Insights into the genetic architecture of congenital heart disease from animal modeling [0.03%]
动物建模对先天性心脏病遗传构成的洞见
Wenjuan Zhu,Cecilia W Lo
Wenjuan Zhu
Congenital heart disease (CHD) is observed in up to 1% of live births and is one of the leading causes of mortality from birth defects. While hundreds of genes have been implicated in the genetic etiology of CHD, their role in CHD pathogene...
Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain [0.03%]
PLX3397耗竭小胶质细胞通过调节脑内与炎症相关的基因表达减轻MK-801所致的小鼠异常运动行为
Rong-Jun Ni,Yi-Yan Wang,Tian-Hao Gao et al.
Rong-Jun Ni et al.
Acute administration of MK-801 (dizocilpine), an N-methyl-D-aspartate receptor (NMDAR) antagonist, can establish animal models of psychiatric disorders. However, the roles of microglia and inflammation-related genes in these animal models o...
Loss of behavioral stress response in blind cavefish reduces energy expenditure [0.03%]
盲穴居鱼丧失行为应激反应可减少能量消耗
Jiang-Hui Zhang,Rui Long,Yang-Yang Jing et al.
Jiang-Hui Zhang et al.
The stress response is essential for animal self-defense and survival. However, species may exhibit stress response variation depending on their specific environmental and selection pressures. Blind cavefish dwell in cave environments, whic...
Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models [0.03%]
病毒感染性脑炎的研究进展：病毒传播、宿主免疫和实验动物模型研究
Dan Yang,Xiao-Jing Li,De-Zhen Tu et al.
Dan Yang et al.
Viral infections have led to many public health crises and pandemics in the last few centuries. Neurotropic virus infection-induced viral encephalitis (VE), especially the symptomatic inflammation of the meninges and brain parenchyma, has a...
EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1, TRF2, and RAD50 [0.03%]
EPAS1通过增强TRF1、TRF2和RAD50的转录来防止端粒损伤诱导的衰老
Kai-Qin Li,Gao-Jing Liu,Xiu-Yun Liu et al.
Kai-Qin Li et al.
Telomeres are nucleoprotein structures located at the end of each chromosome, which function in terminal protection and genomic stability. Telomeric damage is closely related to replicative senescence in vitro and physical aging in vivo. As...
Jump further, leap higher, and consolidate stronger: A brief review of the long-term partnership between Kunming Institute of Zoology (KIZ) and the Chinese University of Hong Kong (CUHK) in bioresources and molecular research [0.03%]
更进一步，跃上高峰，厚积薄发——中国科学院昆明动物研究所与中国香港中文大学长期合作回顾与展望：生物资源及分子生物学研究
Nelson Tang,Yong-Tang Zheng,Hui Zhao et al.
Nelson Tang et al.
Ming-Juan Li,Xiao-Hong Xu
Ming-Juan Li
Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility [0.03%]
转录因子Dmrt1通过触发SPRY1-NF-κB通路维持睾丸免疫稳态和雄性生育力
Meng-Fei Zhang,Shi-Cheng Wan,Wen-Bo Chen et al.
Meng-Fei Zhang et al.
Bacterial or viral infections, such as Brucella, mumps virus, herpes simplex virus, and Zika virus, destroy immune homeostasis of the testes, leading to spermatogenesis disorder and infertility. Of note, recent research shows that SARS-CoV-...
Reconstructing early transmission networks of SARS-CoV-2 using a genomic mutation model [0.03%]
基于基因组突变模型的早期SARS-CoV-2传播网络重建
Chao-Yuan Cheng,Zhi-Bin Zhang
Chao-Yuan Cheng
The coronavirus disease 2019 (COVID-19) pandemic has greatly damaged human society, but the origins and early transmission patterns of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen remain unclear. Here, we recons...
Defining honeybee subspecies in an evolutionary context warrants strategized conservation [0.03%]
从进化角度定义意蜂亚种有利于制定策略进行保护
Lifei Qiu,Jiangxing Dong,Xingan Li et al.
Lifei Qiu et al.
Despite the urgent need for conservation consideration, strategic action plans for the preservation of the Asian honeybee, Apis cerana Fabricius, 1793, remain lacking. Both the convergent and divergent adaptations of this widespread insect ...