Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2 [0.03%]
刺突蛋白变异和ACE2等位基因多态性影响针对SARS-CoV-2的靶向治疗策略
Chuan-Jun Shu,Xuan Huang,Hui-Hao Tang et al.
Chuan-Jun Shu et al.
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide with high rates of transmission and substantial mortality. To date, however, no effective tre...
Cranial variation in allactagine jerboas (Allactaginae, Dipodidae, Rodentia): a geometric morphometric study [0.03%]
全脊椎大沙鼠（啮齿目跳鼠科沙鼠亚科）头骨几何形态学变异研究
Bader H Alhajeri
Bader H Alhajeri
Allactaginae is a subfamily of dipodids consisting of four- and five-toed jerboas ( Allactaga, Allactodipus, Orientallactaga, Pygeretmus, Scarturus) found in open habitats of Asia and North Africa. Recent molecular phylogenies have upended ...
Cui Yang,Zhi-Lan Liu,Jun Wang et al.
Cui Yang et al.
Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for para...
Flexible breeding performance under unstable climatic conditions in a tropical passerine in Southwest China [0.03%]
中国西南部一只过客鸟在不稳定气候条件下的灵活繁殖性能
Chen-Yang Liu,Uriel Gélin,Ru-Chuan He et al.
Chen-Yang Liu et al.
Parents may adjust their breeding time to optimize reproductive output and reduce reproductive costs associated with unpredictable climatic conditions, especially in the context of global warming. The breeding performance of tropical bird s...
Ancestral developmental potentials in early bony fish contributed to vertebrate water-to-land transition [0.03%]
早期硬骨鱼的祖先发育潜能对脊椎动物从水生到陆生的过渡做出了贡献
Xu-Peng Bi,Guo-Jie Zhang
Xu-Peng Bi
The water-to-land transition was a major step in vertebrate evolution and eventually gave rise to the tetrapods, including amphibians, reptiles, birds, and mammals. The first land invasion of our fish ancestors is considered to have occurre...
A novel machine learning approach (svmSomatic) to distinguish somatic and germline mutations using next-generation sequencing data [0.03%]
一种新型机器学习方法(svmSomatic)：利用下一代测序数据区分体细胞突变和胚系突变
Yu-Fang Mao,Xi-Guo Yuan,Yu-Peng Cun
Yu-Fang Mao
Somatic mutations are a large category of genetic variations, which play an essential role in tumorigenesis. Detection of somatic single nucleotide variants (SNVs) could facilitate downstream analysis of tumorigenesis. Many computational me...
A new species of the genus Micryletta (Anura, Microhylidae) from Hainan Island, China [0.03%]
中国海南岛姬树蛙新种描述（无尾目，微小蛙科）
Jian-Huan Yang,Nikolay A Poyarkov
Jian-Huan Yang
We report on a new amphibian species of the genus Micryletta from Hainan Island, China, based on morphological and molecular analyses. The new species, Micryletta immaculata sp. nov., is diagnosed by a combination of the following morpholog...
Comparative transcriptomics highlights convergent evolution of energy metabolic pathways in group-living spiders [0.03%]
比较转录组学揭示了群居蜘蛛能量代谢途径的趋同进化
Han Yang,Bin Lyu,Hai-Qiang Yin et al.
Han Yang et al.
Although widely thought to be aggressive, solitary, and potentially cannibalistic, some spider species have evolved group-living behaviors. The distinct transition provides the framework to uncover group-living evolution. Here, we conducted...
Biological implications and limitations of a cynomolgus monkey with naturally occurring Parkinson's disease [0.03%]
食蟹猴自然发生的帕金森病的生物学意义和局限性
Hao Li,Yong-Gang Yao,Xin-Tian Hu
Hao Li
We recently identified a cynomolgus monkey with naturally occurring Parkinson's disease (PD), indicating that PD may not be a uniquely human disease (Li et al, 2020). In our previous study, four lines of evidence, including typical PD clini...
Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study [0.03%]
下呼吸道样本可靠用于严重急性呼吸系统综合症冠状病毒2核酸检测及动物模型研究
Ren-Rong Tian,Cui-Xian Yang,Mi Zhang et al.
Ren-Rong Tian et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) continue to impact countries worldwide. At present, inadequate diagnosis and unreliable evaluation systems hinder the implementation and de...