Pharmacokinetic Study of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles HY-088 in Rats [0.03%]
超小型超顺磁性氧化铁纳米颗粒HY-088在大鼠体内药代动力学研究
Xin Song,Minglan Zheng,Heping Hu et al.
Xin Song et al.
Background and objective: HY-088 injection is an ultrasmall superparamagnetic iron oxide nanoparticle (USPIOs) composed of iron oxide crystals coated with polyacrylic acid (PAA) on the surface. The purpose of this study w...
Pharmacokinetics, Safety Profile, and Tolerability of Tetramethylpyrazine Nitrone Tablets After Single and Multiple Ascending Doses in Healthy Chinese Volunteers [0.03%]
单次和多次递增剂量四甲基吡嗪硝酮片在健康中国志愿者中的药代动力学、安全性和耐受性研究
Gangzhi Zhu,Liu Wang,Shaojin Zhong et al.
Gangzhi Zhu et al.
Background and objectives: Tetramethylpyrazine nitrone (TBN) is a novel tetramethylpyrazine derivative armed with a strong free radical scavenging nitrone moiety. This study aims to evaluate the pharmacokinetics, safety p...
Pharmacokinetics of Dasatinib in Rats: a Potential Food-Drug Interaction with Naringenin [0.03%]
Dasatinib在大鼠体内的药代动力学：与柚皮素可能发生食物-药物相互作用
Mohammad Raish,Ajaz Ahmad,Badr Abdul Karim et al.
Mohammad Raish et al.
Background and objectives: The novel tyrosine kinase inhibitor (TKI) dasatinib, a multitarget inhibitor of Bcr-Abl and Src family kinases, has been licensed for the treatment of Ph+ acute lymphoblastic leukemia and chroni...
Pharmacokinetic-Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate [0.03%]
血友病A中的药动学-药效学建模：给药VWF /FVIII浓缩液后将凝血酶和纤溶酶的生成与FVIII活性关联起来
Lars L F G Valke,Michael E Cloesmeijer,Hassan Mansouritorghabeh et al.
Lars L F G Valke et al.
Background: Hemophilia A patients are treated with factor (F) VIII prophylactically to prevent bleeding. In general, dosage and frequency are based on pharmacokinetic measurements. Ideally, an alternative dose adjustment ...
Influence of Bile Acids on Clindamycin Hydrochloride Skin Permeability: In Vitro and In Silico Preliminary Study [0.03%]
胆酸对克林霉素氯化物皮肤渗透性的影响：体外和计算机模拟初步研究
Dragana Zaklan,Dušan Nešić,Darko Mitrović et al.
Dragana Zaklan et al.
Background and objective: Topical clindamycin formulations are widely used in clinical practice, but poor bioavailability and restricted skin penetration considerably limit their therapeutic efficacy. Penetration enhancem...
Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges [0.03%]
优化静脉注射药物使用者的抗生素治疗：叙事综述揭示药动学/药效学挑战
Marta Colaneri,Camilla Genovese,Pietro Valsecchi et al.
Marta Colaneri et al.
Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). While the standard antibiotic dosing strategies for speci...
Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Ocedurenone (KBP-5074) in Individuals with Moderate Hepatic Impairment [0.03%]
新型非甾体类矿物皮质激素受体拮抗剂Ocedurenone（KBP-5074）在中度肝功能障碍个体中的药代动力学研究
James McCabe,Jay Zhang,Fred Yang et al.
James McCabe et al.
Background and objectives: Ocedurenone (KBP-5074) is a novel nonsteroidal mineralocorticoid receptor antagonist that has demonstrated safety and efficacy in clinical trials in patients with uncontrolled hypertension and s...
Improved Pharmacokinetic and Pharmacodynamic Profile of Deuterium-Reinforced Tricyclic Antidepressants Doxepin, Dosulepin, and Clomipramine in Animal Models [0.03%]
氘强化的三环抗抑郁药多塞平、都硫毗嗪和氯米帕明在动物模型中的改进药物代谢动力学和药物效应动力学特性
Shreyash Moharir,Likhit Akotkar,Urmila Aswar et al.
Shreyash Moharir et al.
Background and objectives: Doxepin, dosulepin, and clomipramine are tricyclic antidepressants (TCAs) that act as serotonin and noradrenaline reuptake inhibitors. The metabolites formed by N-dealkylation of these tricyclic...
Naling Fan,Liying Du,Teng Guo et al.
Naling Fan et al.
Background and objective: Imatinib is primarily transported into the liver by organic cation transporter 1 (OCT1), organic anion transporting polypeptide 1B3 (OATP1B3), and novel organic cation transporter 2 (OCTN2), whic...
Pharmacokinetics of Long-Acting Methylphenidate: Formulation Differences, Bioequivalence, Interchangeability [0.03%]
长效右旋苯丙胺的药代动力学：剂型差异、生物等效性及可互换性
Mostafa Moharram,Tony Kiang
Mostafa Moharram
BACKGROUND AND OBJECTIVE: Attention deficit hyperactivity disorder is one of the most common neuropsychiatric conditions in children, and methylphenidate (MPH) is one of the first-line therapies. MPH is available in a variety of extended-re...