Kun Wu,Danqi Qin,Yang Qian et al.
Kun Wu et al.
The mutation rate is a pivotal biological characteristic, intricately governed by natural selection and historically garnering considerable attention. Recent advances in high-throughput sequencing and analytical methodologies have profoundl...
Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models [0.03%]
动物模型的COVID-19免疫学：机制和治疗研究进展
Hong-Yi Zheng,Tian-Zhang Song,Yong-Tang Zheng
Hong-Yi Zheng
The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019 (COVID-19) immunobiology, often resulting in a lack of reproducibility when extrapolated to the whole organism. Consequen...
Qiao Guan,Yuan Zhang,Zhi-Kun Wang et al.
Qiao Guan et al.
Aging is an inevitable physiological process, often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health risks. Research on skeletal diseases caused by aging in humans is challenging due to leng...
Mitogenomic phylogeny, biogeography, and cryptic divergence of the genus Silurus (Siluriformes: Siluridae) [0.03%]
基于线粒体基因组的青鱼属（鲤形目胡颖科）系统发育、生物地理及遗传分化研究
Weitao Chen,Nicolas Hubert,Yuefei Li et al.
Weitao Chen et al.
The genus Silurus, an important group of catfish, exhibits heterogeneous distribution in Eurasian freshwater systems. This group includes economically important and endangered species, thereby attracting considerable scientific interest. De...
Ji Hu,Ping Zheng
Ji Hu
Kaixuan Wang,Hongshuang Wang,Xiaohui Wang
Kaixuan Wang
Microglia in drug addiction: A perspective from neuroimmunopharmacology [0.03%]
神经免疫药理学视角下的药物成瘾与小胶质细胞
Cong Lin,Xiaohui Wang
Cong Lin
General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain [0.03%]
吸入麻醉药通过发育期大脑少突胶质细胞诱导神经毒性
Wen-Xin Hang,Yan-Chang Yang,Yu-Han Hu et al.
Wen-Xin Hang et al.
General anesthetic agents can impact brain function through interactions with neurons and their effects on glial cells. Oligodendrocytes perform essential roles in the central nervous system, including myelin sheath formation, axonal metabo...
In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia [0.03%]
活体成像发现，在异丙酚和七氟醚麻醉期间存在神经递质动力学的同步相关性
Gao-Lin Qiu,Li-Jun Peng,Peng Wang et al.
Gao-Lin Qiu et al.
General anesthesia is widely applied in clinical practice. However, the precise mechanism of loss of consciousness induced by general anesthetics remains unknown. Here, we measured the dynamics of five neurotransmitters, including γ-aminob...
Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice [0.03%]
整合核糖体和蛋白质组分析通过抑制新生小鼠ADNP揭示异氟烷诱导的长期社会行为和认知障碍的新见解
Li-Rong Liang,Bing Liu,Shu-Hui Cao et al.
Li-Rong Liang et al.
A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment. Davunetide, an active fragment of the activity-dependent neuroprotec...