Insights into the role of Fsh signaling in ovarian differentiation of chorionic gonadotropin α ( cgα)-deficient zebrafish [0.03%]
Fsh信号在合胞素α(cgα)缺陷斑马鱼卵巢分化中的作用机制研究
Chuang Shi,Yuqing Zhang,Yao Lu et al.
Chuang Shi et al.
Chorionic gonadotropin α (Cgα) functions as the shared subunit for thyroid-stimulating hormone subunit β (Tshβ), luteinizing hormone subunit β (Lhβ), and follicle-stimulating hormone subunit β (Fshβ). While these β-subunits have be...
Adaptive evolution of BMP4 as a potential mechanism for flipper forelimb changes in cetaceans [0.03%]
bmp4的适应性演化及其在鲸目动物鳍肢变化中的潜在作用
Yao Liu,Luo-Ying Deme,Jia Liu et al.
Yao Liu et al.
Vertebrate limbs have undergone profound morphological diversification, enabling adaptations to a broad spectrum of ecological niches. In marine mammals, the evolution of highly specialized flipper-like forelimbs represents a profound struc...
Evolutionary balance between genomic conservation and coral reef adaptation in the yellow boxfish ( Ostracion cubicus) [0.03%]
黄箱鱼（Ostracion cubicus）基因组保守与珊瑚礁适应的进化平衡
Shui-Mu Hu,Zhi-Xiong Zhou,Jun-Yi Yang et al.
Shui-Mu Hu et al.
The yellow boxfish ( Ostracion cubicus) exhibits a combination of derived morphological traits specialized for coral reef environments and ancestral characteristics, including a fused dermal plate. Contradictory evolutionary evidence hinder...
Jie Yang,Xin Liu,Cheng-Ye Li et al.
Jie Yang et al.
Chronic pancreatitis (CP) is a progressive and irreversible fibroinflammatory disease that markedly increases susceptibility to pancreatic cancer and remains without effective targeted therapies. Among the genetic contributors to CP, the ca...
Transcriptomic profiling of cardiac development in Bama Xiang pigs across key developmental stages [0.03%]
巴马香猪心脏发育不同阶段转录组特征分析
Sheng-Nan Wang,Wen-Jie Tian,Deng-Ke Pan et al.
Sheng-Nan Wang et al.
Pigs have emerged as valuable large-animal models for cardiac xenotransplantation; however, the temporal dynamics of myocardial development in this species remains insufficiently defined. This study analyzed gene expression patterns across ...
Single-cell sequencing reveals alterations in the ovarian immune microenvironment regulated by 17β-estradiol in neonatal mice [0.03%]
单细胞测序揭示了17β-雌二醇调控的新生小鼠卵巢免疫微环境重塑
Yu-Tong Yan,Yan-Xue Li,Yi-Ting Meng et al.
Yu-Tong Yan et al.
The immunomodulatory function of estrogen within the ovary remains a subject of ongoing debate, and the neonatal ovarian immune microenvironment, particularly its modulation by estrogen, has not been comprehensively characterized. In this s...
Effects of targeted deletion of a 284 bp avian-specific highly conserved element within the Sim1 gene on flight feather development in chickens [0.03%]
家鸡Sim1基因内一个284 bp的鸟纲特异性高保守元件靶向缺失对其飞羽发育的影响研究
Keiji Kinoshita,Kumiko Tanabe,Muhammad Ameen Jamal et al.
Keiji Kinoshita et al.
Flight feathers represent a hallmark innovation of avian evolution. Recent comparative genomic analyses identified a 284 bp avian-specific highly conserved element (ASHCE) located within the eighth intron of the SIM bHLH transcription facto...
Cardiac rehabilitation in porcine models: Advances in therapeutic strategies for ischemic heart disease [0.03%]
猪模型中的心脏康复：缺血性心脏病治疗策略的进展
Shi-Qi Wang,Ting-Yu Chen,Lu Wang et al.
Shi-Qi Wang et al.
Ischemic heart disease (IHD) remains a leading contributor to cardiovascular disease (CVD) worldwide. Despite advances in diagnostic and therapeutic approaches, translational research demands robust large animal models to bridge the gap bet...
Large animal models for investigating the applications of photodynamic therapy [0.03%]
用于光动力学治疗应用研究的大动物模型
Heng-Zong Zhou,Dong-Xu Wang,Yu-Qiang Qian et al.
Heng-Zong Zhou et al.
Photodynamic therapy (PDT) is an emerging minimally invasive therapeutic modality that relies on the activation of a photosensitizing agent by light of a specific wavelength in the presence of molecular oxygen, leading to the generation of ...
Bromodomain-containing proteins in the unicellular eukaryote Tetrahymena thermophila [0.03%]
热酸性柄藻中的溴结构域含蛋白质
Zhe Zhang,Ai-Li Ju,Yuan-Yuan Wang et al.
Zhe Zhang et al.
Bromodomain (BRD)-containing proteins are central mediators of gene regulation, serving as key components of chromatin remodeling complexes and histone recognition scaffolds. By specifically recognizing acetylated lysine residues on histone...