Novel Techniques and Models for Studying the Role of the Gut Microbiota in Drug Metabolism [0.03%]
研究肠道微生物在药物代谢中的作用的新技术和模型
Jianling Tan,Bingxuan Fu,Xiaojie Zhao et al.
Jianling Tan et al.
The gut microbiota, known as the second human genome, plays a vital role in modulating drug metabolism, significantly impacting therapeutic outcomes and adverse effects. Emerging research has elucidated that the microbiota mediates a range ...
Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers [0.03%]
微剂量探针药物在健康志愿者中评价羟氯喹对细胞色素P450（CYP）3A和CYP2D6活性的影响
Felicitas Stoll,Antje Blank,Gerd Mikus et al.
Felicitas Stoll et al.
Background and objective: Although polypharmacy is a particular challenge in daily rheumatological practice, clinical research on the effects of hydroxychloroquine (HCQ), a commonly used drug for patients with rheumatic d...
Randomized Controlled Trial
European journal of drug metabolism and pharmacokinetics. 2024 Jan;49(1):101-109. DOI:10.1007/s13318-023-00872-2 2024
Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats [0.03%]
大黄蒽醌类化合物在正常及非酒精性脂肪肝模型大鼠体内的药动学比较研究
Fang Zhang,Rui Wu,Yanfang Liu et al.
Fang Zhang et al.
Background and objectives: Rhubarb anthraquinones contain five main components, that is, rhein, emodin, aloe-emodin, chrysophanol, and physcion, which demonstrate good therapeutic effects on nonalcoholic fatty liver disea...
Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration [0.03%]
一种新型 tramadol 双层缓释片剂（含速释组分）的开发、理化特性及药代动力学研究
Naoki Ishitsubo,Shinji Oguro,Hirotoshi Shimahashi et al.
Naoki Ishitsubo et al.
Background and objective: There are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased adherence to immediate-release (IR) formulations due to the high number of ...
Mass Balance and Metabolic Pathways of Eliapixant, a P2X3 Receptor Antagonist, in Healthy Male Volunteers [0.03%]
P2X3受体拮抗剂eliapixant在健康男性中的质量平衡和代谢途径研究
Stefanie Reif,Marcus-Hillert Schultze-Mosgau,Anna Engelen et al.
Stefanie Reif et al.
Background: Overactive adenosine triphosphate signaling via P2X3 homotrimeric receptors is implicated in multiple conditions. To fully understand the metabolism and elimination pathways of eliapixant, a study was conducte...
Anastasiia Kalinina,Elena Grigorieva,Anna Smirnova et al.
Anastasiia Kalinina et al.
Background and objective: Cyclophilin A (CypA) is an isomerase that functions as a chaperone, housekeeping protein, and cyclosporine A (CsA) ligand. Secreted CypA is a proinflammatory factor, chemoattractant, immune regul...
Pharmacokinetics of Imatinib Mesylate and Development of Limited Sampling Strategies for Estimating the Area under the Concentration-Time Curve of Imatinib Mesylate in Palestinian Patients with Chronic Myeloid Leukemia [0.03%]
伊马替尼的药代动力学及建立估计慢性粒细胞白血病患者体内伊马替尼浓度-时间曲线下面积的抽样策略
Deema Hilmi Adawi,Nadia Ben Fredj,Ahmad Al-Barghouthi et al.
Deema Hilmi Adawi et al.
Background and objective: Imatinib is a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML). The area under the concentration-time curve (AUC) is a pharmacokinetic parameter that symbolizes o...
Pharmacokinetics of 4-Hydroxybenzaldehyde in Normal and Cerebral Ischemia-Reperfusion Injury Rats Based on Microdialysis Technique [0.03%]
微透析技术评价4-羟基苯甲醛在正常和脑缺血再灌注损伤大鼠体内的药动学行为研究
Chunping Xu,Jin Feng,Hang Sun et al.
Chunping Xu et al.
Aim: 4-Hydroxybenzaldehyde (4-HBd) is used for the treatment of headaches, dizziness, and convulsions. The objective of this study was to characterize the pharmacokinetics of 4-HBd in cerebral ischemia-reperfusion injury ...
Ticagrelor Steady-State Trough Concentration in Chinese Patients Undergoing Percutaneous Coronary Intervention [0.03%]
替卡格雷在经皮冠状动脉介入治疗患者中的稳态谷浓度（中国人群中）
ShaoJun Zheng,Qiong Jie,NaiDong Chen et al.
ShaoJun Zheng et al.
BACKGROUND AND OBJECTIVE: Platelets play a pivotal role in thrombotic events associated with acute coronary syndrome (ACS), making oral antiplatelet therapy a cornerstone in antithrombotic strategies. The dosing regimen for the oral antipla...
Distribution, Metabolism, and Excretion of Cenobamate in Adult, Fetal, Neonatal, and Lactating Rats [0.03%]
成人、胎儿、新生儿及泌乳大鼠体内托匹司他的分布、代谢和排泄研究
Jairam Palamanda,Kelli J Glenn,Susan M Melnick
Jairam Palamanda
Background and objective: Cenobamate is an antiseizure medication (ASM) approved for treatment of focal epilepsy in adults. The objective of this study was to characterize the distribution, metabolism, and excretion of ce...