Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma [0.03%]
TFIIIB亚基和RNA聚合酶III基因的异常表达与肝细胞癌相关性研究
Junxia Lei,Songlin Chen,Shuping Zhong
Junxia Lei
The levels of the products of RNA polymerase III-dependent genes (Pol III genes), including tRNAs and 5S rRNA, are elevated in transformed and tumor cells, which potentiate tumorigenesis. TFIIB-related factor 1 (Brf1) is a key transcription...
Adam Bria,Jorgessen Marda,Junmei Zhou et al.
Adam Bria et al.
The liver possesses an extraordinary ability to regenerate after injury. Hepatocyte-driven liver regeneration is the default pathway in response to mild-to-moderate acute liver damage. When replication of mature hepatocytes is blocked, facu...
Wilson disease: At the crossroads between genetics and epigenetics-A review of the evidence [0.03%]
威尔森病：遗传和表观遗传的交叉点-证据综述
Dorothy A Kieffer,Valentina Medici
Dorothy A Kieffer
Environmental factors, including diet, exercise, stress, and toxins, profoundly impact disease phenotypes. This review examines how Wilson disease (WD), an autosomal recessive genetic disorder, is influenced by genetic and environmental inp...
Activating transcription factor 3 in immune response and metabolic regulation [0.03%]
活化转录因子3在免疫反应和代谢调控中的作用
Kavita Jadhav,Yanqiao Zhang
Kavita Jadhav
Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP-response element binding protein (CREB) family of transcription factors. In response to stress stimuli, ATF3 forms dimers to activate or repress gene expression. Further, ...
Komal Ramani,Shelly C Lu
Komal Ramani
Methionine adenosyltransferases (MATs) are essential for cell survival because they catalyze the biosynthesis of the biological methyl donor S-adenosylmethionine (SAMe) from methionine and adenosine triphosphate (ATP). Mammalian cells expre...
Mengxi Jiang,Meishu Xu,Songrong Ren et al.
Mengxi Jiang et al.
Background and aim: Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and exo...
Phillip B Hylemon,Kazuaki Takabe,Mikhail Dozmorov et al.
Phillip B Hylemon et al.
Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines. BAs are hormones that regulate nutrient metabolism by ...
Adipose tissue autophagy and homeostasis in alcohol-induced liver injury [0.03%]
酒精诱导的肝损伤中的脂肪组织自噬和稳态
Yuan Li,Wen-Xing Ding
Yuan Li
Alcohol consumption leads to injury in multiple organs and systems, including the liver, brain, heart, skeletal muscle, pancreas, bone, immune system, and endocrine system. Emerging evidence indicates that alcohol also promotes adipose tiss...
John Y L Chiang
John Y L Chiang
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR...
Jibiao Li,Tiangang Li
Jibiao Li
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease in Western populations. Non-alcoholic steatohepatitis (NASH) is a more debilitating form of NAFLD characterized by hepatocellular injury and inflammation, which significant...