La découverte de l’insuline 1921–1922 : un saut dans la recherche biomédicale [0.03%]
胰岛素的发现：1921-1922——生物医学研究中的一个飞跃
William Rostène
William Rostène
Discovery of insulin. If the symptoms of diabetes have been known since Antiquity, it is at the end of the 19th century that several investigators searched for the active substance of the pancreas and endeavoured to produce extracts that lo...
Erratum : Dégradation induite des protéines par des molécules PROTAC et stratégies apparentées : développements à visée thérapeutique - Biologie Aujourd’hui 215 (1-2), 25-43 (2021) https://doi.org/10.1051/jbio/2021007 [0.03%]
PROTAC分子及其类似物诱导蛋白质降解的机制及潜在治疗策略——生物退化第215卷(1-2), 25-43页(2021) doi:10.1051/jbio/2021007Erratum
Michèle Reboud-Ravaux
Michèle Reboud-Ravaux
Published Erratum
Biologie aujourd'hui. 2021;215(3-4):143. DOI:10.1051/jbio/2022001 2021
André Calas
André Calas
[Evaluation of different procedures for the extraction of phenolic compounds from a medicinal plant: Verbena officinalis] [0.03%]
不同提取方式提取Verbena officinalis中酚类物质的比较研究
Hanen Falleh,Chokri Hafsi,Ichrak Mohsni et al.
Hanen Falleh et al.
Since ancient times, plants have been the main source of bioactive molecules, such as phenolic compounds, capable of remedying various diseases. However, polyphenols' content and efficiency vary greatly as a function of several intrinsic an...
[Physiological role of the apelin receptor: implication in body fluid homeostasis and hyponatremia] [0.03%]
阿普林受体的生理作用：在体液平衡和低钠血症中的意义
Pierre-Emmanuel Girault-Sotias,Nadia De Mota,Catherine Llorens-Cortès
Pierre-Emmanuel Girault-Sotias
Apelin, a vasoactive neuropeptide, its receptor and arginine-vasopressin (AVP, antidiuretic hormone) are co-localized in magnocellular vasopressinergic neurons. In the kidney, the apelin receptor is present in glomerular arterioles and the ...
[β-arrestins, their mechanisms of action and multiple roles in the biology of G protein-coupled receptors] [0.03%]
[β-逮捕蛋白及其在G蛋白偶联受体生物学中的作用机制和多种作用]
Eric Reiter
Eric Reiter
The stimulation of G protein-coupled receptors (GPCRs) induces biological responses to a wide range of extracellular cues. The heterotrimeric G proteins, which are recruited to the active conformation of GPCRs, lead to the generation of var...
[G proteins: privileged transducers of 7-transmembrane spanning receptors] [0.03%]
[G蛋白：七次跨膜受体的特有转换器]
Julien Hanson
Julien Hanson
G protein-coupled receptors or GPCR are the most abundant membrane receptors in our genome with around 800 members. They play an essential role in most physiological and pathophysiological phenomena. In addition, they constitute 30% of the ...
[Recent advances in the structural biology of the class C G protein-coupled receptors: The metabotropic Glutamate receptor 5] [0.03%]
[M型谷氨酸受体5的结构生物学新进展]
Ludovic Berto,Anaëlle Dumazer,Fanny Malhaire et al.
Ludovic Berto et al.
Class C GPCRs, that include metabotropic glutamate receptors (mGlu), taste receptors, GABAB receptor and Calcium-sensing receptor, are unusual in terms of their molecular architecture and allosteric regulation. They all form obligatory dime...
[Obesity, inflammation and COVID-19: preventive interest of ketogenic diet?] [0.03%]
[肥胖、炎症和COVID-19：酮体饮食的预防作用？]
Anouk Charlot,Rimel Boumiza,Margot Roux et al.
Anouk Charlot et al.
Obesity is considered a pandemic responsible for millions of deaths worldwide for many years. At the end of 2019, the Coronavirus disease 2019 (COVID-19) appeared, causing the death of more than a million people in less than a year. Numerou...