Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury [0.03%]
探索轻度创伤性脑损伤诱导的创伤后头痛小鼠模型中的脑结构和功能异常
Dan Yang,Bin-Bin Nie,Jin-Gang He et al.
Dan Yang et al.
Mild traumatic brain injury (mTBI)-induced post-traumatic headache (PTH) is a pressing public health concern and leading cause of disability worldwide. Although PTH is often accompanied by neurological disorders, the exact underlying mechan...
Functional dissection of parabrachial substrates in processing nociceptive information [0.03%]
参与疼痛信息处理的傍皮层底核不同亚区的功能解剖关系研究
Jin Ke,Wei-Cheng Lu,Hai-Yang Jing et al.
Jin Ke et al.
Painful stimuli elicit first-line reflexive defensive reactions and, in many cases, also evoke second-line recuperative behaviors, the latter of which reflects the sensing of tissue damage and the alleviation of suffering. The lateral parab...
Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis [0.03%]
多组学分析揭示出云南树鼩肾上腺具有类似人类的特征
Jing-Hang Jiang,Yi-Fu Wang,Jie Zheng et al.
Jing-Hang Jiang et al.
The Chinese tree shrew ( Tupaia belangeri chinensis) has emerged as a promising model for investigating adrenal steroid synthesis, but it is unclear whether the same cells produce steroid hormones and whether their production is regulated i...
Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATAC-seq and scRNA-seq [0.03%]
通过单细胞染色质及转录组测序揭示哺乳动物配子发生过程中细胞间通讯介导的转录重编程
Hai-Quan Wang,Xiao-Long Wu,Jing Zhang et al.
Hai-Quan Wang et al.
Meiosis is a highly complex process significantly influenced by transcriptional regulation. However, studies on the mechanisms that govern transcriptomic changes during meiosis, especially in prophase I, are limited. Here, we performed sing...
Spatially resolved transcriptomic profiling of placental development in dairy cow [0.03%]
奶牛胎盘发育的空间转录组学分析
Guang-Hui Tan,Shi-Jie Liu,Ming-Le Dou et al.
Guang-Hui Tan et al.
The placenta plays a crucial role in successful mammalian reproduction. Ruminant animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledo...
Applications of single-cell RNA sequencing in spermatogenesis and molecular evolution [0.03%]
单细胞RNA测序在精子发生及分子进化研究中的应用
Wen-Bo Chen,Meng-Fei Zhang,Fan Yang et al.
Wen-Bo Chen et al.
Spermatogenic cell heterogeneity is determined by the complex process of spermatogenesis differentiation. However, effectively revealing the regulatory mechanisms underlying mammalian spermatogenic cell development and differentiation via t...
Improvement in Tol2 transposon for efficient large-cargo capacity transgene applications in cultured cells and zebrafish ( Danio rerio) [0.03%]
提高Tol2转座子的大载货量转基因在体外培养细胞和斑马鱼（Danio rerio）中的高效应用能力
Peng-Cheng Wang,Hao Deng,Rang Xu et al.
Peng-Cheng Wang et al.
Most viruses and transposons serve as effective carriers for the introduction of foreign DNA up to 11 kb into vertebrate genomes. However, their activity markedly diminishes with payloads exceeding 11 kb. Expanding the payload capacity of t...
Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice [0.03%]
小鼠中野生型HRAS过表达驱动非酒精性脂肪肝向肝细胞癌进展
Chen Ling,Su-Su Liu,Yu-Ya Wang et al.
Chen Ling et al.
Hepatocellular carcinoma (HCC), a prevalent solid carcinoma of significant concern, is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic outcomes. The etiology and pathological progression of ...
PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior [0.03%]
PCDH17通过调节ROCK2依赖的肌动蛋白细胞骨架控制来限制树突棘形态发生，从而调节情绪行为
Laidong Yu,Fangfang Zeng,Mengshu Fan et al.
Laidong Yu et al.
Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain function. Synaptic abnormalities, such as defects in the density and morphology of postsynaptic dendritic spi...
Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid [0.03%]
整合多组学分析揭示鱼类虹彩病毒介导的肝代谢重编程及α-亚麻酸抗病毒作用
Lin Liu,Ya Zhang,Meng-Di Yuan et al.
Lin Liu et al.
Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate; however, the molecular mechanisms underpinning its pathogenesis are not well elucidated. Here, a multi-omics approach was applied to groupers infect...