Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis [0.03%]
酒精性肝硬化患者循环滤泡辅助T细胞、Th1细胞水平及CD40配体可溶形式对生存预后的预测价值
Kristin Hollister,Praveen Kusumanchi,Ruth Ann Ross et al.
Kristin Hollister et al.
Background: Excessive drinkers (ED) and patients with alcoholic liver disease (ALD) are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations. Follicula...
Jingyan Tian,Silvia Huang,Siming Sun et al.
Jingyan Tian et al.
The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications. Bariatric surgical procedures, such as Roux-en-Y gastric...
Zhanxiang Zhou,Wei Zhong
Zhanxiang Zhou
Alcohol consumption remains one of the predominant causes of liver disease and liver-related death worldwide. Intriguingly, dysregulation of the gut barrier is a key factor promoting the pathogenesis of alcoholic liver disease (ALD). A func...
X Charlie Dong
X Charlie Dong
Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disorder that begins with simple hepatic steatosis and progresses to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and even liver cancer. As the global prevalenc...
James H Tabibian,Christopher L Bowlus
James H Tabibian
Primary sclerosing cholangitis (PSC) is a rare, chronic, cholestatic liver disease of uncertain etiology characterized biochemically by cholestasis and histologically and cholangiographically by fibro-obliterative inflammation of the bile d...
Recent development and gene therapy for glycogen storage disease type Ia [0.03%]
近期糖原累积症Ia型的发病情况及其基因治疗
Janice Y Chou,Goo-Young Kim,Jun-Ho Cho
Janice Y Chou
Glycogen storage disease type Ia (GSD-Ia) is an autosomal recessive metabolic disorder caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) that is expressed primarily in the liver, kidney, and intestine. G6Pase-α catalyz...
Yulan Zhao,Jianguo Wu,Suthat Liangpunsakul et al.
Yulan Zhao et al.
Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length but lacking identifiable open reading frames (with rare exceptions). Herein, we highlight emerging evidence demonstrating that lncRNAs are c...
Fengyan Deng,Nancy Magee,Yuxia Zhang
Fengyan Deng
Cell-to-cell communication is a fascinating process that is essential for maintaining tissue and whole-body homeostasis. Extracellular vesicles (EVs) are cell-derived membrane-bound nanoparticles that are a means of communication between ce...
Joanne Thomson,Laura Hargrove,Lindsey Kennedy et al.
Joanne Thomson et al.
The functions of the liver are very diverse. From detoxifying blood to storing glucose in the form of glycogen and producing bile to facilitate fat digestion, the liver is a very active and important organ. The liver is comprised of many va...
Interaction between stress responses and circadian metabolism in metabolic disease [0.03%]
应激反应和昼夜节律代谢在代谢性疾病中的相互作用
Zhao Yang,Hyunbae Kim,Arushana Ali et al.
Zhao Yang et al.
Circadian rhythms play crucial roles in orchestrating diverse physiological processes that are critical for health and disease. Dysregulated circadian rhythms are closely associated with various human metabolic diseases, including type 2 di...