Glypican-3: A molecular marker for the detection and treatment of hepatocellular carcinoma☆ [0.03%]
glypican-3：用于检测和治疗肝细胞癌的分子标志物
Tsung-Chieh Shih,Lijun Wang,Hsiao-Chi Wang et al.
Tsung-Chieh Shih et al.
Hepatocellular carcinoma (HCC) is a malignant tumor with a fairly poor prognosis (5-year survival of less than 50%). Using sorafenib, the only food and drug administration (FDA)-approved drug, HCC cannot be effectively treated; it can only ...
Hepatocellular carcinoma immunotherapy: The impact of epigenetic drugs and the gut microbiome [0.03%]
肝细胞癌免疫治疗：表观遗传药物和肠道微生物群的影响
Farzam Vaziri,Steven Colquhoun,Yu-Jui Yvonne Wan
Farzam Vaziri
The incidence of hepatocellular carcinoma (HCC) has been increasing for decades. This disease has now risen to become the sixth most common malignancy overall, while ranking as the third most frequent cause of cancer mortality. While severa...
Yanan Wang,Yu-Jui Yvonne Wan
Yanan Wang
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a low survival rate. The identification of mechanisms underlying the development of HCC helps uncover cellular and molecular targets for the diagnosis, preventio...
Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect [0.03%]
脂质体氯膦酸盐的两次预处理通过预处理效应保护肝脏免受对乙酰氨基酚毒性伤害
Melissa M Clemens,Joel H Vazquez,Stefanie Kennon-McGill et al.
Melissa M Clemens et al.
Background and aim: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in propagation of the hepatotoxicity is controversial. Early research revealed that macrophage inhibito...
Lijun Wang,Yu-Shiuan Wang,Eko Mugiyanto et al.
Lijun Wang et al.
With obesity rate consistently increasing, a strong relationship between obesity and fatty liver disease has been discovered. More than 90% of bariatric surgery patients also have non-alcoholic fatty liver diseases (NAFLDs). NAFLD and non-a...
Multidisciplinary, three-dimensional and individualized comprehensive treatment for severe/critical COVID-19 [0.03%]
针对严重/危重COVID-19的多学科、三维和个体化综合治疗
Medical Panel of Severe/Critical COVID-;Third Affiliated Hospital of Sun Yat-sen University
Medical Panel of Severe/Critical COVID-;Third Affiliated Hospital of Sun Yat-sen University
Severe/critical cases account for 18-20% of all novel coronavirus disease 2019 (COVID-19) patients, but their mortality rate can be up to 61.5%. Furthermore, all deceased patients were severe/critical cases. The main reasons for the high mo...
Tagreed A Mazi,Noreene M Shibata,Valentina Medici
Tagreed A Mazi
Copper accumulation and deficiency are reciprocally connected to lipid metabolism. In Wilson disease (WD), which is caused by a genetic loss of function of the copper-transporting P-type ATPase beta, copper accumulates mainly in the liver a...
Structural Perspectives of the CYP3A Family and Their Small Molecule Modulators in Drug Metabolism [0.03%]
药物代谢中CYP3A家族及其小分子调节因子的结构观点
William C Wright,Jude Chenge,Taosheng Chen
William C Wright
Cytochrome P450 enzymes function to catalyze a wide range of reactions, many of which are critically important for drug response. Members of the human cytochrome P450 3A (CYP3A) family are particularly important in drug clearance, and they ...
Xiaoying Liu,Richard M Green
Xiaoying Liu
Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring enzyme 1α (IRE1α), PKR-l...
Mitochondrial Damage and Biogenesis in Acetaminophen-induced Liver Injury [0.03%]
乙酰氨基酚致肝损伤时线粒体的损害和新生
Hartmut Jaeschke,Luqi Duan,Nga Nguyen et al.
Hartmut Jaeschke et al.
Liver injury and acute liver failure caused by acetaminophen (APAP) overdose is the clinically most important drug toxicity in western countries. Mechanistic investigations have revealed a central role of mitochondria in the pathophysiology...