Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis [0.03%]
多发性硬化动物模型海马神经元结构可塑性的变化
Poornima D E Weerasinghe-Mudiyanselage,Sohi Kang,Joong-Sun Kim et al.
Poornima D E Weerasinghe-Mudiyanselage et al.
Structural plasticity is critical for the functional diversity of neurons in the brain. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for multiple sclerosis (MS), successfully mimicking its key pathological...
Identification and effective regulation of scarb1 gene involved in pigmentation change in autotetraploid Carassius auratus [0.03%]
四倍体鲫鱼scarb1基因的鉴定及其在色素变化中的有效调控作用研究
Xi-Dan Xu,Yue Zhou,Chong-Qing Wang et al.
Xi-Dan Xu et al.
The autotetraploid Carassius auratus (4nRR, 4 n=200, RRRR) is derived from whole-genome duplication of Carassius auratus red var. (RCC, 2 n=100, RR). In the current study, we demonstrated that chromatophores and pigment changes directly cau...
Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice [0.03%]
尸胺通过Rac1发挥治疗骨质疏松的潜在作用：来自斑马鱼和小鼠的研究结果
Rui-Xue Jiang,Nan Hu,Yu-Wei Deng et al.
Rui-Xue Jiang et al.
Osteoporosis is a prevalent metabolic bone disease. While drug therapy is essential to prevent bone loss in osteoporotic patients, current treatments are limited by side effects and high costs, necessitating the development of more effectiv...
Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish [0.03%]
雄性激素信号通过抑制脂质从头合成来缓解斑马鱼的脂质沉积问题
Jing-Yi Jia,Guang-Hui Chen,Ting-Ting Shu et al.
Jing-Yi Jia et al.
Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in t...
Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states [0.03%]
不同蛰伏状态下脊椎动物生理变化及潜在关系的比较转录组证据
Yu-Han Niu,Li-Hong Guan,Cheng Wang et al.
Yu-Han Niu et al.
Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving environments. After a period of dormancy, organisms often exhibit exceptional resilience. This period is typically divided into hibernation and aest...
Deciphering the population structure and genetic basis of growth traits from whole-genome resequencing of the leopard coral grouper ( Plectropomus leopardus) [0.03%]
豹纹鲈的群体结构和生长性状的遗传基础的全基因组解析
Shao-Xuan Wu,Qi-Fan Zeng,Wen-Tao Han et al.
Shao-Xuan Wu et al.
The leopard coral grouper ( Plectropomus leopardus) is a species of significant economic importance. Although artificial cultivation of P. leopardus has thrived in recent decades, the advancement of selective breeding has been hindered by t...
Genetic mechanism of body size variation in groupers: Insights from phylotranscriptomics [0.03%]
石斑鱼体型变异的遗传机制：来自系统转录组学的见解
Wei-Wei Zhang,Zhuo-Ying Weng,Xi Wang et al.
Wei-Wei Zhang et al.
Animal body size variation is of particular interest in evolutionary biology, but the genetic basis remains largely unknown. Previous studies have shown the presence of two parallel evolutionary genetic clusters within the fish genus Epinep...
Xiao-Jiang Li,Liangxue Lai
Xiao-Jiang Li
Comparative transcriptome analysis between rhesus macaques ( Macaca mulatta) and crab-eating macaques ( M. fascicularis) [0.03%]
恒河猴(Macaca mulatta)和长尾猕猴(M. fascicularis)之间的比较转录组分析
Yu-Xiang Mao,Yamei Li,Zikun Yang et al.
Yu-Xiang Mao et al.
Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques ( Macaca mulatta, MMU) and crab-eating macaques ( M. fascicularis, MFA) serve as crucial nonhuman ...
Generation of mitochondrial replacement monkeys by female pronucleus transfer [0.03%]
通过女性原核移植生成线粒体替换猴
Chun-Yang Li,Xing-Chen Liu,Yu-Zhuo Li et al.
Chun-Yang Li et al.
Mutations in mitochondrial DNA (mtDNA) are maternally inherited and have the potential to cause severe disorders. Mitochondrial replacement therapies, including spindle, polar body, and pronuclear transfers, are promising strategies for pre...