Reciprocal translocation experiments reveal gut microbiome plasticity and host specificity in a Qinghai-Xizang Plateau lizard [0.03%]
互为供受体实验揭示了高原蜥蜴肠道微生物组的宿主特异性和可塑性
Wei Yu,Jing Yang,Li-Wei Teng et al.
Wei Yu et al.
Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition. The gut microbiome, highly responsive to external environmental factors, plays a c...
Transcription coactivator YAP1 promotes CCND1/CDK6 expression, stimulating cell proliferation in cloned cattle placentas [0.03%]
转录共激活因子YAP1通过促进CCND1/CDK6表达刺激克隆牛胎盘细胞增殖
Shan-Shan Wu,Xiao-Yu Zhao,Lei Yang et al.
Shan-Shan Wu et al.
Somatic cell nuclear transfer (SCNT) has been successfully employed across various mammalian species, yet cloned animals consistently exhibit low pregnancy rates, primarily due to placental abnormalities such as hyperplasia and hypertrophy....
Identification of novel rodent and shrew orthohepeviruses sheds light on hepatitis E virus evolution [0.03%]
新型啮齿动物和鼩鼱正 Hep E 病毒的鉴定为肝炎病毒进化提供线索
Fu-Li Li,Bo Wang,Pei-Yu Han et al.
Fu-Li Li et al.
The family Hepeviridae has seen an explosive expansion in its host range in recent years, yet the evolutionary trajectory of this zoonotic pathogen remains largely unknown. The emergence of rat hepatitis E virus (HEV) has introduced a new p...
DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a [0.03%]
DNA2敲除通过减少突触后Homer1a的表达加重脑缺血再灌注损伤
Ting Ma,Yu-Meng Li,Peng-Yu Ren et al.
Ting Ma et al.
DNA2, a multifunctional enzyme with structure-specific nuclease, 5 '-to-3 ' helicase, and DNA-dependent ATPase activities, plays a pivotal role in the cellular response to DNA damage. However, its involvement in cerebral ischemia/reperfusio...
Transposable elements shape the landscape of heterozygous structural variation in a bird genome [0.03%]
转座元件塑造了鸟类基因组杂合结构变异的景观
Bo-Ping Li,Na Kang,Zao-Xu Xu et al.
Bo-Ping Li et al.
Avian genomes exhibit compact organization and remarkable chromosomal stability. However, the extent and mechanisms by which structural variation in avian genomes differ from those in other vertebrate lineages are poorly explored. This stud...
Ribosome profiling and single-cell RNA sequencing identify the unfolded protein response as a key regulator of pigeon lactation [0.03%]
核糖体分析和单细胞RNA测序鉴定未折叠蛋白反应作为鸽子泌乳的关键调节因子
Jing Liu,San-Feng Liu,Hui-Rong Mao et al.
Jing Liu et al.
Pigeons and certain other avian species produce a milk-like secretion in their crop sacs to nourish offspring, yet the detailed processes involved are not fully elucidated. This study investigated the crop sacs of 225-day-old unpaired non-l...
Novel mouse model of Alzheimer's disease exhibits pathology through synergistic interactions among amyloid-β, tau, and reactive astrogliosis [0.03%]
一种新颖的小鼠模型表现出通过淀粉样蛋白、tau和反应性星形胶质细胞增生之间的协同作用形成的病理性变化，可模拟阿尔茨海默病病理特征
Young-Eun Han,Sunhwa Lim,Seung Eun Lee et al.
Young-Eun Han et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment and distinct neuropathological features, including amyloid-β plaques, neurofibrillary tangles, and reactive astrogliosis. Developing...
Both 20S and 19S proteasome components are essential for meiosis in male mice [0.03%]
20S和19S蛋白酶体成分对于雄性小鼠减数分裂都是必不可少的
Ting-Ting Han,Li-Ying Wang,Qiu-Xing Zhou et al.
Ting-Ting Han et al.
The proteasome, an evolutionarily conserved proteolytic complex comprising the 20S core particle and 19S regulatory particles, performs both shared and distinct functions across various tissues and organs. Spermatogenesis, a highly complex ...
Enhanced risk assessment framework integrating distribution dynamics, genetically inferred populations, and morphological traits of Diploderma lizards [0.03%]
结合分布动力学、遗传推断种群和形态特征的Diploderma蜥蜴增强风险评估框架
Qi Xiao,Xiu-Dong Shi,Lin Shi et al.
Qi Xiao et al.
Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts. However, current frameworks, even the IUCN Red List, often neglect critical factors such as genetic divers...
Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation [0.03%]
长鳍豚科动物中棕榈酰化介导的NLRP3炎性小体激活强调了免疫调节中的进化分歧
Li Nie,Xiang-Yu Wu,Zi-Yue Zhao et al.
Li Nie et al.
NLRP3 inflammasome activation is pivotal for cytokine secretion and pyroptosis in response to diverse stimuli, playing a crucial role in innate immunity. While extensively studied in mammals, the regulatory mechanisms governing NLRP3 activa...