Lijun Wang,Yu-Jui Yvonne Wan
Lijun Wang
Liver cancer is the sixth most common cancer worldwide, and the third most common cause of cancer-related death. Hepatocellular carcinoma (HCC), which accounts for more than 90% of primary liver cancers, is an important public health proble...
Alexander L Ticho,Pooja Malhotra,Pradeep K Dudeja et al.
Alexander L Ticho et al.
Bile acids modulate several gastrointestinal functions including electrolyte secretion and absorption, gastric emptying, and small intestinal and colonic motility. High concentrations of bile acids lead to diarrhea and are implicated in the...
Alcohol and drug-induced liver injury: Metabolism, mechanisms, pathogenesis and potential therapies☆ [0.03%]
酒精和药物所致肝损伤：代谢、机制、发病机制及潜在治疗方法
Wen-Xing Ding,Li Yang
Wen-Xing Ding
Yu-Jui Yvonne Wan,Lili Sheng
Yu-Jui Yvonne Wan
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein r...
Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist [0.03%]
胆汁淤积性肝病的预防性护理：专家和专科医师的经验之谈
Adnan Malik,Ani A Kardashian,Kais Zakharia et al.
Adnan Malik et al.
Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Man...
Autophagy in liver diseases: A matter of what to remove and whether to keep [0.03%]
自噬在肝病中的作用：降什么恶魔，留什么仁慈
Xiao-Ming Yin
Xiao-Ming Yin
The acidic pathway of bile acid synthesis: Not just an alternative pathway☆ [0.03%]
胆汁酸合成的酸性途径：不仅仅是替代途径
William M Pandak,Genta Kakiyama
William M Pandak
Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have dramatically increased. Bile acids play a major role in the diges...
Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation [0.03%]
氯丙嗪通过调节自噬和c-Jun氨基末端激酶活化来预防对乙酰氨基酚致小鼠肝损伤
Yuan Li,Hong-Min Ni,Hartmut Jaeschke et al.
Yuan Li et al.
Background and aim: Overdose of acetaminophen (APAP) leads to liver injury, which is one of the most common causes of liver failure in the United States. We previously demonstrated that pharmacological activation of autop...
Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis [0.03%]
丙酮酸脱氢酶激酶4缺乏通过诱导凋亡增加小鼠肝脏对亚硝基二乙胺和砷毒性的敏感性
Jonathan Choiniere,Matthew Junda Lin,Li Wang et al.
Jonathan Choiniere et al.
Background and aim: Pyruvate dehydrogenase kinase 4 (PDK4) is a metabolism switch that regulates glucose oxidation and the tricarboxylic acid cycle (TCA cycle) in the mitochondria. Liver detoxifies xenobiotics and is cons...
Regulation of the homeostasis of hepatic endoplasmic reticulum and cytochrome P450 enzymes by autophagy [0.03%]
自噬对肝脏内质网稳态和细胞色素P450酶的调节作用研究进展
Xiaowen Ma,Clayre Parson,Wen-Xing Ding
Xiaowen Ma
The endoplasmic reticulum (ER) is an intracellular organelle consisting of a continuous network of membranes. In the liver, the ER is highly active in protein modification, lipid metabolism, and xenobiotic detoxification. Maintaining these ...