Kubíčková,Jitka Rychlíčková,Karel Urbánek et al.
Vendula Kubíčková et al.
Background: This study investigated the effects of temperature and concentration on the short-term stability of colistin and colistin methanesulphonate in three biological matrices; whole blood, plasma and serum. ...
A Validated LC-MS/MS Method for Unbound Rifapentine Quantitation Reveals Nonlinear Plasma Protein Binding and Comparable Free Fractions Between Adults and Children with Tuberculosis [0.03%]
一种经验证的LC-MS/MS方法用于未结合利福平定量，揭示了成人和儿童结核病患者中血浆蛋白非线性结合及游离分数相当
Wenmei Qiao,Mutong Fang,Miaona Liu et al.
Wenmei Qiao et al.
Background and objective: Therapeutic drug monitoring (TDM) typically uses total drug concentration (Ct), but pharmacological effects depend on free concentration (Cf), especially for highly protein-bound drugs like rifap...
Minimal Physiologically-Based Pharmacokinetic Modeling to Predict Concentration-Time Profiles of Poorly Soluble Cinacalcet Hydrochloride in Fasting and Fed State [0.03%]
预测空腹和餐后状态下难溶性氢氯噻嗪浓度-时间曲线的最小生理药代动力学模型
Xiaoqian Xie,Le Sun
Xiaoqian Xie
Background and objective: Obtaining pharmacokinetic curves is crucial for drug dosage selection, and for assessment of efficacy and adverse effects in clinical practice. The aim of this study was to utilize a minimal phys...
Sex-Specific Differences in Rat Renal CYP Enzyme Expression and Activity Following Isoproterenol-Induced Injury [0.03%]
异丙肾上腺素诱发损伤后大鼠肾CYP酶表达及活性的性别差异研究
Sara A Helal,Samar H Gerges,Ayman O S El-Kadi
Sara A Helal
Background and objective: The expression and activity of cytochrome P450 (CYP) enzymes are influenced by sex differences, and their arachidonic acid (AA)-mediated metabolites play crucial roles in physiological and pathol...
A Phase 1, Open-Label, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ES-481 After Oral Administration in Healthy Volunteers [0.03%]
一项在健康受试者中评估口服ES-481单次递增剂量后药代动力学、安全性和耐受性的I期开放标签临床研究
Robert Niecestro,Emma C Foster,Lyn Millist et al.
Robert Niecestro et al.
Background and objectives: ES-481 is a potent and selective antagonist of the transmembrane alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptor regulatory protein (TARP)-y8-dependent AMPA receptor bei...
Dose Optimization of Piperacillin for Pseudomonas aeruginosa Infection in Febrile Neutropenic Pediatric Patients [0.03%]
发热性中性粒细胞减少症儿科患者的铜绿假单胞菌感染哌拉西林剂量优化研究
Chanon Supapon,Sirima Sitaruno,Sutthiporn Pattharachayakul et al.
Chanon Supapon et al.
Background: Febrile neutropenic pediatric oncology patients require aggressive antimicrobial therapy against Pseudomonas aeruginosa, but standard piperacillin dosing may provide suboptimal exposure due to altered pharmaco...
The Influence of CBD and THC on Hepatic Enzymes of the Human Cytochrome P450 Complex Family: A Systematic Literature Review [0.03%]
大麻二酚和四氢大麻酚对人细胞色素P450复合物家族肝酶影响的系统文献回顾
Mariana Candeias Dos Santos,Anderson Matheus Pereira da Silva,Maria da Vitória Santos do Nascimento et al.
Mariana Candeias Dos Santos et al.
Background and objective: Phytocannabinoids, the main bioactive compounds of Cannabis sativa, are metabolized by hepatic cytochrome P450 (CYP450) enzymes and can also modulate their function. Since CYP450 isoforms are res...
From Interaction to Intervention: Intentional CYP Inhibition as a Scalable Strategy to Expand Access to High-Cost Therapies [0.03%]
从相互作用到干预：有意的CYP抑制作为扩大高成本药物获取范围的可扩展策略
Fernando De la Garza Salazar
Fernando De la Garza Salazar
Intentional cytochrome P450 (CYP) inhibition has been proposed as a pharmacoeconomic strategy capable of reducing oncology drug costs (33-90%) while maintaining clinical efficacy. While the pharmacokinetic effects of CYP inhibition have lon...