Whole-genome resequencing reveals recent signatures of selection in five populations of largemouth bass ( Micropterus salmoides) [0.03%]
全基因组重测序揭示五种大口黑鲈（Micropterus salmoides）群体中的近期选择信号
Cheng-Fei Sun,Xin-Hui Zhang,Jun-Jian Dong et al.
Cheng-Fei Sun et al.
Largemouth bass ( Micropterus salmoides) is an economically important fish species in North America, Europe, and China. Various genetic improvement programs and domestication processes have modified its genome sequence through selective pre...
Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection [0.03%]
恒河猴SARS-CoV-2感染模型中多个器官的单核转录谱分析
Qiang Ma,Wenji Ma,Tian-Zhang Song et al.
Qiang Ma et al.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and molecular understanding of SARS-CoV-2 infection-associated path...
Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish [0.03%]
斑马鱼stearoyl-CoA脱氢酶（scd）的缺乏导致脂肪肝疾病和交配行为缺陷
Shan-Shan Xu,Yi Li,Hou-Peng Wang et al.
Shan-Shan Xu et al.
Stearyl coenzyme A desaturase (SCD), also known as delta-9 desaturase, catalyzes the rate-limiting step in the formation of monounsaturated fatty acids. In mammals, depletion or inhibition of SCD activity generally leads to a decrease in tr...
Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits [0.03%]
鸡染色质可及性图谱加速鸟类表观遗传注释和生长性状基因精细定位
Xiao-Ning Zhu,Yu-Zhe Wang,Chong Li et al.
Xiao-Ning Zhu et al.
The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However, epigenetic information, such as a bird-sp...
Animal models of Alzheimer's disease: Applications, evaluation, and perspectives [0.03%]
阿尔茨海默病的动物模型：应用、评估与展望
Zhi-Ya Chen,Yan Zhang
Zhi-Ya Chen
Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease. Evidence shows that A...
Jia-Li Long,Li Lu
Jia-Li Long
EcR/USP-1-mediated ecdysteroid signaling regulates wolf spider (Pardosa pseudoannulata) development and reproduction [0.03%]
EcR/USP-1介导的蜕皮甾醇信号调控狼蛛(Pardosa pseudoannulata)的生长发育和繁殖功能
Zhi-Ming Yang,Yang-Yang Yan,Yong Wu et al.
Zhi-Ming Yang et al.
Lycosidae females demonstrate meticulous maternal care of offspring by carrying egg sacs and juvenile spiderlings during the reproductive stage. Nuclear receptors (NRs), especially the ecdysone receptor (EcR) and ultraspiracle (USP), have a...
Delineation of biomarkers and molecular pathways of residual effects of fluoxetine treatment in juvenile rhesus monkeys by proteomic profiling [0.03%]
基于蛋白质组学的氟西汀治疗未成年猕猴的残留效应的生物标志物和分子途径的研究
Yu Yan,Dong Ik Park,Anja Horn et al.
Yu Yan et al.
Fluoxetine (Prozac™) is the only antidepressant approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in children. Despite its considerable efficacy as a selective serotonin reuptake inh...
Unveiling the functional and evolutionary landscape of RNA editing in chicken using genomics and transcriptomics [0.03%]
利用基因组学和转录组学揭示鸡的RNA编辑的功能和进化景观
Yun-Mei Wang,Ling-Qun Ye,Ming-Shan Wang et al.
Yun-Mei Wang et al.
The evolutionary and functional features of RNA editing are well studied in mammals, cephalopods, and insects, but not in birds. Here, we integrated transcriptomic and whole-genomic analyses to exhaustively characterize the expansive repert...
A glimpse into the biodiversity of insects in Yunnan: An updated and annotated checklist of butterflies (Lepidoptera, Papilionoidea) [0.03%]
云南昆虫多样性研究进展：膜翅类蝶类（Papilionoidea）的更新和标注清单
Tian-Tian Yu,Zhou Chang,Zhi-Wei Dong et al.
Tian-Tian Yu et al.