A fluorescence imaging based-assay to monitor mitophagy in cultured hepatocytes and mouse liver [0.03%]
一种基于荧光成像的检测培养肝细胞和小鼠肝脏线粒体自噬的方法
Xiaowen Ma,Wen-Xing Ding
Xiaowen Ma
Background and aim: Mitophagy is a lysosomal degradation pathway that selectively removes damaged, aged and dysfunctional mitochondria. Recent advances in understanding mitophagy highlight its importance in various physio...
Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation [0.03%]
向野生型小鼠移植Pfkfb3缺陷的造血细胞加剧饮食诱导的肝脂肪变性和炎症反应
Xin Guo,Bilian Zhu,Hang Xu et al.
Xin Guo et al.
Background and objectives: Hepatic steatosis and inflammation are key characteristics of non-alcoholic fatty liver disease (NAFLD). However, whether and how hepatic steatosis and liver inflammation are differentially regu...
Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis [0.03%]
胆固醇7α-羟化酶(CYP7A1)在胆汁酸合成中的作用最新研究进展
John Y L Chiang,Jessica M Ferrell
John Y L Chiang
Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the...
Sana Raza,Archana Tewari,Sangam Rajak et al.
Sana Raza et al.
The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly across the globe. NAFLD pathogenesis is largely driven by an imbalance in hepatic energy metabolism and at present, there is no approved drug for its treatment. Th...
Fengyuan Li,Craig J McClain,Wenke Feng
Fengyuan Li
Microbiome dysbiosis is strongly associated with alcoholic liver disease (ALD). Recent studies on comprehensive analyses of microbiome compositional and functional changes have begun to uncover the mechanistic relation between microbiome an...
Incidence, mortality, and risk factors of immunotherapy-associated hepatotoxicity: A nationwide hospitalization analysis [0.03%]
免疫治疗相关肝毒性的发生率、死亡率和危险因素：基于全国住院患者的分析
Simcha Weissman,Saad Saleem,Sachit Sharma et al.
Simcha Weissman et al.
Background and aims: Anti-neoplastic immunotherapy has revolutionized cancer management; however. its safety profile with respect to liver-related injury remains largely unexplored. Herein, we analyzed a United States nat...
Ryan J Schulze,Wen-Xing Ding
Ryan J Schulze
The rising incidence of alcohol-related liver disease (ALD) demands making urgent progress in understanding the fundamental molecular basis of alcohol-related hepatocellular damage. One of the key early events accompanying chronic alcohol u...
Yes-associated protein-1 may serve as a diagnostic marker and therapeutic target for residual/recurrent hepatocellular carcinoma post-transarterial chemoembolization☆ [0.03%]
耶尔森氏菌蛋白-1可能是经动脉化疗栓塞术后肝细胞癌残留/复发诊断标志物及治疗靶点
Xia Qian,Wei Zhang,Alireza Shams et al.
Xia Qian et al.
Background and aim: The transcriptional co-activator Yes-associated protein-1 (YAP1) has been implicated as an oncogene and is overexpressed in different kinds of human cancers, especially hepatocellular carcinoma (HCC). ...
Impact of liver enzymes on SARS-CoV-2 infection and the severity of clinical course of COVID-19 [0.03%]
肝酶对SARS-CoV-2感染及COVID-19临床过程严重性的影响
Fátima Higuera-de la Tijera,Alfredo Servín-Caamaño,Daniel Reyes-Herrera et al.
Fátima Higuera-de la Tijera et al.
Background and aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the current pandemic, can have multi-organ impact. Recent studies show that liver injury could be a manifestation...
Steven D Colquhoun,Yu-Jui Yvonne Wan
Steven D Colquhoun