Targeting nuclear receptors for NASH/MASH: From bench to bedside [0.03%]
瞄准核受体治疗非酒精性/代谢相关脂肪肝病：从实验室到临床
Rohit A Sinha
Rohit A Sinha
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now t...
Loss of hepatic VMP1 trapped VLDL in the bilayer of endoplasmic reticulum membrane☆ [0.03%]
肝VMP1的缺失使VLDL被困在内质网膜的双层中☆
Hong-Min Ni,Benjamin Ding,Allen Chen
Hong-Min Ni
Effects of Bacillus Calmette-Guérin on immunometabolism, microbiome and liver diseases⋆ [0.03%]
卡介苗对免疫代谢、微生物群和肝脏疾病的影响⋆
Muhammad Umair Ijaz,Farzam Vaziri,Yu-Jui Yvonne Wan
Muhammad Umair Ijaz
Metabolic diseases have overtaken infectious diseases as the most serious public health issue and economic burden in most countries. Moreover, metabolic diseases increase the risk of having infectious diseases. The treatment of metabolic di...
The contributions of bacteria metabolites to the development of hepatic encephalopathy [0.03%]
细菌代谢产物对肝性脑病发生发展的影响
Miranda Claire Gilbert,Tahereh Setayesh,Yu-Jui Yvonne Wan
Miranda Claire Gilbert
Over 20% of mortality during acute liver failure is associated with the development of hepatic encephalopathy (HE). Thus, HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities ranging from subcl...
Discordance among aggressiveness characteristics of hepatocellular carcinoma: Portal vein thrombosis and multifocality, related to tumor size, but not to serum alpha-fetoprotein level [0.03%]
肝细胞癌侵袭性特征之间的不一致性：门静脉血栓和多灶性与肿瘤大小有关，但与血清甲胎蛋白水平无关
Brian I Carr,Vito Guerra,Volkan Ince et al.
Brian I Carr et al.
Background and aims: Hepatocellular carcinoma (HCC) is characterized by several clinically important prognostic parameters, including portal vein thrombosis (PVT), tumor multifocality, and serum alpha-fetoprotein (AFP) le...
Fathima N Cassim Bawa,Yanqiao Zhang
Fathima N Cassim Bawa
Retinoic acid (RA) is a metabolite of vitamin A and is essential for development and growth as well as cellular metabolism. Through genomic and nongenomic actions, RA regulates a variety of physiological functions. Dysregulation of RA signa...
Liver-adipose tissue crosstalk in alcohol-associated liver disease: The role of mTOR [0.03%]
酒精相关性肝病中肝脏-脂肪组织互作：mTOR的作用
Yssa Rodriguez,Jack Dunfield,Tyson Roderique et al.
Yssa Rodriguez et al.
Background: Alcohol-associated liver disease (ALD) is a major chronic liver disease around the world without successful treatment. Acute alcoholic hepatitis is one of the most severe forms of ALD with high mortality, whic...
Hepatic transcriptome profiling reveals early signatures associated with disease transition from non-alcoholic steatosis to steatohepatitis [0.03%]
肝转录组分析揭示非酒精性脂肪肝向非酒精性脂肪性肝炎转变的早期特征标志
Nancy Magee,Forkan Ahamed,Natalie Eppler et al.
Nancy Magee et al.
Background and aim: Non-alcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease worldwide. The molecular events that influence disease progression from non-alcoholic fatty liver (NAFL) t...
Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis [0.03%]
胆盐apia通道抑制剂联合obe治疗实验性非酒精性肝炎的效果研究
David J Matye,Xuan Qin,Mohammad Nazmul Hasan et al.
David J Matye et al.
Background and aims: Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis (NASH) treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver...
Recent insights into the pathogeneses and therapeutic targets of liver diseases: Summary of the 4th Chinese American Liver Society/Society of Chinese Bioscientists in America Hepatology Division Symposium in 2021 [0.03%]
肝病发病机制和治疗靶点的最新研究进展——第4届美中肝脏病学研讨会概要
Wen-Xing Ding,Hua Wang,Yuxia Zhang
Wen-Xing Ding
The 4th Chinese American Liver Society (CALS)/Society of Chinese Bioscientists in America (SCBA) Hepatology Division Annual Symposium was held virtually on October 29-30, 2021. The goal of the CALS Symposium was to present and discuss the r...