Genomic insights into the convergent evolution of desert adaptation in camels and antelopes [0.03%]
骆驼和羚羊独立适应沙漠环境的基因组学洞察
Jiong Zhou,Xiao-Fang Zhou,Hui-Shan Yue et al.
Jiong Zhou et al.
Extreme heat and chronic water scarcity present formidable challenges to large desert-dwelling mammals. In addition to camels, antelopes within the Hippotraginae and Alcelaphinae subfamilies also exhibit remarkable physiological and genetic...
Discovery of an ancient Himalayan birch mouse lineage illuminates the evolution of the family Sicistidae (Rodentia: Dipodoidea), with descriptions of a new genus and two new species [0.03%]
一种古代喜马拉雅桦鼠谱系的发现阐明了Sicistidae鼠类家族（啮齿目：跳鼠总科）的进化，并描述了一个新属和两个新物种
Zhong-Xu Zhu,Quan Li,Wen-Yu Song et al.
Zhong-Xu Zhu et al.
Birch mice (family Sicistidae) are small dipodoid rodents distributed in regions surrounding the Qinghai-Xizang Plateau and extending across the Palearctic. In China, members of the genus Sicista are rarely recorded, and their systematics r...
Evolutionary history of Old World cellar spiders in the context of Neo-Tethyan sea-land transformations [0.03%]
新特提斯海陆演变背景下的古北区地穴蜘蛛辐射演化历史研究
Zhi-Yuan Yao,Shu-Qiang Li
Zhi-Yuan Yao
The ancient Neo-Tethyan region underwent profound tectonic transformations, including the orogenesis of the Xizang Plateau and the westward retreat and ultimate closure of the Neo-Tethyan Ocean. These events significantly influenced the div...
Distributions of parvalbumin, calbindin-D28k, and calretinin in the cerebrum of Chinese tree shrews ( Tupaia belangeri chinensis): A high-resolution neuroanatomical resource [0.03%]
Chinese树鼩大脑中parvalbumin，calbindin-d28k和calretinin的分布：一个高分辨率神经解剖资源
Rong Zhang,Jia-Li Long,Yi-Fan Ye et al.
Rong Zhang et al.
The Chinese tree shrew has gained prominence as a model organism due to its phylogenetic proximity to primates, offering distinct advantages over traditional rodent models in biomedical research. However, the neuroanatomy of this species re...
Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain [0.03%]
树鼩脑中GFAP反应性星形胶质细胞的解剖学分布图
Ya-Tao Wang,Qi-Qi Xu,Shuo-Wen Wang et al.
Ya-Tao Wang et al.
Astrocytes are associated with varying brain size between rodents and primates. As a close evolutionary relative of primates, the tree shrew ( Tupaia belangeri) provides a valuable comparative model for investigating glial architecture. How...
Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice [0.03%]
通过凝胶状明胶甲基丙烯酰胺（GelMA）水凝胶缓释系统皮下递送淫羊藿次苷I改善生殖衰老小鼠卵巢功能
Jia-Lian Mao,Xiang-Yi Wu,Ling-Xi Li et al.
Jia-Lian Mao et al.
Ovarian aging is characterized by a progressive decline in oocyte quality and quantity with age. Icariin (ICA), a flavonoid compound derived from Epimedium species, has demonstrated potential as an agent for ovarian restoration. In this stu...
YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2 [0.03%]
YAP1通过调控LATS2介导的Hippo信号通路负反馈机制促进脂肪细胞分化
Mei Zhou,Yue-Qi Zhao,Wei Yan et al.
Mei Zhou et al.
Adipose-derived mesenchymal stem cells (ADSCs) represent a readily accessible and important source of mesenchymal stem cells (MSCs) capable of multilineage differentiation. The Hippo signaling pathway effector YAP has emerged as a pivotal r...
Lycium barbaru m glycopeptide ameliorates aberrant neuronal activity via ER stress modulation in ventral forebrain organoids derived from depressive patients [0.03%]
救阴茶多糖通过调节抑郁患者衍生的前脑类器官中 ventral 部分的内质网压力来改善异常神经元活性
Meng-Dan Tao,Can Wang,Xin-Hao Wu et al.
Meng-Dan Tao et al.
Major depressive disorder (MDD) is a debilitating psychiatric condition associated with substantial personal, societal, and economic costs. Despite considerable advances in research, most conventional antidepressant therapies fail to achiev...
Phenotypic, transcriptomic, and genomic analyses reveal the spatiotemporal patterns and associated genes of coarse hair density in goats [0.03%]
表型、转录组和基因组分析揭示了粗毛密度在山羊中的时空模式及关联基因
Ji-Pan Zhang,Min Xiao,Jia-Bei Fang et al.
Ji-Pan Zhang et al.
The genetic regulation of hair density in animals remains poorly understood. The Dazu black goat, characterized by its black coarse hair and white skin, provides a unique model for dissecting coarse hair density (CHD). Using high-resolution...
Single-cell RNA-seq provides insight into the underdeveloped immune system of germ-free mice [0.03%]
单细胞RNA测序揭示无菌小鼠发育不良的免疫系统
Yi-Fei Sheng,Wei Cheng,Yin Zhang et al.
Yi-Fei Sheng et al.
Germ-free mice exhibit profound immunological immaturity. Despite recent studies emphasizing the role of specific bacterium-derived metabolites in immune cell development and differentiation, the mechanisms linking microbiota absence to sys...