Genetically modified pigs: Emerging animal models for hereditary hearing loss [0.03%]
转基因猪：遗传性听力损失的动物模型新进展
Xiao Wang,Tian-Xia Liu,Ying Zhang et al.
Xiao Wang et al.
Hereditary hearing loss (HHL), a genetic disorder that impairs auditory function, significantly affects quality of life and incurs substantial economic losses for society. To investigate the underlying causes of HHL and evaluate therapeutic...
Bofeng Han,Weien Liang,Xiao-Jiang Li et al.
Bofeng Han et al.
Huntington's disease (HD) is a hereditary neurodegenerative disorder for which there is currently no effective treatment available. Consequently, the development of appropriate disease models is critical to thoroughly investigate disease pr...
Genetically modified non-human primate models for research on neurodegenerative diseases [0.03%]
用于神经退行性疾病研究的转基因非人灵长类动物模型
Ming-Tian Pan,Han Zhang,Xiao-Jiang Li et al.
Ming-Tian Pan et al.
Neurodegenerative diseases (NDs) are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral...
Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases [0.03%]
基因编辑兔：作为充满前景的实验动物模型在各种疾病研究中的潜力释放
Yang Han,Jiale Zhou,Renquan Zhang et al.
Yang Han et al.
Animal models are extensively used in all aspects of biomedical research, with substantial contributions to our understanding of diseases, the development of pharmaceuticals, and the exploration of gene functions. The field of genome modifi...
Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation [0.03%]
比较灵长类和猪的细胞揭示PINK1在灵长类中特有的表达和磷酸化形式
Xiu-Sheng Chen,Rui Han,Yan-Ting Liu et al.
Xiu-Sheng Chen et al.
PTEN-induced putative kinase 1 (PINK1), a mitochondrial kinase that phosphorylates Parkin and other proteins, plays a crucial role in mitophagy and protection against neurodegeneration. Mutations in PINK1 and Parkin can lead to loss of func...
Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids [0.03%]
SHROOM3的丢失通过调节恒河猴类器官中的细胞骨架蛋白影响神经上皮细胞的形态
Peng Li,Ting Zhang,Ruo Wu et al.
Peng Li et al.
Neural tube defects (NTDs) are severe congenital neurodevelopmental disorders arising from incomplete neural tube closure. Although folate supplementation has been shown to mitigate the incidence of NTDs, some cases, often attributable to g...
Ancient DNA unravels species identification from Laosicheng site, Hunan Province, China, and provides insights into maternal genetic history of East Asian leopards [0.03%]
古DNA破解中国湖南省劳氏城遗址物种鉴定并揭示东亚豹的母系遗传史
Ming Zhang,Cai-Hui Wang,Yu-Xin Zheng et al.
Ming Zhang et al.
Molecular phylogenetic relationships based on mitochondrial genomes of novel deep-sea corals (Octocorallia: Alcyonacea): Insights into slow evolution and adaptation to extreme deep-sea environments [0.03%]
基于新型深海珊瑚线粒体基因组的分子系统关系(八放珊瑚亚纲：软珊瑚目)：对极端深海环境的缓慢进化和适应性的启示
Zhan-Fei Wei,Kai-Wen Ta,Nan-Nan Zhang et al.
Zhan-Fei Wei et al.
A total of 10 specimens of Alcyonacea corals were collected at depths ranging from 905 m to 1 633 m by the manned submersible Shenhai Yongshi during two cruises in the South China Sea (SCS). Based on mitochondrial genomic characteristics, m...
Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders [0.03%]
印度的季风影响了Scytodes喷蛛Thoracica组的扩散过程
Yu-Fa Luo,Shu-Qiang Li
Yu-Fa Luo
We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level (61 species in the thoracica group and 84 species of Scytodes) using DNA data from six loci. Our resu...
Combined ATAC-seq, RNA-seq, and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster ( Crassostrea ariakensis) [0.03%]
结合ATAC序列、RNA序列和GWAS分析揭示了金江牡蛎（Crassostrea ariakensis）的糖原代谢调控网络
Biao Wu,Xi Chen,Jie Hu et al.
Biao Wu et al.
Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of oysters. The Jinjiang oyster ( Crassostrea ariakensis) is an economically and ecological...