Optimization of sgRNA expression strategy to generate multiplex gene-edited pigs [0.03%]
优化sgRNA表达策略以生成多基因编辑猪
Ju-Qing Zhang,Jian-Xiong Guo,Xiao-Jie Wu et al.
Ju-Qing Zhang et al.
Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway [0.03%]
锂慢性治疗通过PI3K-AKT信号传导通路改善氯胺酮致躁狂行为
Rong-Jun Ni,Tian-Hao Gao,Yi-Yan Wang et al.
Rong-Jun Ni et al.
Ketamine, a rapid-acting antidepressant drug, has been used to treat major depressive disorder and bipolar disorder (BD). Recent studies have shown that ketamine may increase the potential risk of treatment-induced mania in patients. Ketami...
Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses [0.03%]
健康穿山甲的病毒组揭示了与多种潜在人畜共患病毒兼容性
Feng-Juan Tian,Jing Li,Wen-Li Liu et al.
Feng-Juan Tian et al.
Previous studies have identified multiple viruses in dead or severely diseased pangolins, but descriptions of the virome in healthy pangolins are lacking. This poses a greater risk of cross-species transmission due to poor preventive awaren...
Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication [0.03%]
几种天然小分子通过干扰早期复制抑制鱼类病毒感染效果研究
Yan Zhou,Tian-Xiu Qiu,Yang Hu et al.
Yan Zhou et al.
Spring viremia of carp virus (SVCV) is globally widespread and poses a serious threat to aquatic ecology and aquaculture due to its broad host range. To develop effective agents to control SVCV infection, we selected 16 naturally active sma...
Genomic analysis of indigenous goats in Southwest Asia reveals evidence of ancient adaptive introgression related to desert climate [0.03%]
基因组分析揭示了与沙漠气候有关的古代适应性杂交痕迹
Hojjat Asadollahpour Nanaei,Yudong Cai,Akil Alshawi et al.
Hojjat Asadollahpour Nanaei et al.
Understanding how evolutionary pressures related to climate change have shaped the current genetic background of domestic animals is a fundamental pursuit of biology. Here, we generated whole-genome sequencing data from native goat populati...
Transcriptomic and metabolomic insights into the role of the flgK gene in the pathogenicity of Pseudomonas plecoglossicida to orange-spotted grouper (Epinephelus coioides) [0.03%]
flgK基因对斜带石斑鱼致病性作用的转录组和代谢组学研究
Biao Yuan,Ling-Min Zhao,Zhi-Xia Zhuang et al.
Biao Yuan et al.
Pseudomonas plecoglossicida is the pathogen responsible for visceral white spot disease in large yellow croaker (Larimichthys crocea) and orange-spotted grouper (Epinephelus coioides). Previously, RNA sequencing showed that P. plecoglossici...
Infectivity of SARS-CoV-2 and protection against reinfection in rats [0.03%]
SARS-CoV-2感染性和对再次感染的抵抗性在大鼠模型中的研究
Dandan Yu,Yanghaopeng Long,Ling Xu et al.
Dandan Yu et al.
Climate change challenge, extinction risk, and successful conservation experiences for a threatened primate species in China: Golden snub-nosed monkey (Rhinopithecus roxellana) [0.03%]
气候变化下的挑战与机遇——中国受威胁灵长类动物金丝猴的生存风险及保护成效分析
Yang Yu,Gang He,Da-Yong Li et al.
Yang Yu et al.
A wide hybrid zone mediated by precipitation contributed to confused geographical structure of Scutiger boulengeri [0.03%]
由降水介导的广泛杂交带导致了鲍氏环蛇地理结构的混乱
Xiu-Qin Lin,Yin-Meng Hou,Wei-Zhao Yang et al.
Xiu-Qin Lin et al.
Confused geographical structure of a population and mitonuclear discordance are shaped by a combination of rapid changes in population demographics and shifts in ecology. In this study, we generated a time-calibrated phylogeny of Scutiger b...