Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis) [0.03%]
Chinese树鼩基底细胞癌动物模型的建立
Li-Ping Jiang,Qiu-Shuo Shen,Cui-Ping Yang et al.
Li-Ping Jiang et al.
Basal cell carcinoma (BCC) is the most common skin cancer worldwide, with incidence rates continuing to increase. Ultraviolet radiation is the major environmental risk factor and dysregulation of the Hedgehog (Hh) signaling pathway has been...
Models and detection of spontaneous recurrent seizures in laboratory rodents [0.03%]
实验动物自发性反复癫痫发作的模型与检测
Bin Gu,Katherine A Dalton
Bin Gu
Epilepsy, characterized by spontaneous recurrent seizures (SRS), is a serious and common neurological disorder afflicting an estimated 1% of the population worldwide. Animal experiments, especially those utilizing small laboratory rodents, ...
EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production [0.03%]
EP300通过调节一氧化氮的产生促进藏族人高原适应性
Wang-Shan Zheng,Yao-Xi He,Chao-Ying Cui et al.
Wang-Shan Zheng et al.
The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene EP300 (histone acetylt...
Yong-Bo Guo,Yao-Xi He,Chao-Ying Cui et al.
Yong-Bo Guo et al.
Tibetans are well adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene ( GCH1, GTP-cyclohydrolase I), involve...
Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1 -/-mice infected with influenza virus (H1N1) [0.03%]
肺免疫细胞和炎症细胞因子失调与IL-1R1基因敲除小鼠感染甲型流感病毒(H1N1)后的致死率相关性研究
Lei Guo,Yan-Cui Wang,Jun-Jie Mei et al.
Lei Guo et al.
Respirovirus infection can cause viral pneumonia and acute lung injury (ALI). The interleukin-1 (IL-1) family consists of proinflammatory cytokines that play essential roles in regulating immune and inflammatory responses in vivo. IL-1 sign...
A new species of the genus Amolops (Anura: Ranidae) from high-altitude Sichuan, southwestern China, with a discussion on the taxonomic status of Amolops kangtingensis [0.03%]
中国四川西南部高山地区两栖动物新物种——饰纹华蟾蜍（后附模式标本图）及阿莫氏华蟾蜍的分类地位讨论
Liang Fei,Chang-Yuan Ye,Yu-Fan Wang et al.
Liang Fei et al.
A new species of the genus Amolops Cope, 1865 is described from Xinduqiao, Kangding, Sichuan. It was previously identified as Amolops kangtingensis, which is synonymized to Amolops mantzorum in this study. The new species, Amolops xinduqiao...
Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model [0.03%]
树鼩(Tupaia belangeri)作为新的实验动物模型与人类疾病的关系研究
Ji Xiao,Rong Liu,Ce-Shi Chen
Ji Xiao
The tree shrew (Tupaia belangeri) is a promising laboratory animal that possesses a closer genetic relationship to primates than to rodents. In addition, advantages such as small size, easy breeding, and rapid reproduction make the tree shr...
Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)? [0.03%]
创建模式动物，为什么不去利用中国树鼩（ tupaya belangeri chinensis ）？
Yong-Gang Yao
Yong-Gang Yao
The Chinese tree shrew (Tupaia belangeri chinensis), a squirrel-like and rat-sized mammal, has a wide distribution in Southeast Asia, South and Southwest China and has many unique characteristics that make it suitable for use as an experime...
Greger Larson
Greger Larson