Understanding Pulmonary and Systemic Pharmacokinetics of Inhaled Fluticasone Propionate in Healthy Subjects Using Population PK Analysis [0.03%]
利用群体药代动力学分析方法研究健康志愿者吸入丙酸氟替卡松后的肺部和全身药代动力学特征
Juliet Rebello,Sharvari Shukla,KRaghu Naidu et al.
Juliet Rebello et al.
Background and objectives: One of the main hurdles in pulmonary drug delivery is the inability to directly quantify drug concentrations at the site of action within the lungs, which are critical for therapeutic efficacy. ...
Structure Elucidation and Initial Characterization of a N-glucuronide Metabolite (M1) of Tuvusertib [0.03%]
Tuvusertib 葡糖醛酸代谢产物 M1 的结构解析及初步特征分析
Benedikt Lang,Hanno Schieferstein,Kai Thede et al.
Benedikt Lang et al.
Background and objective: The investigational DNA-damage response inhibitor tuvusertib showed the formation of a direct glucuronide in hepatocyte incubations. Early metabolite identification workflows were unable to assig...
Determinants and Machine Learning Prediction of Subtherapeutic Sodium Valproate Concentrations in Epilepsy Management in Xinjiang, China [0.03%]
中国新疆地区癫痫治疗中亚临床钠 valproate 血药浓度的影响因素及预测模型研究
Hao Yang,Xue Lv,Akbar Kadeer et al.
Hao Yang et al.
Background and objective: Valproic acid is a classic antiepileptic drug; however, it is characterized by a narrow therapeutic window, limited safety margin, and marked individual variability. Therapeutic drug monitoring h...
Pharmacokinetics, Safety, and Tolerability of Obeldesivir in Healthy Japanese and White Participants [0.03%]
奥贝替拉西在健康日本受试者和白人受试者中的药代动力学、安全性和耐受性
Chi-Chi Peng,Eric Salgado,Jessica Corpus et al.
Chi-Chi Peng et al.
Background and objective: Obeldesivir is an orally administered prodrug of the nucleoside GS-441524. In vitro and preclinical studies have shown that obeldesivir can inhibit severe acute respiratory syndrome coronavirus 2...
Kinetics of Sevoflurane Vaporized Directly in Extracorporeal Membrane Oxygenators-Ex Vivo Findings and Pharmacokinetic/Pharmacodynamic Simulations [0.03%]
直接在外膜氧合器中蒸发的七氟烷的动力学：体外研究和药代动力学/药效学模拟
Diana Morales Castro,Mark Alm,Federico Carlos Carini et al.
Diana Morales Castro et al.
Background: Although sedation is commonly used in patients undergoing venovenous extracorporeal membrane oxygenation (V-V ECMO), the use of volatile anesthetics is less frequent, and there is limited data on the pharmacok...
Estimation of Plasma Meropenem Concentrations in Patients with Severe Infections Using Ultraviolet and Visible Range Spectrophotometry: A Pilot Study [0.03%]
使用紫外及可见光谱吸光法估算严重感染患者血浆美罗培南浓度的试点研究
Paul Skorup,Fredrik Sjövall,Fredrik Huss et al.
Paul Skorup et al.
Background and objective: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-l...
Evaluating Oxaliplatin Exposure in Adults with Advanced Colorectal Cancer: Development and Validation of Methods with Enhanced Bioanalytical Specificity and Clinical Applicability [0.03%]
评估成人晚期结直肠癌患者中奥沙利铂暴露情况：开发和验证具有增强生物分析特异性和临床适用性的方法
John Ho,Catherine Han,Mark James McKeage
John Ho
Background and aims: The clinical efficacy and adverse effects of oxaliplatin [Pt(DACH)(oxalato)] (DACH = 1R,2R-cyclohexanediamine) may depend upon systemic drug exposure quantified as the area under the plasma concentrat...
Population Pharmacokinetics of Melphalan in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation with Various Conditioning Regimens [0.03%]
采用不同预处理方案行自体造血干细胞移植的儿童马法兰群体药代动力学分析
Jung Yoon Choi,Byungwook Kim,Hyun Jin Park et al.
Jung Yoon Choi et al.
Background and objective: Melphalan is an alkylating agent used in conditioning regimens for hematopoietic stem cell transplantation (HSCT) in pediatric patients. In this study, we aimed to develop a population pharmacoki...
Personalizing Liposomal Paclitaxel in Platinum-Based Combination Therapy for Gynecologic Cancers: Defining a Therapeutic Window Based on Tc>0.05 and CYP2C8 Metabolic Capacity [0.03%]
基于Tc>0.05和CYP2C8代谢能力的铂类联合疗法中个性化脂质体多西他赛治疗妇科肿瘤的剂量窗口研究
Shuai Jiang,Yao Yao,Dongqing Gao et al.
Shuai Jiang et al.
Background and objective: Current body surface area (BSA)-based dosing of liposomal paclitaxel (L-PTX) fails to account for substantial interpatient variability in drug exposure, leading to inconsistent therapeutic outcom...
Limited Sampling Strategies to Estimate the Exposition of Different Lipid Nanocaspules [0.03%]
有限取样策略估计不同脂质纳米胶囊暴露量的方法
Jean-Luc Cissé,Samuel Legeay,Vincent Lebreton
Jean-Luc Cissé
Background and objective: The use of nanoparticles in the field of drug delivery and the optimization of pharmacokinetic profiles in vivo is a growing area of research. The aim of this study is to determine the key sampli...