Gut microbiome in liver pathophysiology and cholestatic liver disease [0.03%]
肠道微生物群在肝脏病理生理和胆汁淤积性肝病中的作用
Shengmin Yan,Xiao-Ming Yin
Shengmin Yan
An increasing amount of evidence has shown critical roles of gut microbiome in host pathophysiology. The gut and the liver are anatomically and physiologically connected. Given the critical role of gut-liver axis in the homeostasis of the l...
Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis [0.03%]
机器学习模型与现有胆总管结石内镜逆行胰胆管造影检查确诊标准的对比评估：一项回顾性研究
Camellia Dalai,John Azizian,Harry Trieu et al.
Camellia Dalai et al.
Background and aims: Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics. We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiop...
Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice [0.03%]
肝脏特异性敲除microRNA-185引起小鼠胆固醇紊乱
Cheng Chen,David Matye,Yifeng Wang et al.
Cheng Chen et al.
Background: The liver plays a key role in regulating whole body cholesterol homeostasis. Hepatic cholesterol accumulation causes liver injury in fatty liver disease and hypercholesterolemia increases the risk of cardiovas...
A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice [0.03%]
一种临床上有意义的多柔比星和环磷酰胺联合治疗在C57BL/6J小鼠中不诱导肝毒性
Satyanarayana R Pondugula,Julia M Salamat,Kodye L Abbott et al.
Satyanarayana R Pondugula et al.
Background and aim: Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity. A combination chemotherapy regimen of doxorubicin (DOX) and cyclophosphamide (CPS) is employed in treat...
Fang Wang,Peter Breslin S J,Wei Qiu
Fang Wang
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activati...
The clinical implication of gamma-glutamyl transpeptidase in COVID-19 [0.03%]
COVID-19中γ-谷氨酰转肽酶的临床意义
Jianrong Liu,Chao Yu,Qing Yang et al.
Jianrong Liu et al.
Background and aim: Coronavirus disease 2019 (COVID-19) is a life-threatening disease that predominantly causes respiratory failure. The impact of COVID-19 on other organs remains elusive. Herein, we aimed to investigate ...
Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma [0.03%]
肝细胞癌中半乳糖凝集素-1和半乳糖凝集素-3的过表达
Tahereh Setayesh,Steven D Colquhoun,Yu-Jui Yvonne Wan
Tahereh Setayesh
Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans. Abnormal expression of Gals is associated with the development, progression, and metastasis of different types of cancer. Among the 11 Ga...
Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice [0.03%]
雷帕霉素靶蛋白肝脏特异性敲除小鼠不能抵抗乙酰氨基酚所致的肝损伤
Hua Sun,Hong-Min Ni,Jennifer M McCracken et al.
Hua Sun et al.
Background: Acetaminophen (APAP) overdose can cause liver injury and liver failure, which is one of the most common causes of drug-induced liver injury in the United States. Pharmacological activation of autophagy by inhi...
Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances [0.03%]
胆泥与微结石的异同及其临床和病理生理意义
Helen H Wang,Piero Portincasa,Min Liu et al.
Helen H Wang et al.
The terms biliary sludge and cholesterol microlithiasis (hereafter referred to as microlithiasis) were originated from different diagnostic techniques and may represent different stages of cholesterol gallstone disease. Although the pathoge...
New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile [0.03%]
Lith基因在胆固醇过饱和胆汁形成中作用的最新认识
Helen H Wang,Tiangang Li,Piero Portincasa et al.
Helen H Wang et al.
Cholesterol gallstone formation represents a failure of biliary cholesterol homeostasis in which the physical-chemical balance of cholesterol solubility in bile is disturbed. Lithogenic bile is mainly caused by persistent hepatic hypersecre...