King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates [0.03%]
从临床耐药菌株中筛选眼镜王蛇OH-CATH30肽作为潜在药物分子候选物的研究
Feng Zhao,Xin-Qiang Lan,Yan Du et al.
Feng Zhao et al.
Cationic antimicrobial peptides (AMPs) are considered as important candidate therapeutic agents, which exert potent microbicidal properties against bacteria, fungi and some viruses. Based on our previous findings king cobra cathelicidin (OH...
Kidney disease models: tools to identify mechanisms and potential therapeutic targets [0.03%]
肾脏疾病模型：识别发病机制和潜在治疗靶点的工具
Yin-Wu Bao,Yuan Yuan,Jiang-Hua Chen et al.
Yin-Wu Bao et al.
Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal ...
In vivo genome editing thrives with diversified CRISPR technologies [0.03%]
多样化的CRISPR技术促进体内基因组编辑蓬勃发展
Xun Ma,Avery Sum-Yu Wong,Hei-Yin Tam et al.
Xun Ma et al.
Prokaryotic type II adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in site-specific genome editing and has revolutionized biomedical research due to its superior efficiency an...
Murine model of acute myocarditis and cerebral cortical neuron edema induced by coxsackievirus B4 [0.03%]
柯萨奇病毒B4诱导的小鼠急性心肌炎和脑皮层神经元肿胀模型研究
Zhao-Peng Dong,Qian Wang,Zhen-Jie Zhang et al.
Zhao-Peng Dong et al.
Globally, coxsackievirus B4 (CV-B4) has been continuously isolated and evidence suggests an association with the development of pancreatitis and type I diabetes. In addition, CV-B4 is also associated with myocarditis and severe central nerv...
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 [0.03%]
寄生虫可能存在于免疫功能低下的感染了SIVmac239的北部猪尾猕猴（Macaca leonina）中
Tian-Zhang Song,Ming-Xu Zhang,Yu-Jie Xia et al.
Tian-Zhang Song et al.
Parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus (HIV) patients. However, in vitro studies and epidemiological investigations also suggest that parasites might escape immunocompromis...
Gary Wong,Wen-Guang Cao,Shi-Hua He et al.
Gary Wong et al.
The Angolan strain of Marburg virus (MARV/Ang) can cause lethal disease in humans with a case fatality rate of up to 90%, but infection of immunocompetent rodents do not result in any observable symptoms. Our previous work includes the deve...
Wei-Na Guo,Bin Zhu,Ling Ai et al.
Wei-Na Guo et al.
Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B....
Vinayakumar Siragam,Gary Wong,Xiang-Guo Qiu
Vinayakumar Siragam
The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal mo...
Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential [0.03%]
一类干扰素受体敲除小鼠作为高致病性潜在暴发病毒的感染模型
Gary Wong,Xiang-Guo Qiu
Gary Wong
Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar-/-) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model ha...
Genome size of 14 species of fireflies (Insecta, Coleoptera, Lampyridae) [0.03%]
14种萤火虫(昆虫:鞘翅目:萤科)基因组大小测定
Gui-Chun Liu,Zhi-Wei Dong,Jin-Wu He et al.
Gui-Chun Liu et al.
Eukaryotic genome size data are important both as the basis for comparative research into genome evolution and as estimators of the cost and difficulty of genome sequencing programs for non-model organisms. In this study, the genome size of...