Does Age Influence Immunosuppressant Drug Pharmacokinetics in Kidney Transplant Recipients? [0.03%]
年龄会影响肾移植受者的免疫抑制剂药代动力学吗？
Amelia R Cossart,Nicole M Isbel,Scott B Campbell et al.
Amelia R Cossart et al.
Background: The pharmacokinetics of immunosuppressant drugs may change with advancing age, potentially affecting patient outcomes. Objective: ...
Pharmacokinetics and Bioavailability Study of a Novel Smoothened Inhibitor TPB15 for Treatment of Triple-Negative Breast Cancer in Rats by High Performance Liquid Chromatography-Mass Spectrometry [0.03%]
高效液相色谱-质谱法测定TPB15在大鼠体内的药代动力学及生物利用度研究
Bo-Yu Chen,Jia-Huan Xu,Qian-Qing Chen et al.
Bo-Yu Chen et al.
Background and objectives: Smoothened (SMO), a key component of the hedgehog signaling pathway, represents a therapeutic target for triple negative breast cancer (TNBC), yet the chemotherapy response rate in TNBC patients...
Precision Medicine Strategies to Improve Isoniazid Therapy in Patients with Tuberculosis [0.03%]
提高异烟肼治疗肺结核患者疗效的精准医疗策略
Levin Thomas,Arun Prasath Raju,Surulivelrajan Mallayasamy et al.
Levin Thomas et al.
Due to interindividual variability in drug metabolism and pharmacokinetics, traditional isoniazid fixed-dose regimens may lead to suboptimal or toxic isoniazid concentrations in the plasma of patients with tuberculosis, contributing to adve...
The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug-Drug Interactions [0.03%]
质子泵抑制剂合并给药对CDK4/6抑制剂大鼠药代动力学的影响：肝脏及转运体介导的药物相互作用评估的意义
Prajakta Harish Patil,Mrunal Desai,Sumit Birangal et al.
Prajakta Harish Patil et al.
Background and objectives: Numerous clinical concerns have been expressed regarding the potential worsening of cyclin-dependent kinase 4/6 inhibitor effects in breast cancer patients because of co-administration of proton...
Drug Interactions between Traditional Chinese Medicines and Cardiovascular Drugs [0.03%]
中草药与心血管药物相互作用研究
Qi Shen,Wenxuan Chen,Wei Wang et al.
Qi Shen et al.
Cardiovascular disease (CVD) is one of the leading causes of death worldwide, and its internal medicine treatments are mostly single/few-target chemical drugs. Long-term use of cardiovascular drugs for complex chronic diseases may lead to s...
In Vitro Ciclopirox Glucuronidation in Liver Microsomes from Humans and Various Experimental Animals [0.03%]
人及其他实验动物肝微粒体中的环吡肟葡萄糖醛酸化 In vitro 研究
Wenjing Li,Yufan Xue,Feng Zhang et al.
Wenjing Li et al.
Background and objective: Ciclopirox is a widely used antifungal drug, redisposition of which has drawn increasing attentions due to multiple promising activities. The drug undergoes extensive glucuronidation, which acts ...
The ATP-Binding Cassette Transporter-Mediated Efflux Transport of Ganciclovir at the Blood-Brain Barrier [0.03%]
更昔洛韦通过血脑屏障的ATP结合盒转运多药耐药机制研究
Yuheng Shan,Yuying Cen,Xiaojiao Xu et al.
Yuheng Shan et al.
Background and objective: Recent studies have highlighted the key role of the ATP-binding cassette (ABC) transporters, including the P-glycoprotein (P-gp), the breast cancer resistance protein (BCRP), and the multi-drug r...
The Competitive Counterflow Assay for Identifying Drugs Transported by Solute Carriers: Principle, Applications, Challenges/Limits, and Perspectives [0.03%]
竞争性逆流法鉴定溶质载体转运药物：原理、应用、挑战/限制及前景
Olivier Fardel,Amélie Moreau,Jennifer Carteret et al.
Olivier Fardel et al.
The identification of substrates for solute carriers (SLCs) handling drugs is an important challenge, owing to the major implication of these plasma membrane transporters in pharmacokinetics and drug-drug interactions. In this context, the ...
External Evaluation of Population Pharmacokinetic Models of Piperacillin in Preterm and Term Patients from Neonatal Intensive Care [0.03%]
早产和足月新生儿重症监护病房患者哌拉西林人群药代动力学模型的外部评价
Frida S Boer-Pérez,Victoria Lima-Rogel,Ana R Mejía-Elizondo et al.
Frida S Boer-Pérez et al.
Background and objectives: Piperacillin/tazobactam is extensively used off-label to treat late-onset neonatal sepsis, but safety and pharmacokinetic data in this population are limited. Additionally, the organic immaturit...
Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes [0.03%]
两种碳酸酐酶抑制剂对主要细胞色素P450酶活性的抑制作用
Fawzy A Elbarbry,Tamer M Ibrahim,Mohamed A Abdelrahman et al.
Fawzy A Elbarbry et al.
Background and objectives: Both AW-9A (coumarin derivative) and WES-1 (sulfonamide derivative) were designed and synthesized as potential selective carbonic anhydrase inhibitors and were tested for anticancer activity. Th...