Choline dehydrogenase interacts with SQSTM1 to activate mitophagy and promote coelomocyte survival in Apostichopus japonicus following Vibrio splendidus infection [0.03%]
Vibrio splendidus感染下刺参Apostichopus japonicus中胆碱脱氢酶通过与SQSTM1互作激活线粒体自噬促进变形细胞存活
Lian-Lian Sun,Ying-Fen Dai,Mei-Xiang You et al.
Lian-Lian Sun et al.
Previous studies have shown that Vibrio splendidus infection causes mitochondrial damage in Apostichopus japonicus coelomocytes, leading to the production of excessive reactive oxygen species (ROS) and irreversible apoptotic cell death. Eme...
Dihydroartemisinin inhibits plasmid transfer in drug-resistant Escherichia coli via limiting energy supply [0.03%]
二氢青蒿素通过限制能量供应抑制耐药大肠杆菌的质粒转移
Xue-Yang Wang,Huang-Wei Song,Tian Yi et al.
Xue-Yang Wang et al.
Conjugative transfer of antibiotic resistance genes (ARGs) by plasmids is an important route for ARG dissemination. An increasing number of antibiotic and nonantibiotic compounds have been reported to aid the spread of ARGs, highlighting po...
Probing the processing of facial expressions in monkeys via time perception and eye tracking [0.03%]
利用时间感知和眼动追踪探究猴子对面部表情的处理过程
Xin-He Liu,Lu Gan,Zhi-Ting Zhang et al.
Xin-He Liu et al.
Accurately recognizing facial expressions is essential for effective social interactions. Non-human primates (NHPs) are widely used in the study of the neural mechanisms underpinning facial expression processing, yet it remains unclear how ...
Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease [0.03%]
基于长时程增益的筛选识别出神经元PYGM作为参与阿尔茨海默病的突触可塑性调节因子
Ting Wang,Yun-Qiang Zhou,Yong Wang et al.
Ting Wang et al.
Synaptic dysfunction is an important pathological hallmark and cause of Alzheimer's disease (AD). High-frequency stimulation (HFS)-induced long-term potentiation (LTP) has been widely used to study synaptic plasticity, with impaired LTP fou...
Identifying priority protection areas of key food resources of the giant panda [0.03%]
圈养大熊猫重要食物资源优先保护区域识别研究
Ying-Jie Ma,Meng Wang,Xiao-Yu Hu et al.
Ying-Jie Ma et al.
Animals that live in seasonal environments adjust their reproduction cycle to optimize seasonal forage quality. Giant pandas ( Ailuropoda melanoleuca) are seasonal altitudinal migrants that feed on bamboo shoots and leaves with different nu...
ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions [0.03%]
热应激下ATF6通过调节器官稳态加重早期猪胚胎发育中细胞凋亡的作用机制研究
Ming-Hong Sun,Wen-Jie Jiang,Xiao-Han Li et al.
Ming-Hong Sun et al.
Activating transcription factor 6 (ATF6), one of the three sensor proteins in the endoplasmic reticulum (ER), is an important regulator of ER stress-induced apoptosis. ATF6 resides in the ER and, upon activation, is translocated to the Golg...
Population genetics of marmosets in Asian primate research centers and loci associated with epileptic risk revealed by whole-genome sequencing [0.03%]
亚洲灵长类研究中心狨猴群体遗传学及全基因组测序发现的与癫痫风险相关的位点
XiangYu Yang,YaFei Mao,Xuan-Kai Wang et al.
XiangYu Yang et al.
The common marmoset ( Callithrix jacchus) has emerged as a valuable nonhuman primate model in biomedical research with the recent release of high-quality reference genome assemblies. Epileptic marmosets have been independently reported in t...
William R Jeffery,Li Ma,Ya-Hui Zhao
William R Jeffery
The first cavefish in the Dinaric Karst? Cave colonization made possible by phenotypic plasticity in Telestes karsticus [0.03%]
关于迪纳里克石灰岩洞穴鱼的问题？Telestes karsticus通过表型可塑性实现洞穴定居
Mateo Čupić,Zoran Marčić,Marko Lukić et al.
Mateo Čupić et al.
Cave animals are an excellent model system for studying adaptive evolution. At present, however, little is known about the mechanisms that enable surface colonizers to survive in the challenging environment of caves. One possibility is that...
Developmental environment contributes to rapid trait shifts among newly colonized subterranean habitats [0.03%]
发育环境对快速进入新殖民地的地下亚生境的特征转变有贡献
Nathan E Swanson,Andrew G Gluesenkamp,Alexandra E Donny et al.
Nathan E Swanson et al.
Recent colonization of extreme environments provides unique opportunities to study the early steps of adaptation and the potential for rapid convergent evolution. However, phenotypic shifts during recent colonization may also be due to plas...